Methods useful in optimizing the treatment of neuropathies and targeting tissues with cosmetic botulinum injections
The present invention pertains to methods of determining where, on the skin, a diagnostic, therapeutic, or cosmetic agent is likely to be most effectively applied (e.g., injected), and to methods for monitoring a patient after such an agent has been administered. The monitoring can produce information useful in determining whether a diagnostic, therapeutic (e.g., surgical), or cosmetic regime should be initiated, continued, continued in a modified fashion, or terminated (e.g., for a brief or prolonged period of time). The methods can be repeated periodically and use a non-invasive, in vivo form of digital image speckle correlation (DISC) to track deformation of the skin.
1. A method for identifying one or more injection sites for a cosmetic agent that induces muscle paralysis, the method comprising:
(a) taking one or more photographs of a patient's skin in an area or areas to be treated with the cosmetic agent while the patient is at rest;
(b) taking one or more photographs of the patient's skin in the area or areas to be treated with the cosmetic agent while the patient is performing an action;
(c) performing digital image speckle correlation (DISC) analysis on the photographs from steps (a) and (b), thereby generating a vector diagram comprising a series of displacement vectors that each represents the movement of a pore from its at rest position to its final location;
(d) identifying one or more locus of large stress in the vector diagram; and
(e) identifying the location for the one or more injection sites for the cosmetic agent within the one or more locus of large stress.
2. The method of claim 1 , further comprising the step of injecting the cosmetic agent at the locus of large stress.
3. The method of claim 2 , wherein the steps (a) to (e) are subsequently repeated to monitor at least one effect on the skin after injection with the cosmetic agent.
4. The method of claim 3 , wherein the steps (a) to (e) are repeated within 24 weeks after injection with the cosmetic agent.
5. The method of claim 1 , wherein the one or more areas to be treated comprise skin of the face or neck.
6. The method of claim 1 , wherein the action performed by the patient comprises smiling; moving the jaw, lips or tongue; moving the eyes; or moving the forehead.
7. The method of claim 1 , wherein the one or more areas to be treated comprise skin having forehead lines, glabellar lines, or crow's feet.
8. A method for administering to a patient a cosmetic agent that induces muscle paralysis, the method comprising:
(a) identifying one or more injection sites for the cosmetic agent comprising the steps of:
(i) taking one or more photographs of the patient's skin in the area or areas to be treated with the cosmetic agent while the patient is at rest;
(ii) taking one or more photographs of the patient's skin in the area or areas to be treated with the cosmetic agent while the patient is performing an action;
(iii) performing digital image speckle correlation (DISC) analysis on the photographs from steps (a) and (b), thereby generating a vector diagram comprising a series of displacement vectors that each represents the movement of a pore from its at rest position to its final location;
(iv) identifying one or more locus of large stress in the vector diagram; and
(b) injecting the cosmetic agent into the one or more locus of large stress.
9. The method of claim 8 , wherein the one or more areas to be treated comprise skin of the face or neck.
10. The method of claim 8 , wherein the action performed by the patient comprises smiling; moving the jaw, lips or tongue; moving the eyes; or moving the forehead.
11. The method of claim 8 , wherein the one or more areas to be treated comprise skin having forehead lines, glabellar lines, or crow's feet.
12. The method of claim 8 , wherein the steps (a) to (e) are subsequently repeated to monitor at least one effect on the skin after injection with the cosmetic agent.
13. The method of claim 12 , wherein the steps (a) to (e) are repeated within 24 weeks after injection with the cosmetic agent.