Herbo-mineral formulation for the treatment of cancer and method of preparation thereof
Herbo-mineral formulation for the treatment of cancer and method of preparation are disclosed herein. The disclosed formulation includes a combination of herb and mineral components that facilitate in controlling abnormal cell proliferation. The formulation can thus be used in treatment of cancer and related mobidities.
1. An oral formulation, comprising:
Withania somnifera in an amount in the range of 6 to 10 wt. %;
Sida cordifolia in an amount in the range of 6 to 10 wt. %;
Asparagus racemosus in an amount in the range of 4 to 8 wt. %;
Tinospora cordifolia in an amount in the range of 4 to 8 wt. %;
Moringa oleifera in an amount in the range of 4 to 8 wt. %;
Picrorhiza kurroa in an amount in the range of 4 to 8 wt. %;
Ocimum sanctum in an amount in the range of 4 to 8 wt. %;
Curcuma longa in an amount in the range of 5 to 9 wt. %;
Piper longum in an amount in the range of 2 to 6 wt. %;
Piper nigrum in an amount in the range of 2 to 6 wt. %;
Zingiber officinalis in an amount in the range of 2 to 6 wt. %;
Terminalia chebula in an amount in the range of 2 to 6 wt. %;
Terminalia bellerica in an amount in the range of 2 to 6 wt. %;
Emblica officinalis in an amount in the range of 2 to 6 wt. %;
Shilajit in an amount in the range of 4 to 8 wt %;
Abhraka Bhasma in an amount in the range of 2 to 4 wt. %;
Trivanga Bhasma in an amount in the range of 0 to 2 wt %;
Pravala Bhasma in an amount in the range of 0 to 2 wt. %;
Loha Bhasma in an amount in the range of 2 to 4 wt. %; and
Swarna Makshika Bhasma in an amount in the range of 0 to 2 wt. %, of the total formulation.
2. The formulation as claimed in claim 1 , further comprising a suitable amount of gum acacia.
3. The formulation as claimed in claim 1 , further comprising at least one additive selected from the group consisting of a flavor, a colorant, a preservative, and a pH adjuster.
4. The formulation as claimed in claim 1 , wherein said formulation is in a form selected from the group consisting of powder, emulsion, tablets, capsules, troches and pills.
5. The formulation as claimed in claim 1 , wherein said formulation is in the form of a tablet.
6. The formulation as claimed in claim 5 , wherein said tablet is in the form of a 500 mg tablet.
7. A process for the preparation of formulation claimed in claim 1 , comprising:
levigating bhasmas and shilajit;
adding finely powdered herbs; and
adding grinding decoction while continuing grinding to obtain a ground mass.
8. The process for the preparation of a formulation as claimed in claim 7 , wherein said finely powdered herbs comprises of finely powdered form of;
Withania somnifera (Dried root), Sida cordifolia (Dried root), Terminalia chebula (Dry fruits), Terminalia bellerica (Dried fruits), Emblica officinalis (Dried fruits), Asparagus racemosus (Dried root), Tinospora cordifolia (Dried stem), Piper longum (Dried fruit), Piper nigrum (Dried fruit), Zingiber officinalis (Dried rhizome), Moringa oleifera (Dried stem bark), Picrorhiza kurroa (Dried root), Ocimum sanctum (Dried leaves) and Curcuma longa (Dried rhizome).
9. The process for the preparation of a formulation as claimed in claim 7 , wherein said grinding decoction is a decoction of at least one herb selected from the group consisting of Aegle marmelos, Premna mucronata, Oroxylum indicum, Steriospermum suaveolens, Gmelina arborea, Solanum indicum, Solanum xanthocarpum, Tribulus terrestris, Uraria picta, Desmodium gangeticum, Vica rosea, Semecarpus anacardium, Asparagus racemosus, Momordica charantia, Acacia catechu, Ocimum sanctum, Rubia cordifolia, Bauhinia variegate, Adhatoda vasica, Eclipta alba, Moringa oleifera, Cynodon dactylon, Tinospora cordifolia, Crotolaria juncea, Cuminum cyminum, Smilax china, Mimosa pudica, Calotropis procera, Sida rombifolia, Murraya koeinigi and Trichosanthus dioica.
10. A method of inducing a cytotoxic, apoptotic, antiproliferative, and/or growth inhibitory effect in cancer cells comprising:
treating said cancer cells with a formulation claimed in claim 1 .
11. A method of treating cancer comprising administering a therapeutically effective amount of the formulation claimed in claim 1 .
12. The method of treating cancer as claimed in claim 11 , wherein said effective amount of the formulation is 1000 mg tablets thrice a day.
13. The method as claimed in claim 11 , wherein said formulation is administered along with administration of at least one other cancer medication.
14. The method as claimed in claim 13 wherein said at least one other cancer medication is selected from chemotherapy and radiotherapy.
15. The formulation as claimed in claim 2 , wherein said Withania somnifera is in an amount of 8 wt. %; Sida cordifolia is in an amount of 8 wt. %; Asparagus racemosus is in an amount of 6 wt. %; Tinospora cordifolia is in an amount of 6 wt. %; Moringa oleifera is in an amount of 6 wt. %; Picrorhiza kurroa is in an amount of 6 wt. %; Ocimum sanctum is in an amount of 6 wt. %; Curcuma longa is in an amount of 7 wt. %; Piper longum is in an amount of 4 wt. %; Piper nigrum is in an amount of 4 wt. %; Zingiber officinalis is in an amount of 4 wt. %; Terminalia chebula is in an amount of 4 wt. %; Terminalia bellerica is in an amount of 4 wt. %, Emblica officinalis is in an amount of 4 wt. %; Shilajit is in an amount of 6 wt %; Abhraka Bhasma is in an amount of 2 wt. %; Trivanga Bhasma is in an amount of 1 wt %; Pravala Bhasma is in an amount of 1 wt. %; Loha Bhasma is in an amount of 2 wt. %; Swarna Makshika Bhasma is in an amount of 1 wt. %; and Gum acacia is in an amount of 10 wt. %, of the total formulation.