Sphingosine kinase type 1 inhibitors and uses thereof
Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management. These compounds are applicable to treating tumors of the central nervous system, such as glioblastoma multiforme (GBM).
1. A method for treating ulcerative colitis in a patient, comprising:
administering to a patient in need of treatment for ulcerative colitis a compound having the formula
2. The method of claim 1 , wherein the administering step comprises administering to the patient the compound having the formula
3. The method of claim 2 , wherein the administering step comprises administering the hydrochloride salt of the compound to the patient.
4. A method for treating ulcerative colitis in a patient, comprising:
administering to a patient in need of treatment for ulcerative colitis a compound having the formula
wherein R comprises a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, a hetero-aromatic ring, or any combination of the foregoing.
5. The method of claim 4 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, a hetero-aromatic ring, or any combination of the foregoing.
6. The method of claim 5 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, or a hetero-aromatic ring.
7. The method of claim 6 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, or a branched carbon chain comprising one or more heteroatoms.
8. The method of claim 7 , wherein R is a straight carbon chain or a branched carbon chain.
9. The method of claim 8 , wherein R is a straight carbon chain.
10. A method for treating colon cancer in a patient, comprising:
administering to a patient in need of treatment for colon cancer a compound having the formula
11. The method of claim 10 , wherein the administering step comprises administering to the patient the compound having the formula
12. The method of claim 11 , wherein the administering step comprises administering the hydrochloride salt of the compound to the patient.
13. A method for treating colon cancer in a patient, comprising:
administering to a patient in need of treatment for colon cancer a compound having the formula
wherein R comprises a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, a hetero-aromatic ring, or any combination of the foregoing.
14. The method of claim 13 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, a hetero-aromatic ring, or any combination of the foregoing.
15. The method of claim 14 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, or a hetero-aromatic ring.
16. The method of claim 15 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, or a branched carbon chain comprising one or more heteroatoms.
17. The method of claim 16 , wherein R is a straight carbon chain or a branched carbon chain.
18. The method of claim 17 , wherein R is a straight carbon chain.