Dry powder inhaler and system for drug delivery
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.
1. A dry powder inhaler comprising:
a sled or slide tray, a mouthpiece, and a cartridge including two or more rigid parts, wherein at least one of the two or more rigid parts is a container and another of the two or more rigid parts is a lid,
wherein movement of the mouthpiece actuates movement of the sled or slide tray and the sled or slide tray is operably configured to move the container relative to the lid from a powder containment position to a dosing position,
wherein the cartridge has at least one opening configured as an inlet and at least one opening configured as an outlet, and
wherein the container includes a dry powder including a prostaglandin.
2. The dry powder inhaler of claim 1 , wherein the prostaglandin is PG-I2.
3. The dry powder inhaler of claim 1 , wherein the dry powder includes a di ketopiperazine.
4. The dry powder inhaler of claim 3 , wherein the diketopiperazine is
5. The dry powder inhaler of claim 1 , wherein the mouthpiece is configured to engage the sled or slide tray.
6. The dry powder inhaler of claim 1 , further comprising a housing.
7. The dry powder inhaler of claim 6 , wherein the inhaler has a proximal end and a distal end, and the housing, mouthpiece and sled or slide tray are attached at the distal end of the inhaler; and the mouthpiece pivots on the housing to attain an open or loading position or a closed or dosing position.
8. The dry powder inhaler of claim 6 , wherein the inhaler comprises a gear mechanism mounted in said inhaler housing.
9. The dry powder inhaler of claim 6 , wherein the mouthpiece further has an internal volume extending from the first inlet port to the exit port greater than 0.2 cubic centimeters.
10. The dry powder inhaler of claim 6 , wherein the housing has one or more openings to allow ambient air into its interior compartment.
11. The dry powder inhaler of claim 6 , wherein the housing is substantially rectangular in shape and has an upper surface, side walls and a bottom wall forming an enclosure and comprises one or more flanges projecting in an upwardly direction from the upper surface of the housing.
12. The dry powder inhaler of claim 6 , wherein the housing has a substantially rectangular, oval, circular, or square shape.
13. The dry powder inhaler of claim 6 , wherein the housing comprises one or more grasping surfaces.
14. The dry powder inhaler of claim 6 , wherein the sled or slide tray is positioned between the mouthpiece and the housing.
15. The dry powder inhaler of claim 1 , wherein the mouthpiece actuates the sled or slide tray by rotation or translation.
16. The dry powder inhaler of claim 1 , wherein the dry powder inhaler is configured to attain an open or container loading position, and a closed or dosing position.
17. The dry powder inhaler of claim 16 , wherein the mouthpiece actuates the sled or slide tray during movement between the open position and the closed position or from the closed position to the open position.
18. The dry powder inhaler of claim 1 , wherein the sled or slide tray is attached to the mouthpiece by a hinge mechanism.
19. The dry powder inhaler of claim 18 , wherein the hinge mechanism comprises a gear or rack and pinion mechanism.
20. The dry powder inhaler of claim 1 , wherein the sled or slide tray comprises a cam.