Methods and compositions for treating viral or virally-induced conditions
Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.
1. A method for treating and/or preventing a viral or virally-induced condition comprising administering CHR-3996, wherein the CHR-3996 is administered at less than 2 mg/kg per dose, and an antiviral agent, wherein the antiviral agent is selected from the group consisting of valganciclovir, ganciclovir, acyclovir, famciclovir, and combinations thereof, wherein the viral or virally-induced condition is caused by a DNA virus.
2. The method of claim 1 , wherein the DNA virus is a herpes virus.
3. The method of claim 1 , wherein the DNA virus is an Epstein-Barr virus.
4. The method of claim 1 , wherein the DNA virus is a cytomegalovirus.
5. The method of claim 1 , wherein the DNA virus is a varicella zoster virus.
6. The method of claim 1 , wherein the viral or virally-induced condition is a cancer selected from the group of lymphoma, chronic lymphocytic leukemia, nasopharyngeal carcinoma, gastric cancer, or Kaposi's sarcoma.
7. The method of claim 1 , wherein the antiviral agent is valganciclovir.
8. The method of claim 1 , wherein the antiviral agent is ganciclovir.
9. The method of claim 1 , wherein the antiviral agent is acyclovir.
10. The method of claim 1 , wherein the antiviral agent is famciclovir.
11. The method of claim 1 , wherein the CHR-3996 and the antiviral agent are administered once daily.