Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
View Patent ↗Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
1. A composition comprising:
a compound having the formula:
wherein
R is S;
R1 is —OR5 where R5 is H or CH 3 ;
R2 is phenyl; and
R3 is 3 methylene groups,
or a pharmaceutically acceptable salt thereof, in an amount effective to increase renal progenitor cell production in a kidney of a patient; and
a pharmaceutically-acceptable excipient.
2. The composition of claim 1 , wherein the compound has the formula:
or a pharmaceutically acceptable salt thereof.
3. The composition of claim 1 , comprising a cyclodextrin complexed with the compound.
4. The composition of claim 1 , wherein the compound is 4-(phenylthio)butanoic acid.
5. A method, comprising administering the composition of claim 1 to a subject.
6. A method, comprising administering the composition of claim 2 to a subject.
7. A method, comprising administering the composition of claim 3 to a subject.
8. A method, comprising administering the composition of claim 4 to a subject.
9. A method of increasing renal progenitor cell production in a kidney of a patient, the method comprising administering the composition of claim 1 to the patient.
10. A method of increasing renal progenitor cell production in a kidney of a patient, the method comprising administering the composition of claim 2 to the patient.
11. A method of increasing renal progenitor cell production in a kidney of a patient, the method comprising administering the composition of claim 3 to the patient.
12. A method of increasing renal progenitor cell production in a kidney of a patient, the method comprising administering the composition of claim 4 to the patient.