IP Library Granted Patent US 10,682,183
Granted Patent B2
US 10,682,183 · App. 15/961,331 · Granted Jun 16, 2020

Systems and methods for correction of artificial deformation in anatomic modeling

Inventors: Leo Grady (Millbrae, CA); Michiel Schaap (Mountain View, CA); Sophie Khem (San Francisco, CA); Sarah Wilkes (Redwood City, CA); Ying Bai (Belmont, CA)
Assignee: HeartFlow, Inc.
A61B34/10G06F30/20G06K9/6215G06K9/6267G06T7/0012G06T7/60G06T7/70G09B9/00G09B23/303G16B5/00G16H50/50A61B6/5258A61B2034/105G06T13/20G06T2207/10004G06T2207/30101G06T2207/30104
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Quick Facts
Patent No.
US 10,682,183
App. No.
15/961,331
Granted
Jun 16, 2020
Kind
B2
Abstract

Systems and methods are disclosed for correcting for artificial deformations in anatomical modeling. One method includes obtaining an anatomic model; obtaining information indicating a presence of an artificial deformation of the anatomic model; identifying a portion of the anatomic model associated with the artificial deformation; estimating a non-deformed local area corresponding to the portion of the anatomic model; and modifying the portion of the anatomic model associated with the artificial deformation, based on the estimated non-deformed local area.

Claims (55)

1. A computer-implemented method of correcting anatomical modeling, the method comprising:

obtaining a plurality of patient-specific images including a vessel and a portion of myocardial tissue;

generating or receiving a vessel model based on the obtained patient-specific images;

identifying a portion of the vessel model in proximity to the portion of myocardial tissue;

determining an expected vessel size of the identified portion of the vessel model;

determining a narrowing of the vessel model by comparing a size of the identified portion of the vessel model to the determined expected vessel size; and

determining an extent of myocardial bridging, based on the narrowing of the vessel model.

2. The method of claim 1 , further including:

detecting the portion of the myocardial tissue relative to the vessel model by segmenting an image of the plurality of patient-specific images.

3. The method of claim 1 , further including:

modifying the vessel model based on the expected vessel size of the vessel model.

4. The method of claim 1 , further including:

estimating the expected vessel size by interpolating a radius between radii at multiple regions of the anatomic model, using an idealized radius, using a constant radius, using a kernel estimation, or using a database of patient data.

5. The method of claim 1 , further including:

determining a first local radiodensity of a first image of the patient-specific images;

determining a second local radiodensity of a second image of the patient-specific images; and

detecting contact between the vessel and the myocardial tissue based on a comparison of the first local radiodensity and the second local radiodensity.

6. The method of claim 3 , further including:

performing a blood flow simulation using the modified vessel model.

7. The method of claim 6 , further including:

providing a medical assessment based on the blood flow simulation.

8. A system for correcting anatomical modeling, the system comprising:

a data storage device storing instructions for correcting anatomical modeling; and

a processor configured to execute the instructions to perform a method including:

obtaining a plurality of patient-specific images including a vessel and a portion of myocardial tissue;

generating or receiving a vessel model based on the obtained patient-specific images;

identifying a portion of the vessel model in proximity to the portion of myocardial tissue;

determining an expected vessel size of the identified portion of the vessel model;

determining a narrowing of the vessel model by comparing a size of the identified portion of the vessel model to the determined expected vessel size; and

determining an extent of myocardial bridging, based on the narrowing of the vessel model.

9. The system of claim 8 , wherein the at least one computer system is further configured for:

detecting the portion of the myocardial tissue relative to the vessel model by segmenting an image of the plurality of patient-specific images.

10. The system of claim 8 , wherein the at least one computer system is further configured for:

modifying the vessel model based on the expected vessel size of the vessel model.

11. The system of claim 8 , wherein the at least one computer system is further configured for:

estimating the radius or estimating the local area by interpolating a radius between radii at multiple regions of the anatomic model, using an idealized radius, using a constant radius, using a kernel estimation, or using a database of patient data.

12. The system of claim 8 , wherein the at least one computer system is further configured for:

determining a first local radiodensity of a first image of the patient-specific images;

determining a second local radiodensity of a second image of the patient-specific images; and

detecting contact between the vessel and the myocardial tissue based on a comparison of the first local radiodensity and the second local radiodensity.

13. The system of claim 10 , wherein the at least one computer system is further configured for:

performing a blood flow simulation using the modified vessel model.

14. The system of claim 13 , wherein the at least one computer system is further configured for:

providing a medical assessment based on the blood flow simulation.

15. A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of correcting anatomical modeling, the method comprising:

obtaining a plurality of patient-specific images including a vessel and a portion of myocardial tissue;

generating or receiving a vessel model based on the obtained patient-specific images;

identifying a portion of the vessel model in proximity to the portion of myocardial tissue;

determining an expected vessel size of the identified portion of the vessel model;

determining a narrowing of the vessel model by comparing a size of the identified portion of the vessel model to the determined expected vessel size; and

determining an extent of myocardial bridging, based on the narrowing of the vessel model.

16. The non-transitory computer readable medium of claim 15 , the method further comprising:

detecting the portion of the myocardial tissue relative to the vessel model by segmenting an image of the plurality of patient-specific images.

17. The non-transitory computer readable medium of claim 15 , the method further comprising:

modifying the vessel model based on the expected vessel size of the vessel model.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Sep 11, 2025
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 072876/0775 →
RELEASE OF SECURITY INTEREST Recorded Jun 21, 2024
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 067801/0032 →
SECURITY INTEREST Recorded Jun 18, 2024
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 067775/0966 →
SECURITY INTEREST Recorded Jan 20, 2021
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 055037/0890 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 9, 2020
From: GRADY, LEO; SCHAAP, MICHIEL; KHEM, SOPHIE; WILKES, SARAH; BAI, YING
To: HEARTFLOW, INC.
Reel/Frame 051465/0700 →
Continuity (6)
Continuation 15429026 · Feb 9, 2017
Continuation 14736853 · Jun 11, 2015
Continuation 14577705 · Dec 19, 2014
Continuation 14311605 · Jun 23, 2014
Provisional Application 61985946 · Apr 29, 2014
Related Publication 20180235707A1 · Aug 23, 2018
Cited By (1)
US 12,670,998