METHODS AND APPARATUS FOR MEASURING ANALYTES
Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
1 . A method of determining pixel values comprising:
providing an array of pixels arranged in a plurality of rows and a plurality of columns;
selecting at least one row pixels to be read out of the array;
outputting pixel data for the selected rows onto buses for the columns at a first rate; and
converting pixel data from the column busses at a second rate that is multiple times the first rate such that an oversampled pixel data set is made for each pixel readout.
2 . The method of claim 1 further comprising storing the oversampled pixel data set for each of the read out pixels to create a frame of pixel data and averaging the frame of pixel data to form an average frame of pixel data.
3 . The method of claim 2 further comprising repeating the method for a plurality of rows to create a series of frames.
4 . The methods of claim 3 wherein the series of frames are averaged into a final frame.