IP Library Granted Patent US 10,442,829
Granted Patent B2
US 10,442,829 · App. 15/970,486 · Granted Oct 15, 2019

Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate

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Quick Facts
Patent No.
US 10,442,829
App. No.
15/970,486
Granted
Oct 15, 2019
Kind
B2
Abstract

A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate, methods of making the crystalline form and pharmaceutical compositions comprising the crystalline form are useful antibiotics. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium . Accordingly, the compositions comprising the crystalline form may be used in antibiotics.

Claims (1)

1. A crystalline form of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate having an x-ray powder diffraction pattern comprising the following peaks: 14.7°, 15.2°, 16.6°, 20.3°, 26.8°, and 28.2°.

Assignments (4)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →
CERTIFICATE OF CONVERSION Recorded Aug 9, 2018
From: TRIUS THERAPEUTICS, INC.
To: TRIUS THERAPEUTICS LLC
Reel/Frame 047450/0652 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2018
From: REICHENBACHER, KATHARINA; DUGUID, ROBERT J.; PHILLIPSON, DOUGLAS; SIMSON, JACQUELINE A.
To: TRIUS THERAPEUTICS
Reel/Frame 046599/0838 →
NUNC PRO TUNC ASSIGNMENT Recorded Aug 9, 2018
From: TRIUS THERAPEUTICS LLC
To: MERCK SHARP & DOHME CORP.
Reel/Frame 046599/0987 →