IP Library Granted Patent US 10,737,017
Granted Patent B2
US 10,737,017 · App. 15/972,322 · Granted Aug 11, 2020

Drug delivery device

Inventors: Amir Genosar (Boulder, CO); Doron Aurbach (Bnei Brak, IL); Elena Markevich (Rishon Lezion, IL); Grigory Salitra (Rehovot, IL); Jonathan Goldstein (Jerusalem, IL); Mikhail Levi (Givat Shmuel, IL); Niles Fleischer (Rehovot, IL); Yehuda Bachar (Givat Shmuel, IL); Yossi Aldar (Tel Aviv, IL)
Assignee: SteadyMed Ltd.
A61M5/145A61M5/14248A61M5/172A61M5/2046H01M2/02H01M10/02H01M10/05H01M10/42A61M5/1452A61M5/14276A61M5/14586A61M5/1723A61M2005/14204A61M2005/14252A61M2005/14513A61M2205/35A61M2205/8206A61M2230/201H01M2220/30
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Quick Facts
Patent No.
US 10,737,017
App. No.
15/972,322
Granted
Aug 11, 2020
Kind
B2
Abstract

The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Claims (58)

1. A self-powered drug-delivery device, the drug-delivery device comprising:

a chamber having a wall, wherein:

the chamber contains a fluid, and

the chamber is in connection with an administration means;

a displacement-generating battery cell, wherein:

said cell comprises a volume-changing element,

said cell comprising a housing formed according to a concertina-shaped design with folds in the walls thereof and containing an internal chemical reaction system,

said chemical reaction system comprising a first electrode and a second electrode,

the second electrode being said volume-changing element,

the arrangement of said chemical reaction system and said housing being such that:

an expansion of the volume-changing element in a direction lengthens the cell and thus reduces the extent of said folds,

the cell becomes taller in the direction to reflect the expansion of said volume-changing element, and

the expansion of the volume-changing element increases the surface area between the first electrode and the second electrode, and

the chemical reaction system being configured such that discharging of the cell results in the expansion of the volume-changing element in the direction;

an electrically-controlled battery unit, the electrically-controlled battery unit comprising the displacement-generating battery cell coupled to the chamber by a coupling means,

an arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber reducing the volume of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means upon charge or discharge, thereby being a self-powered drug delivery device.

2. The drug-delivery device of claim 1 , wherein:

the volume-changing element changes shape as a result of discharge of the battery cell so as to cause the displacement of the battery unit, and

the arrangement being such that the fluid is expelled from the chamber to force the drug towards the administration means upon discharge.

3. The drug-delivery device of claim 1 , wherein the fluid comprises the drug.

4. The drug-delivery device of claim 1 , wherein a vial can be inserted into the drug-delivery device.

5. The drug-delivery device of claim 4 , further comprising:

the vial, wherein:

the vial contains the drug, and

the arrangement is such that the fluid expelled from the chamber expels the drug from the vial through the administration means.

6. The drug-delivery device of claim 5 , further comprising:

a piston,

wherein:

the fluid comprises hydraulic fluid,

the coupling means is hydraulic, and

the arrangement is such that the hydraulic fluid presses the piston to expel the drug from the vial through the administration means.

7. The drug-delivery device of claim 5 , wherein the coupling means is a mechanical bar mechanism, a mechanical train, or a pulley.

8. The drug-delivery device of claim 1 , wherein:

the displacement-generating battery cell is a first displacement-generating battery cell,

the drug-delivery device further comprising:

a second displacement-generating battery cell,

wherein:

the first displacement-generating battery cell and the second displacement-generating battery cell arranged in series such that the combined displacement causes displacement of the wall.

9. The drug-delivery device of claim 8 , further comprising:

a controller that controls discharge of the battery unit, whereby on discharge, displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber, thereby reducing the volume of the chamber such that the fluid is expelled from the chamber towards the administration means,

wherein:

the drug-delivery device is a pen-shaped,

the controller is at a first end of the drug-delivery device, and

the administration means is at a second end of the drug-delivery device, the second end opposite the first end.

10. The drug-delivery device of claim 9 , wherein the housing has no space inside the housing.

11. The drug-delivery device of claim 1 , further comprising:

a bellows, a spring, or a compressible element configured to provide a counter-force to a force generated by the battery unit.

12. The drug-delivery device of claim 1 , wherein:

the wall comprises a bellows-shaped circumference.

13. The drug-delivery device of claim 1 , further comprising a pressure sensor.

14. The drug-delivery device of claim 13 , wherein the pressure sensor is disposed within the chamber, on the wall, or along a liquid path from the chamber to the administration means.

15. The drug-delivery device of claim 13 , wherein:

the pressure sensor is in electrical communication with a controller, and

the controller is configured to stop activation of the battery cell upon receiving a signal from the pressure sensor.

16. The drug-delivery device of claim 1 , wherein the chamber contains a flexible pouch, the flexible pouch containing the drug.

17. The drug-delivery device of claim 1 , wherein the coupling means is mechanical.

18. The drug-delivery device of claim 17 , wherein the coupling means involves a displaceable wall applying indirect displacement from the battery unit to the chamber.

19. The drug-delivery device of claim 1 , wherein the chamber has a diameter between 20 and 60 mm.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 15, 2022
From: STEADYMED LTD.
To: UNITED THERAPEUTICS CORPORATION
Reel/Frame 060520/0015 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2018
From: GENOSAR, AMIR; AURBACH, DORON; MARKEVICH, ELENA; SALITRA, GRIGORY; GOLDSTEIN, JONATHAN; LEVI, MIKHAIL; FLEISCHER, NILES; BACHAR, YEHUDA; ALDAR, YOSSI
To: STEADYMED LTD.
Reel/Frame 047452/0510 →
Priority Claims (1)
IL 175460 · May 7, 2006 · national
Continuity (3)
Continuation 14456416 · Aug 11, 2014
Division 12299602
Related Publication 20180250465A1 · Sep 6, 2018