Medical devices
Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).
1. A method of coating an implantable medical device, the method comprising:
activating a surface of the implantable medical device by silanization with a silane, wherein the silane includes a reactive group selected from an acrylate, methacrylate, aldehyde, epoxy, ester, or a combination thereof, and
coupling a polymer formed from a first acrylate monomer and a second monomer containing an amine, a carboxylic acid, or a hydroxyl group to the reactive group of the activated surface, wherein the first monomer is alkoxyalkyl (meth)acrylate, tetrahydrofurfuryl acrylate, or
wherein
R 1 is hydrogen,
R 2 is an alkylene group with 1 to 4 carbons, and
R 3 is an alkyl group with 1 to 4 carbons.
2. The method of claim 1 further comprising hydroxylation of the surface using oxygen plasma.
3. The method of claim 2 , wherein the oxygen plasma is applied by an oxygen flow of about 120 sccm, a power of about 500 watts, a pressure of about 400 mTorr, a time of about 5 minutes, or a combination thereof.
4. The method of claim 1 , wherein silanization occurs through reaction with a silane selected from:
or a combination thereof.
5. The method of claim 4 , wherein n is 8-12.
6. The method of claim 1 further comprising argon plasma treatment after silanization.
7. The method of claim 6 , wherein the argon plasma is applied by an argon flow of about 365 sccm, a power of about 300 watts, a pressure of about 500 mTorr, a time of about 10 minutes, or a combination thereof.
8. The method of claim 1 , wherein the coupling is by dip coating, spraying, brushing, or a combination thereof.
9. The method of claim 1 , wherein the first monomer is tetrahydrofurfuryl acrylate.
10. The method of claim 1 , wherein the second monomer is acrylic acid, methacrylic acid, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxybutyl acrylate, aminoethyl methacrylate, aminopropyl methacrylamide, a combination thereof.
11. The method of claim 1 , wherein the silane includes an epoxy reactive group.
12. The method of claim 1 , wherein the first monomer is alkoxyalkyl (meth)acrylate.
13. The method of claim 1 , wherein silanization occurs through reaction with a silane selected from:
or a combination thereof.
14. The method of claim 1 , wherein the second monomer is hydroxybutyl acrylate, aminopropyl methacrylamide, or a combination thereof.
15. The method of claim 1 , wherein the first monomer is methoxyethyl acrylate.