Methods for treating and diagnosing blinding eye diseases
This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).
1. A method for treating central serous retinopathy (CSR), comprising administering to a subject in need thereof an effective amount of a compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
each of R 1 and R 2 is independently H or a C 1 -C 6 alkyl and
R 3 is H or a C 1 -C 6 alkyl.
2. The method of claim 1 , wherein the compound of Formula I is bindarit.
3. The method of claim 1 , wherein the compound is formulated for sustained release.
4. The method of claim 1 , wherein the compound is formulated for ophthalmic administration.
5. The method of claim 1 , wherein the ophthalmic administration is intravitreal administration, intraocular administration, or effected to the ocular surface.
6. The method of claim 1 , wherein the wherein the method further comprises administering an additional therapeutic agent.
7. The method of claim 6 , wherein the additional therapeutic agent is one or more of an anti-vascular endothelial growth factor (VEGF) agent, an angiotensin-converting enzyme (ACE) inhibitor, a peroxisome proliferator-activated receptor (PPAR)-gamma agonist, a renin inhibitor, a steroid, and an agent that modulates autophagy.
8. The method of claim 1 , wherein the CSR comprises of a fluid detachment of macula layers from supporting tissue.
9. The method of claim 1 , wherein the CSR comprises of a leak of fluid from the retinal space.
10. The method of claim 1 , wherein the CSR comprises an accumulation of fluid in the subretinal or sub-retinal pigment epithelium (RPE) space.
11. The method of claim 1 , wherein the CSR comprises small breaks in the RPE.
12. The method of claim 1 , wherein the method reduces the amount of leaked fluid in the subretinal or sub-RPE space.
13. The method of claim 1 , wherein the method reduces the amount of breaks in the RPE.
14. The method of claim 1 , wherein the subject is a human.