IP Library › Granted Patent US 10,646,464
Granted Patent B2
US 10,646,464 · App. 15/981,406 · Granted May 12, 2020

Methods for treating cancer

Inventors: Chiang Jia Li (Cambridge, MA); Youzhi Li (Westwood, MA); Wei Li (Wayland, MA); Matthew Hitron (West Roxbury, MA); Yuan Gao (Belmont, MA)
Assignee: Boston Biomedical, Inc.
A61K31/343A61K31/337A61P35/00A61P35/04A61K2300/00
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Quick Facts
Patent No.
US 10,646,464
App. No.
15/981,406
Granted
May 12, 2020
Kind
B2
Abstract

Methods for treating advanced thymoma and thymic carcinoma in a subject comprising administering and kits comprising at least one paclitaxel compound and at least one compound of formula (I) (2-acetylnaphtho[2,3-b]furan-4,9-dione) as disclosed herein.

Claims (9)

1. A method for treating a advanced thymoma or thymic carcinoma in a human subject comprising administering to the subject a therapeutically effective amount of a compound of formula (I):

wherein the compound of Formula (I) is administered orally to the subject at a total daily dose of about 480 mg; and

a therapeutically effective amount of paclitaxel,

wherein paclitaxel is administered weekly.

2. The method according to claim 1 , wherein the compound of formula (I) and paclitaxel are administered to a subject simultaneously or sequentially.

3. The method according to claim 1 , wherein paclitaxel is administered at about 80 mg/m 2 weekly for 3 out of every 4 weeks as an infusion.

4. The method according to claim 1 , wherein the compound of formula (I) is administered at a dose of about 240 mg twice daily.

5. The method according to claim 1 , wherein the method is for treating thymic carcinoma.

6. The method according to claim 1 , wherein the method is for treating advanced thymoma.

Assignments (2)
CHANGE OF NAME Recorded Sep 4, 2020
From: BOSTON BIOMEDICAL, INC.
To: SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC.
Reel/Frame 053708/0635 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 24, 2019
From: LI, CHIANG JIA; LI, YOUZHI; LI, WEI; HITRON, MATTHEW; GAO, YUAN
To: BOSTON BIOMEDICAL, INC.
Reel/Frame 050820/0384 →
Continuity (2)
Provisional Application 62507353 · May 17, 2017
Related Publication 20180333385A1 · Nov 22, 2018