IP Library › Granted Patent US 11,028,139
Granted Patent B2
US 11,028,139 · App. 15/994,323 · Granted Jun 8, 2021

Recombinant protein for preventing or treating tissue fibrosis and composition for preventing or treating tissue fibrosis comprising the same

Inventors: Choong Seong Han (Seoul, KR); Dong Hun Woo (Seoul, KR); Gun Sik Cho (Daejeon, KR); Jeong Seong Kim (Hanam-si, KR); Geun Ho An (Seoul, KR); Hye Ryeon Jeon (Seongnam-si, KR)
Assignee: NEXEL CO., LTD.
C07K14/485A61K38/1709A61P1/16C07K14/47A61K38/00
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Quick Facts
Patent No.
US 11,028,139
App. No.
15/994,323
Granted
Jun 8, 2021
Kind
B2
Abstract

The present invention relates to a recombinant protein for preventing or treating tissue fibrosis, which is based on milk fat globule-EGF factor 8 (MFG-E8) protein and comprises the amino acid sequence of SEQ ID NO: 1, and to a composition for preventing or treating tissue fibrosis, which comprises the recombinant protein. The level of the effect of preventing or treating tissue fibrosis by the recombinant protein of the present invention is significantly improved compared to that of conventional milk fat globule-EGF factor 8 (MFG-E8) protein, so that the level of tissue fibrosis can be restored to a level very close to that in normal tissue by the prevention and treatment of tissue fibrosis.

Claims (2)

1. An isolated recombinant protein for preventing or treating tissue fibrosis, the recombinant protein consists of the amino acid sequence of SEQ ID NO: 1, which is a fragment of human milk fat globule-EGF factor 8 (MFG-E8) protein.

2. A composition for preventing or treating tissue fibrosis, which comprises the recombinant protein of claim 1 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 31, 2018
From: HAN, CHOONG SEONG; WOO, DONG HUN; CHO, GUN SIK; KIM, JEONG SEONG; AN, GEUN HO; JEON, HYE RYEON
To: NEXEL CO., LTD.
Reel/Frame 045952/0883 →
Priority Claims (1)
KR 10-2017-0060995 · May 17, 2017 · national
Continuity (2)
Continuation PCTKR2017005150 · May 18, 2017
Related Publication 20180334486A1 · Nov 22, 2018