TRANSDERMAL CARRIER
Improved formulations for topical treatment that ensure at least localized transdermal or systemic delivery of an active agent through skin, nails or hair follicles are disclosed.
1 . A penetrant designed to provide the following components that collectively effect transdermal delivery of an active agent in a formulation of such agent: sufficient lecithin organogel, benzyl alcohol, surfactant and polar solvent to provide a formulation of said agent that comprises benzyl alcohol at 0.5-20% w/w of said formulation, lecithin organogel at 25-70% w/w of said formulation, nonionic surfactant at 2-25% w/w of said formulation and polar solvent at least in an amount in molar excess of the nonionic surfactant.
2 . A penetrant designed to provide the following components that collectively effect transdermal delivery of an active agent in a formulation of said agent: sufficient lecithin organogel and benzyl alcohol to provide a formulation of said agent, that comprises lecithin organogel at 30%-60% w/w of said formulation and benzyl alcohol at 0.5-20% w/w of said formulation,
3 . A penetrant designed to provide the following components that collectively effect transdermal delivery of an active agent in a formulation of said agent: sufficient lecithin organogel, benzyl alcohol, surfactant, and bile salt to provide a formulation of said agent that comprises benzyl alcohol at 0.5-20% w/w of said formulation, lecithin organogel at 25-70% w/w of said formulation, nonionic surfactant at 20-60% w/w of the formulation and bile salt at 1-15% w/w of the formulation, wherein the surfactant is provided in powdered form and the formulation is essentially anhydrous.
4 . A formulation for transdermal delivery of an active agent through the skin, nail or hair follicle of a subject, which formulation comprises at least one active agent in an amount effective for treatment of a condition in said subject and the penetrant of claim 1 .
5 . A formulation for transdermal delivery of an active agent through the skin, nail or hair follicle of a subject, which formulation comprises at least one active agent in an amount effective for treatment of a condition in said subject and the penetrant of claim 2 .
6 . A formulation for transdermal delivery of an active agent through the skin, nail or hair follicle of a subject, which formulation comprises at least one active agent in an amount effective for treatment of a condition in said subject and the penetrant of claim 3 .
7 . The formulation of claim 4 wherein the lecithin organogel is a combination of soy lecithin with isopropyl palmitate.
8 . The formulation of claim 5 wherein the lecithin organogel is a combination of soy lecithin with isopropyl palmitate.
9 . The formulation of claim 6 wherein the lecithin organogel is a combination of soy lecithin with isopropyl palmitate.
10 . The formulation of claim 4 wherein the nonionic surfactant is a poloxamer and the polar solvent is water.
11 . The formulation of claim 4 and/or wherein the formulation has a pH of 9-11.
12 . The formulation of claim 5 wherein the formulation has a pH of 9-11.
13 . The formulation of claim 6 wherein the formulation has a pH of 9-11.
14 . The formulation of claim 4 wherein an active ingredient is an anesthetic, a fat-dissolving agent, a nutrient or nutrient combination, a tissue volume enhancer, a vaccine component, a hair growth modulator, an antifungal agent, an agent to promote smoking cessation, and/or a cannabinoid.
15 . The formulation of claim 5 wherein an active ingredient is an anesthetic, a fat-dissolving agent, a nutrient or nutrient combination, a tissue volume enhancer, a vaccine component, a hair growth modulator, an antifungal agent, an agent to promote smoking cessation, and/or a cannabinoid.
16 . The formulation of claim 6 wherein an active ingredient is an anesthetic, a fat-dissolving agent, a nutrient or nutrient combination, a tissue volume enhancer, a vaccine component, a hair growth modulator, an antifungal agent, an agent to promote smoking cessation, and/or a cannabinoid.
17 . A method to effect transdermal delivery of an active ingredient, which method comprises applying to the skin, nails or hair follicles of a subject an effective amount of the formulation of claim 4 .
18 . A method to effect transdermal delivery of an active ingredient, which method comprises applying to the skin, nails or hair follicles of a subject an effective amount of the formulation of claim 5 .
19 . A method to effect transdermal delivery of an active ingredient, which method comprises applying to the skin, nails or hair follicles of a subject an effective amount of the formulation of claim 6 .
20 . The method of claim 17 wherein said treating is of skin and which further includes, following said treating, applying a composition comprising linoleic acid to the area of treatment.
21 . The method of claim 18 wherein said treating is of skin and which further includes, following said treating, applying a composition comprising linoleic acid to the area of treatment.
22 . The method of claim 19 wherein said treating is of skin and which further includes, following said treating, applying a composition comprising linoleic acid to the area of treatment.