IP Library › Granted Patent US 10,913,796

Granted Patent B2

US 10,913,796 · App. 15/997,155 · Granted Feb 9, 2021

Antibodies targeting Fc receptor-like 5 and methods of use

Inventors: Renier J. Brentjens (New York, NY); Eric L. Smith (New York, NY); Cheng Liu (Emeryville, CA)

Assignees: MEMORIAL SLOAN-KETTERING CANCER CENTER; EUREKA THERAPEUTICS, INC.

C07K16/2803 A61K39/39558 A61K47/6415 A61K47/6425 A61K47/6803 A61P35/00 C07K16/283 C07K16/2809 A61K2039/572 A61K2039/585 C07K2317/21 C07K2317/31 C07K2317/34 C07K2317/622

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Quick Facts

Patent No.: US 10,913,796
App. No.: 15/997,155
Granted: Feb 9, 2021
Kind: B2

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Abstract

The presently disclosed subject matter provides fully human antibodies or antigen-binding fragments thereof that bind to FcRL5 and methods of using the same.

Claims (348)

1. An anti-Fc Receptor-Like 5 (FcRL5) antibody or an antigen-binding fragment thereof comprising:

(aa) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 312, 313, and 314, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 309, 310, and 311, respectively;

(ab) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 320, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 315, 316, and 317, respectively;

(ac) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 324, 319, and 325, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 321, 322, and 323, respectively;

(ad) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 329, 330, and 331, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 326, 327, and 328, respectively;

(ae) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 329, 330, and 331, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 332, 333, and 334, respectively;

(af) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 338, 330, and 339, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 335, 336, and 337, respectively;

(ag) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 343, 344, and 345, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 340, 341, and 342, respectively;

(ah) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 348, 349, and 350, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 347, respectively;

(ai) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 352, 344, and 353, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 351, respectively;

(aj) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 357, 358, and 359, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 354, 355, and 356, respectively;

(ak) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 363, 364, and 365, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 360, 361, and 362, respectively;

(al) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 369, 370, and 371, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 366, 367, and 368, respectively;

(am) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 329, 330, and 375, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 372, 373, and 374, respectively;

(an) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 329, 330, and 377, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 376, respectively;

(ao) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 381, 382, and 383, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 378, 379, and 380, respectively;

(ap) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 329, 385, and 386, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 309, 310, and 384, respectively;

(aq) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 390, 391, and 392, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 387, 388, and 389, respectively;

(ar) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 395, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 393, 355, and 394, respectively;

(as) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 397, 398, and 399, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 396, respectively;

(at) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 401, 398, and 402, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 400, respectively;

(au) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 406, 398, and 407, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 403, 404, and 405, respectively;

(av) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 329, 409, and 410, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 408, respectively;

(aw) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 414, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 413, respectively;

(ax) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 416, 417, and 418, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 415, respectively;

(ay) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 419, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 349, respectively;

(az) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 423, 358, and 424, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 420, 421, and 422, respectively;

(ba) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 428, 429, and 430, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 425, 426, and 427, respectively;

(bb) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 433, 434, and 435, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 372, 431, and 432, respectively;

(bc) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 423, 438, and 439, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 436, 388, and 437, respectively;

(bd) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 329, 330, and 443, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 440, 441, and 442, respectively;

(be) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 447, 448, and 449, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 444, 445, and 446, respectively;

(bf) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 452, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 309, 450, and 451, respectively;

(bg) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 369, 454, and 455, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 453, respectively;

(bh) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 457, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 456, respectively;

(bi) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 329, 330, and 331, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 458, respectively;

(bj) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 460, 461, and 462, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 459, respectively;

(bk) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 419, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 463, respectively;

(bl) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 423, 438, and 465, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 436, 388, and 464, respectively;

(bm) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 468, 469, and 470, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 466, and 467, respectively;

(bn) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 474, 358, and 465, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 471, 472, and 473, respectively;

(bo) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 477, 478, and 479, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 372, 475, and 476, respectively;

(bp) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 483, 484, and 485, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 480, 481, and 482, respectively;

(bq) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 433, 487, and 488, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 486, respectively;

(br) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 490, 313, and 491, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 309, 310, and 489, respectively;

(bs) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 312, 313, and 493, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 309, 310, and 492, respectively;

(bt) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 490, 349, and 495, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 403, 404, and 494, respectively;

(bu) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 498, 344, and 499, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 403, 496, and 497, respectively;

(bv) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 503, 504, and 505, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 500, 501, and 502, respectively;

(bw) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 508, 349, and 509, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 403, 506, and 507, respectively;

(bx) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 312, 513, and 514, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 510, 511, and 512, respectively;

(by) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 518, 319, and 519, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 515, 516, and 517, respectively;

(bz) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 348, 523, and 524, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 520, 521, and 522, respectively;

(ca) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 406, 398, and 528, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 525, 526, and 527, respectively;

(cb) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 530, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 529, respectively;

(cc) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 531, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 515, 516, and 517, respectively;

(cd) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 533, 534, and 535, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 403, 404, and 532, respectively;

(ce) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 428, 429, and 430, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 425, 426, and 536, respectively;

(cf) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 540, 398, and 541, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 537, 538, and 539, respectively;

(cg) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 406, 398, and 542, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 537, 538, and 539, respectively;

(ch) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 544, 448, and 545, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 543, respectively;

(ci) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 547, 548, and 549, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 546, respectively;

(cj) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 312, 313, and 314, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 309, 310, and 550, respectively;

(ck) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 312, 513, and 314, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 309, 310, and 550, respectively;

(cl) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 406, 398, and 554, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 551, 552, and 553, respectively;

(cm) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 556, 557, and 558, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 309, 310, and 555, respectively;

(cn) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 562, 563, and 564, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 559, 560, and 561, respectively;

(co) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 568, 504, and 569, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 565, 566, and 567, respectively;

(cp) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 571, 572, and 573, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 372, 475, and 570, respectively;

(cq) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 343, 575, and 576, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 403, 404, and 574, respectively;

(cr) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 312, 313, and 314, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 411, 412, and 577, respectively;

(cs) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 312, 313, and 314, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 578, respectively;

(ct) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 580, 438, and 581, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 436, 388, and 579, respectively;

(cu) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 585, 313, and 314, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 582, 583, and 584, respectively;

(cv) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 312, 586, and 314, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 346, 327, and 578, respectively;

(cw) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 588, 385, and 375, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 403, 404, and 587, respectively; or

(cx) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 318, 319, and 592, respectively, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NOs: 589, 590, and 591, respectively.

2. The antibody or antigen-binding fragment thereof of claim 1 , wherein:

(aa) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:3, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:4;

(ab) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:7, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:8;

(ac) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:11, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:12;

(ad) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:299, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:300;

(ae) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:15, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:16;

(af) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:19, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:20;

(ag) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:23, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:24;

(ah) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:27, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:28;

(ai) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:31, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:32;

(aj) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:35, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:36;

(ak) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:39, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:40;

(al) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:43, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:44;

(am) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:47, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:48;

(an) the x light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:51, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:52;

(ao) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:55, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:56;

(ap) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:59, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:60;

(aq) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:63, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:64;

(ar) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:67, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:68;

(as) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:71, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:72;

(at) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:75, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:76;

(au) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:79, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:80;

(av) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:83, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:84;

(aw) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:87, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:88;

(ax) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:91, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:92;

(ay) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:95, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:96;

(az) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:99, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:100;

(ba) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:103, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:104;

(bb) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:107, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:108;

(bc) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:111, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:112;

(bd) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:115, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:116;

(be) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:119, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:120;

(bf) the x light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:123, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:124;

(bg) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:127, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:128;

(bh) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:131, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:132;

(bi) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:135, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:136;

(bj) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:139, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:140;

(bk) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:143, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:144;

(bl) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:147, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:148;

(bm) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:151, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:152;

(bn) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:155, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:156;

(bo) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:159, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:160;

(bp) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:163, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:164;

(bq) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:167, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:168;

(br) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:171, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:172;

(bs) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:175, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:176;

(bt) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:179, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:180;

(bu) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:183, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:184;

(bv) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:187, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:188;

(bw) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:191, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:192;

(bx) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:195, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:196;

(by) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:199, and (b) the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:200;

(bz) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:203, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:204;

(ca) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:207, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:208;

(cb) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:211, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:212;

(cc) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:215, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:216;

(cd) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:219, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:220;

(ce) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:223, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:224;

(cf) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:227, and the heavy chain variable region the amino acid sequence set forth in SEQ ID NO:228;

(cg) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:231, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:232;

(ch) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:235, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:236;

(ci) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:239, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:240;

(cj) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:243, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:244;

(ck) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:247, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:248;

(c) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:251, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:252;

(cm) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:255, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:256;

(cn) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:259, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:260;

(co) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:263, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:264;

(cp) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:267, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:268;

(cq) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:271, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:272;

(cr) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:275, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:276;

(cs) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:279, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:280;

(ct) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:283, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:284;

(cu) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:287, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:288;

(cv) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:291, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:292;

(cw) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:303, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:304; or

(cx) the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:295, and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:296.

3. The antibody or antigen-binding fragment thereof of claim 1 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:411, SEQ ID NO:412, and SEQ ID NO:463, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:318, SEQ ID NO:319, and SEQ ID NO:419, respectively.

4. The antibody or antigen-binding fragment thereof of claim 1 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:515, SEQ ID NO:516, and SEQ ID NO:517, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:318, SEQ ID NO:319, and SEQ ID NO:531, respectively.

5. The antibody or antigen-binding fragment thereof of claim 1 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:403, SEQ ID NO:404, and SEQ ID NO:532, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:533, SEQ ID NO:534, and SEQ ID NO:535, respectively.

6. The antibody or antigen-binding fragment thereof of claim 1 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:411, SEQ ID NO:412, and SEQ ID NO:543, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:544, SEQ ID NO:448, and SEQ ID NO:545, respectively.

7. The antibody or antigen-binding fragment thereof of claim 1 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:372, SEQ ID NO:475, and SEQ ID NO:570, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:571, SEQ ID NO:572, and SEQ ID NO:573, respectively.

8. The antibody or antigen-binding fragment thereof of claim 1 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:440, SEQ ID NO:441, and SEQ ID NO:442, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:329, SEQ ID NO:330, and SEQ ID NO:443, respectively.

9. The antibody or antigen-binding fragment thereof of claim 1 , wherein the heavy chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:309, SEQ ID NO:310, and SEQ ID NO:489, respectively; and the light chain variable region comprises a CDR1, a CDR2, and a CDR3 sequence set forth in SEQ ID NO:490, SEQ ID NO:313, and SEQ ID NO:491, respectively.

10. The antibody or antigen-binding fragment thereof of claim 2 , wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:143; and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:144.

11. The antibody or antigen-binding fragment thereof of claim 2 , wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:215; and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:216.

12. The antibody or antigen-binding fragment thereof of claim 2 , wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:219; and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:220.

13. The antibody or antigen-binding fragment thereof of claim 2 , wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:235; and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:236.

14. The antibody or antigen-binding fragment thereof of claim 2 , wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:267; and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:268.

15. The antibody or antigen-binding fragment thereof of claim 2 , wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:115; and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:116.

16. The antibody or antigen-binding fragment thereof of claim 2 , wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:171; and the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:172.

17. The antibody or antigen-binding fragment thereof of claim 2 , wherein the antigen-binding fragment is an scFv.

18. A composition comprising the antibody or antigen-binding fragment thereof of claim 1 , and a pharmaceutically acceptable carrier.

19. A composition comprising the antibody or antigen-binding fragment thereof of claim 2 , and a pharmaceutically acceptable carrier.

20. The antibody or antigen-binding fragment thereof of claim 1 , wherein the antigen-binding fragment is an scFv.

21. The antibody or antigen-binding fragment thereof of claim 20 , further comprising a peptide linker, wherein the antibody or antigen-binding fragment thereof comprises the amino acid sequence set forth in SEQ ID NO:594, SEQ ID NO:596, SEQ ID NO:598, SEQ ID NO:600, SEQ ID NO:602, SEQ ID NO:604, SEQ ID NO:606, SEQ ID NO:608, SEQ ID NO:610, SEQ ID NO:612, SEQ ID NO:614, SEQ ID NO:616, SEQ ID NO:618, SEQ ID NO:620, SEQ ID NO:622, SEQ ID NO:624, SEQ ID NO:626, SEQ ID NO:628, SEQ ID NO:630, SEQ ID NO:632, SEQ ID NO:634, SEQ ID NO:636, SEQ ID NO:638, SEQ ID NO:640, SEQ ID NO:642, SEQ ID NO:644, SEQ ID NO:646, SEQ ID NO:648, SEQ ID NO:650, SEQ ID NO:652, SEQ ID NO:654, SEQ ID NO:656, SEQ ID NO:658, SEQ ID NO:660, SEQ ID NO:662, SEQ ID NO:664, SEQ ID NO:666, SEQ ID NO:668, SEQ ID NO:670, SEQ ID NO:672, SEQ ID NO:674, SEQ ID NO:676, SEQ ID NO:678, SEQ ID NO:680, SEQ ID NO:682, SEQ ID NO:684, SEQ ID NO:686, SEQ ID NO:688, SEQ ID NO:690, SEQ ID NO:692, SEQ ID NO:694, SEQ ID NO:696, SEQ ID NO:698, SEQ ID NO:700, SEQ ID NO:702, SEQ ID NO:704, SEQ ID NO:706, SEQ ID NO:708, SEQ ID NO:710, SEQ ID NO:712, SEQ ID NO:714, SEQ ID NO:716, SEQ ID NO:718, SEQ ID NO:720, SEQ ID NO:722, SEQ ID NO:724, SEQ ID NO:726, SEQ ID NO:728, SEQ ID NO:730, SEQ ID NO:732, SEQ ID NO:734, SEQ ID NO:736, SEQ ID NO:738, SEQ ID NO:740, SEQ ID NO:742, or SEQ ID NO:744.

22. The antibody or antigen-binding fragment thereof of claim 21 , wherein the antibody or antigen-binding fragment thereof comprises the amino acid sequence set forth in SEQ ID NO: 650, SEQ ID NO:664, SEQ ID NO:678, SEQ ID NO:700, SEQ ID NO:702, SEQ ID NO:710, or SEQ ID NO:726.

23. An anti-Fc Receptor-Like 5 (FcRL5) antibody or an antigen-binding fragment thereof comprising:

(aa) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:3, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:4;

(ab) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:7, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:8;

(ac) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:11, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:12;

(ad) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:299, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:300;

(ae) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:15, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:16;

(af) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:19, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:20;

(ag) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:23, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:24;

(ah) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:27, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:28;

(ai) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:31, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:32;

(aj) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:35, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:36;

(ak) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:39, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:40;

(al) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:43, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:44;

(am) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:47, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:48;

(an) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:51, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:52;

(ao) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:55, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:56;

(ap) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:59, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:60;

(aq) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:63, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:64;

(ar) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:67, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:68;

(as) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:71, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:72;

(at) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:75, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:76;

(au) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:79, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:80;

(av) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:83, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:84;

(aw) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:87, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:88;

(ax) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:91, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:92;

(ay) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:95, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:96;

(az) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:99, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:100;

(ba) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:103, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:104;

(bb) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:107, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:108;

(bc) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:111, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:112;

(bd) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:115, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:116;

(be) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:119, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:120;

(bf) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:123, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:124;

(bg) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:127, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:128;

(bh) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:131, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:132;

(bi) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:135, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:136;

(bj) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:139, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:140;

(bk) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:143, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:144;

(bl) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:147, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:148;

(bm) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:151, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:152;

(bn) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:155, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:156;

(bo) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:159, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:160;

(bp) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:163, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:164;

(bq) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:167, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:168;

(br) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:171, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:172;

(bs) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:175, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:176;

(bt) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:179, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:180;

(bu) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:183, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:184;

(bv) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:187, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:188;

(bw) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:191, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:192;

(bx) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:195, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:196;

(by) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:199, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:200;

(bz) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:203, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:204;

(ca) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:207, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:208;

(cb) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:211, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:212;

(cc) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:215, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:216;

(cd) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:219, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:220;

(ce) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:223, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:224;

(cf) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:227, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:228;

(cg) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:231, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:232;

(ch) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:235, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:236;

(ci) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:239, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:240;

(cj) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:243, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:244;

(ck) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:247, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:248;

(cl) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:251, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:252;

(cm) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:255, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:256;

(cn) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:259, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:260;

(co) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:263, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:264;

(cp) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:267, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:268;

(cq) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:271, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:272;

(cr) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:275, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:276;

(cs) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:279, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:280;

(ct) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:283, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:284;

(cu) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:287, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:288;

(cv) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:291, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:292;

(cw) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:303, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:304; or

(cx) a light chain variable region comprising a CDR1, a CDR2, and a CDR3 of the light chain variable region sequence set forth in SEQ ID NO:295, and a heavy chain variable region comprising a CDR1, a CDR2, and a CDR3 of the heavy chain variable region sequence set forth in SEQ ID NO:296.

24. The antibody or antigen-binding fragment thereof of claim 23 , wherein:

(aa) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:3, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:4;

(ab) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:7, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:8;

(ac) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:11, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:12;

(ad) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:299, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:300;

(ae) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:15, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:16;

(af) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:19, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:20;

(ag) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:23, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:24;

(ah) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:27, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:28;

(ai) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:31, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:32;

(aj) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:35, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:36;

(ak) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:39, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:40;

(al) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:43, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:44;

(am) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:47, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:48;

(an) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:51, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:52;

(ao) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:55, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:56;

(ap) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:59, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:60;

(aq) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:63, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:64;

(ar) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:67, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:68;

(as) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:71, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:72;

(at) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:75, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:76;

(au) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:79, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:80;

(av) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:83, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:84;

(aw) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:87, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:88;

(ax) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:91, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:92;

(ay) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:95, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:96;

(az) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:99, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:100;

(ba) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:103, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:104;

(bb) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:107, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:108;

(bc) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:111, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:112;

(bd) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:115, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:116;

(be) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:119, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:120;

(bf) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:123, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:124;

(bg) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:127, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:128;

(bh) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:131, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:132;

(bi) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:135, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:136;

(bj) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:139, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:140;

(bk) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:143, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:144;

(bl) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:147, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:148;

(bm) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:151, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:152;

(bn) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:155, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:156;

(bo) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:159, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:160;

(bp) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:163, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:164;

(bq) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:167, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:168;

(br) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:171, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:172;

(bs) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:175, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:176;

(bt) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:179, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:180;

(bu) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:183, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:184;

(bv) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:187, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:188;

(bw) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:191, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:192;

(bx) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:195, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:196;

(by) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:199, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:200;

(bz) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:203, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:204;

(ca) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:207, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:208;

(cb) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:211, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:212;

(cc) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:215, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:216;

(cd) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:219, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:220;

(ce) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:223, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:224;

(cf) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:227, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:228;

(cg) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:231, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:232;

(ch) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:235, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:236;

(ci) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:239, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:240;

(cj) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:243, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:244;

(ck) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:247, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:248;

(cl) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:251, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:252;

(cm) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:255, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:256;

(cn) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:259, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:260;

(co) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:263, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:264;

(cp) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:267, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:268;

(cq) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:271, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:272;

(cr) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:275, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:276;

(cs) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:279, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:280;

(ct) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:283, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:284;

(cu) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:287, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:288;

(cv) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:291, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:292;

(cw) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:303, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:304; or

(cx) the light chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:295, and the heavy chain variable region comprises an amino acid sequence that has at least about 90% sequence identity to the sequence set forth in SEQ ID NO:296.

25. The antibody or antigen-binding fragment thereof of claim 23 , which is a fully human or an antigen-binding fragment thereof, a chimeric antibody or an antigen-binding fragment thereof, or a humanized antibody or an antigen-binding fragment thereof.

26. The antibody or antigen-binding fragment thereof of claim 23 , wherein the antigen-binding fragment is a Fab, Fab′, F(ab′) 2 , Fv or single chain fragment variable (scFv).

27. The antibody or antigen-binding fragment thereof of claim 23 , wherein the FcRL5 is a human FcRL5.

28. The antibody or antigen-binding fragment thereof of claim 23 , wherein the antibody or antigen-binding fragment thereof binds to an epitope comprising the amino acid sequence set forth in SEQ ID NO:915 or SEQ ID NO:916.

29. A composition comprising the antibody or antigen-binding fragment thereof of claim 23 , and a pharmaceutically acceptable carrier.

30. An immunoconjugate comprising the antibody or antigen-binding fragment thereof of claim 23 , linked to a therapeutic agent.

31. The immunoconjugate of claim 30 , wherein the therapeutic agent is a drug, cytotoxin, or a radioactive isotope.

32. A composition comprising the immunoconjugate of claim 30 and a pharmaceutically acceptable carrier.

33. A bispecific molecule comprising the antibody or antigen-binding fragment thereof of claim 23 , linked to a second functional moiety.

34. The bispecific molecule of claim 33 , wherein the second functional moiety has a different binding specificity than said antibody or antigen-binding fragment thereof.

35. The bispecific molecule of claim 33 , wherein the second functional moiety has a binding specificity for an immune cell.

36. The bispecific molecule of claim 33 , wherein the second functional moiety has a binding specificity for CD3.

37. A kit for treating a B cell cancer, comprising the antibody or antigen-binding fragment thereof of claim 23 .

38. A composition comprising the bispecific molecule of claim 33 and a pharmaceutically acceptable carrier.

39. The kit of claim 37 , wherein the kit further comprises written instructions for using the antibody or antigen-binding fragment thereof for treating a subject having a B cell cancer.

40. The kit of claim 37 , wherein the B cell cancer is multiple myeloma or Waldenstrom's Macroglobulinemia.

41. The kit of claim 40 , wherein the B cell cancer is multiple myeloma.

42. The antibody or antigen-binding fragment thereof of claim 23 , wherein the antigen-binding fragment is an scFv.

43. The antibody or antigen-binding fragment thereof of claim 42 , wherein the antibody or antigen-binding fragment comprises a peptide linker positioned between the light chain variable region and the heavy chain variable region.

44. The antibody or antigen-binding fragment thereof of claim 43 , wherein the antibody or antigen-binding fragment comprises, in N-terminal to C-terminal order, the light chain variable region, the peptide linker and the heavy chain variable region.

Assignments (3)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2021

From: LIU, CHENG

To: EUREKA THERAPEUTICS, INC.

Reel/Frame 056285/0849 →

CONFIRMATORY PATENT ASSIGNMENT Recorded Apr 14, 2021

From: SMITH, ERIC L.

To: MEMORIAL SLOAN-KETTERING CANCER CENTER

Reel/Frame 055928/0159 →

CONFIRMATORY PATENT ASSIGNMENT Recorded Mar 11, 2021

From: BRENTJENS, RENIER J.

To: MEMORIAL SLOAN-KETTERING CANCER CENTER