Dietary product devoid of at least two non essential amino acids
The present invention relates to a dietary product comprising a plurality of amino acids, wherein the dietary product comprises all the essential amino acids and wherein the dietary product is substantially devoid of at least two non-essential amino acids; methods and uses thereof in the treatment of cancer; stratification methods and biomarkers for such applications.
1. A dietary product comprising:
all essential amino acids, which consist of: histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine, or prodrugs, salts, or esters of said amino acids;
at least three additional amino acids selected from alanine, asparagine, aspartic acid, glutamic acid, glutamine, and proline, or prodrugs, salts, or esters of said amino acids;
and optionally, further comprising one or more of the amino acids tyrosine or arginine, or prodrugs, salts, or esters of said amino acids;
wherein the dietary product is devoid of the amino acids glycine, serine, and cysteine, and prodrugs, salts, and esters of said amino acids.
2. The dietary product of claim 1 , wherein the dietary product is further devoid of arginine, or a prodrug, a salt, or an ester thereof.
3. The dietary product of claim 1 , wherein the dietary product further comprises one or more macronutrients or one or more micronutrients.
4. The dietary product of claim 1 , wherein the dietary product is formulated as a solid.
5. A pharmaceutical composition comprising:
a. the dietary product of claim 1 ; and
b. a pharmaceutically acceptable carrier, a pharmaceutically acceptable excipient, or a pharmaceutically acceptable diluent.
6. The dietary product of claim 1 , wherein the dietary product is further devoid of arginine, or a prodrug, a salt, or an ester thereof, and tyrosine, or a prodrug, a salt, or an ester thereof.
7. The dietary product of claim 1 , wherein the dietary product is further devoid of tyrosine, or a prodrug, a salt, or an ester thereof.
8. The dietary product of claim 1 , wherein the dietary product further comprises methionine, or a salt, or an ester thereof, at a level of less than 25 mg/kg/day.
9. The dietary product of claim 3 , wherein the one or more macronutrient is a fat.
10. The dietary product of claim 3 , wherein the one or more micronutrient is magnesium.
11. The dietary product of claim 3 , wherein the one or more micronutrient is calcium.
12. The dietary product of claim 3 , wherein the one or more micronutrient is potassium.
13. The dietary product of claim 1 , wherein the dietary product is formulated as a beverage.
14. The dietary product of claim 1 , wherein the dietary product comprises alanine, or a prodrug, a salt, or an ester thereof.
15. The dietary product of claim 1 , wherein the dietary product comprises arginine, or a prodrug, a salt, or an ester thereof.
16. The dietary product of claim 1 , wherein the dietary product comprises asparagine, or a prodrug, a salt, or an ester thereof.
17. The dietary product of claim 1 , wherein the dietary product comprises aspartic acid, or a prodrug, a salt, or an ester thereof.
18. The dietary product of claim 1 , wherein the dietary product comprises glutamic acid, or a prodrug, a salt, or an ester thereof.
19. The dietary product of claim 1 , wherein the dietary product comprises glutamine, or a prodrug, a salt, or an ester thereof.
20. The dietary product of claim 1 , wherein the dietary product comprises proline, or a prodrug, a salt, or an ester thereof.
21. The dietary product of claim 1 , wherein the dietary product comprises tyrosine, or a prodrug, a salt, or an ester thereof.
22. The dietary product of claim 1 , wherein the dietary product decreases proliferation rate of a cancer cell.