Method and apparatus for the production of lead 212 for medical use
The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
1. An apparatus for an automated production of lead-212 in a closed system, comprising:
a sealed box;
a generator comprising a solid medium and radium-224 to produce lead-212 by decay of the radium-224, the radium-224 being bound to the solid medium; and
a collector for collecting the purified lead-212;
the sealed box comprising:
an extractor for extracting the lead-212 from the generator to form an aqueous solution A1;
a liquid chromatography column for purifying the lead-212 comprised by the aqueous solution A1 from radiological and chemical impurities;
a first connector for connecting the generator with the extractor;
a second connector for connecting the extractor with the liquid chromatography column;
a third connector for connecting the liquid chromatography column with the collector; and
an electronic processor for commanding the extractor, the liquid chromatography column and the first, second and third connectors;
the generator and the collector being outside the sealed box, the sealed box comprising an inlet port for allowing the first connector to connect the generator with the extractor, and an outlet port for allowing the third connector to connect the liquid chromatography column with the collector.
2. The apparatus of claim 1 , wherein the extractor comprises a circulator for circulating an aqueous solution in the generator.
3. The apparatus of claim 2 , wherein the circulator comprises a pump to draw in the aqueous solution and to inject the drawn aqueous solution into the generator.
4. The apparatus of claim 1 , wherein the liquid chromatography column comprises a stationary phase which selectively retains the lead-212 from the aqueous solution A1.
5. The apparatus of claim 4 , wherein the liquid chromatography column further comprises an eluter for eluting the lead-212 from the stationary phase.
6. The apparatus of claim 5 , wherein the eluter for eluting the lead-212 from the stationary phase comprises a circulator for circulating an aqueous solution A3 in the chromatography column.
7. The apparatus of claim 6 , wherein the circulator comprises a pump to draw in the aqueous solution A3 and to inject the drawn aqueous solution A3 into the liquid chromatography column.
8. The apparatus of claim 3 , wherein the pump is further provided for drawing in an aqueous solution A2 and for injecting the drawn aqueous solution A2 into the liquid chromatography column to wash the stationary phase.
9. The apparatus of claim 6 , wherein the collector comprises a flask.
10. The apparatus of claim 9 , further comprising a bacteriological purification filter which is placed between the flask and the liquid chromatography column.
11. The apparatus of claim 1 , wherein the sealed box further comprises a plurality of inlet ports, each inlet port being provided to be connected to an aqueous solution source, and a fail-safe device to prevent connecting an aqueous solution source to a port with which it is not associated.