Controlled sympathectomy and micro-ablation systems and methods

1. A system, comprising:

a tool comprising:

one or more microfingers having substantially elongate structures;

a plurality of sensing tips electrically and mechanically coupled to the one or more microfingers, the plurality of sensing tips configured to interface with a wall of a lumen coupled to an organ of a subject; and

a control unit embedded into one of the one or more microfingers;

a feedback system coupled with the tool;

wherein the control unit of the tool is configured:

to apply a procedure to a first region in a vicinity of the lumen via delivery of at least one of energy and a chemical utilizing at least one of the plurality of sensing tips; and

to apply a subsequent procedure to a second region in the vicinity of the lumen via delivery of at least one of energy and a chemical utilizing at least one of the plurality of sensing tips;

to monitor one or more physiologic parameters of the subject utilizing at least one of the plurality of sensing tips after application of the subsequent procedure;

to condition one or more signals representing the monitored physiologic parameters utilizing a microcircuit electrically coupled to at least one of the plurality of sensing tips; and

to convey the conditioned one or more signals representing the monitored physiologic parameters to the feedback system; and

wherein the feedback system is configured:

to determine one or more changes in the physiologic parameters utilizing the conditioned one or more signals conveyed from the tool; and

to convey an outcome of the procedure to an operator based upon the determined changes in the physiologic parameters.

2. The system of claim 1 , wherein the first region and the second region are substantially collocated with each other.

3. The system of claim 1 , wherein the second region is located closer to the organ than the first region.

4. The system of claim 1 , wherein the feedback system is configured to indicate to the operator a successful outcome for the procedure if the physiologic parameter does not substantially change during a predetermined period following application of the subsequent procedure.

5. The system of claim 4 , wherein the predetermined period is longer than 5 seconds.

6. The system of claim 1 , wherein the feedback system is configured to indicate to the operator an unsuccessful outcome for the procedure if the physiologic parameter substantially changes during a predetermined period following application of the subsequent procedure.

7. The system of claim 1 , wherein at least one of the first region and the second region substantially surround the circumference of the lumen.

8. The system of claim 1 , wherein at least one of the procedure and the subsequent procedure comprises at least one of an ablation, an excision, a cut, a burn, a radio frequency ablation, freezing, a microwave ablation, radiosurgery, an ultrasonic ablation, an abrasion, a biopsy, and delivery of a substance.

9. The system of claim 1 , wherein the monitored physiologic parameters comprise at least one of water concentration, tone, blood oxygen saturation of local tissues, evoked potential, electrolyte or solute concentration, stimulation of nervous activity, sensing of nervous activity, electromyography, temperature, blood pressure, vasodilation, vessel wall stiffness, muscle sympathetic nerve activity (MSNA), central sympathetic drive, a mechanomyographic signal, a local field potential, an electroacoustic event, central sympathetic drive, tissue tone, and nerve traffic.

10. The system of claim 1 , wherein a timespan between application of the procedure and application of the subsequent procedure is longer than 5 seconds.

11. The system of claim 1 , wherein the tool is further configured to apply one or more additional subsequent procedures to one of the first region and the second region utilizing at least one of the plurality of sensing tips.

12. The system of claim 1 , wherein the feedback system is configured to indicate to the operator a durable outcome for the procedure if a given one of the monitored physiologic parameters does not substantially change during a predetermined period following application of the one or more additional subsequent procedures.

13. The system of claim 1 , wherein the plurality of sensing tips comprise a balloon catheter comprising a balloon with a surface, the balloon shaped and dimensioned for placement within the lumen, the balloon comprising one or more energy elements and chemical delivery elements arranged along the surface thereof, the one or more energy elements and chemical delivery elements configured to perform at least one of the procedure and the subsequent procedure.

14. The system of claim 13 , wherein the one or more energy elements and chemical delivery elements are arranged along a length of the balloon and around a circumference of the balloon.

15. The system of claim 1 , wherein at least one of the procedure and the subsequent procedure comprises at least one of a denervation and a neuromodulation procedure, and the feedback system is configured to convey the outcome of the procedure as an assessment of a durability of the at least one denervation and neuromodulation procedure.

16. The system of claim 1 , wherein the one or more microfingers are configured such that a first subset of the plurality of sensing tips bias against the wall of the lumen in the first region while a second subset of the plurality of sensing tips bias against the wall of the lumen in the second region during a single placement of the tool.

17. The system of claim 1 , wherein the one or more microfingers are configured such that the plurality of sensing tips bias against the wall of the lumen in the first region during a first placement of the tool and bias against the wall of the lumen in the second region during a second placement of the tool.

18. A tool comprising:

one or more microfingers having substantially elongate structures;

a plurality of sensing tips electrically and mechanically coupled to the one or more microfingers, the plurality of sensing tips configured to interface with a wall of a lumen coupled to an organ of a subject; and

a control unit embedded into one of the one or more microfingers, the control unit being configured:

to apply a procedure to a first region in a vicinity of the lumen via delivery of at least one of energy and a chemical utilizing at least one of the plurality of sensing tips; and

to apply a subsequent procedure to a second region in the vicinity of the lumen via delivery of at least one of energy and a chemical utilizing at least one of the plurality of sensing tips;

to monitor one or more physiologic parameters of the subject utilizing at least one of the plurality of sensing tips after application of the subsequent procedure;

to condition one or more signals representing the monitored physiologic parameters utilizing a microcircuit electrically coupled to at least one of the plurality of sensing tips; and

to convey the conditioned one or more signals representing the monitored physiologic parameters to a feedback system for determining one or more changes in the physiologic parameters indicating an outcome of the procedure.

19. The tool of claim 18 , wherein the plurality of sensing tips comprise a balloon catheter comprising a balloon with a surface, the balloon shaped and dimensioned for placement within the lumen, the balloon comprising one or more energy elements and chemical delivery elements arranged along the surface thereof, the one or more energy elements and chemical delivery elements configured to perform at least one of the procedure and the subsequent procedure.

20. The tool of claim 19 , wherein the one or more energy elements and chemical delivery elements are arranged along a length of the balloon and around a circumference of the balloon.