Anti-Tie2 antibodies and uses thereof
The present invention provides antibodies that bind to Tie2 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human Tie2 and block the interaction between Tie2 and one or more Tie2 ligands such as angiopoietin 1 (Ang1), angiopoietin 2 (Ang2), angiopoietin 3 (Ang3) and/or angiopoietin 4 (Ang4). The antibodies of the invention are useful, inter alia, for the treatment of diseases and disorders associated with one or more Tie2 biological activities including angiogenesis.
1. An isolated antibody or antigen-binding fragment thereof that specifically binds human Tie2, comprising the complementarity determining regions (CDRs), HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, of an antibody produced from a cell line deposited with the American Type Culture Collection under accession number PTA-12296.
2. The isolated antibody or antigen-binding fragment of claim 1 , comprising the variable regions of an antibody produced from a cell line deposited with the American Type Culture Collection under accession number PTA-12296.
3. The isolated antibody or antigen-binding fragment of claim 1 that is an antibody.
4. The isolated antibody of claim 3 that is an IgG1 antibody.
5. The isolated antibody of claim 3 that is an IgG4 antibody.
6. The isolated antibody or antigen-binding fragment of claim 1 that is an antigen-binding fragment.
7. The isolated antibody or antigen-binding fragment of claim 1 that is multispecific.