Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

1. A compound of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein:

Q is a pyridin-2-yl, pyridin-3-yl, or pyridin-4-yl, each of which is substituted with one R a ;

R 2 , R 3 , and R 4 are each hydrogen;

Y is CH 2 ;

X is O or CH 2 ;

R 5 is halo or OH;

R 6 and R 7 together form oxo;

R a is heteroaryl substituted with one to three R c ; and

each R c is independently selected from the group consisting of C 1-8 alkyl and haloC 1-8 alkyl.

2. The compound of claim 1 , wherein X is 0.

3. The compound of claim 1 , wherein R 5 is OH.

4. The compound of claim 1 , wherein R a is substituted with one R c , and R c is C 1-6 alkyl or haloC 1-6 alkyl.

5. The compound of claim 2 , wherein:

Q is pyridin-3-yl substituted with one R a .

6. The compound of claim 5 , wherein R a is heteroaryl having two nitrogen ring atoms.

7. The compound of claim 6 , wherein R a is substituted with one R c , and R c is C 1-6 alkyl or haloC 1-6 alkyl.