Dosing regimens for echinocandin class compounds
The invention features pharmaceutical compositions, methods, and kits featuring dosing gimens and oral dosage formulations for administration of echinocandin class compounds.
1. A method of treating a subject having or susceptible to a fungal infection comprising administering to the subject an aqueous solution comprising compound 22 having the formula
or a pharmaceutically acceptable salt thereof, wherein the aqueous solution is administered to the subject intravenously at an interval of one dose every 5 to 8 days, in an amount that is sufficient to treat the fungal infection.
2. The method of claim 1 , wherein the interval is one dose every 7 days.
3. The method of claim 1 , wherein the aqueous solution is intravenously administered for at least two intervals over a period of at least two weeks.
4. The method of claim 3 , wherein the aqueous solution is intravenously administered for at least four weeks.
5. The method of claim 3 , wherein the aqueous solution is intravenously administered for at least eight weeks.
6. The method of claim 3 , wherein the aqueous solution is intravenously administered for at least twelve weeks.
7. The method of claim 1 , wherein the pharmaceutically acceptable salt of compound 22 is an acetate salt.
8. The method of claim 1 , wherein the subject is being prepared for an invasive medical procedure, is immunocompromised, or is undergoing long-term antibiotic therapy.
9. The method of claim 8 , wherein the invasive medical procedure is a transplant, a stem cell therapy, a graft, a prosthesis, an intravenous catheterization, or treatment in an intensive care unit.