19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein , R 1 , R 2 , R 3a , R 3b , R 4a , R 4b , R 5 , R 6 , and R 7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
1. A method of treating a sleep disorder or a mood disorder in a human subject in need thereof, comprising administering to the human subject a therapeutically effective amount of a compound of the formula
2. The method of claim 1 , wherein the method is a method of treating a sleep disorder.
3. The method of claim 2 , wherein the sleep disorder is insomnia.
4. The method of claim 1 , wherein the method is a method of treating a mood disorder.
5. The method of claim 4 , wherein the mood disorder is depression.
6. The method of claim 1 , wherein the compound is administered orally.
7. A method of treating a sleep disorder or a mood disorder in a human subject in need thereof, comprising administering to the human subject a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula
and a pharmaceutically acceptable excipient.
8. The method of claim 7 , wherein the method is a method of treating a sleep disorder.
9. The method of claim 8 , wherein the sleep disorder is insomnia.
10. The method of claim 7 , wherein the method is a method of treating a mood disorder.
11. The method of claim 10 , wherein the mood disorder is depression.
12. The method of claim 7 , wherein the pharmaceutical composition is administered orally.
13. A method of treating postnatal depression in a human subject in need thereof, comprising administering to the human subject a therapeutically effective amount of a compound of the formula.
14. The method of claim 13 , wherein the compound is administered orally.
15. A method of treating postnatal depression in a human subject in need thereof, comprising administering to the human subject a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula
and a pharmaceutically acceptable excipient.
16. The method of claim 15 , wherein the pharmaceutical composition is administered orally.