Cyclic peptide conjugates and methods of use
The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound adduct, a method for treating disorders such as proliferation disorders (e.g., malignancies), bone deficiency diseases, and autoimmune diseases, and a method for suppressing the growth of, or inducing apoptosis in, cells (e.g., malignant cells).
1. A carrying agent:cyclic compound adduct having the structure:
wherein X comprises a carrying agent and z is 1 to 20.
2. The carrying agent:cyclic compound adduct of claim 1 , wherein said carrying agent comprises an amino acid, oligo(amino acid), poly(amino acid) or protein.
3. A composition comprising a cyclic compound of claim 2 ; and a pharmaceutically acceptable carrier.