Kinase inhibitors
There are provided compounds of formula IIb, wherein: LG 1 represents imidazolyl, chloro, or aryloxy; and Z 1 represents a structural fragment of formula V: wherein R 2 to R 4 , R 5a , L and X 1 to X 3 have meanings given in the description, or a salt or protected derivative thereof, wherein said protected derivative is a compound in which the carboxyl moiety of R 4 is protected as a C 1-8 alkyl ester. The compounds have antiinflammatory activity, for example through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
1. A compound of formula IIb,
wherein:
LG 1 represents imidazolyl, chloro, or aryloxy; and
Z 1 represents a structural fragment of formula V:
wherein:
R 2 and R 3 , together with the C-atoms to which they are attached, form a fused phenyl ring;
X 1 , X 2 and X 3 all represent CH;
L represents a direct bond;
R 5a represents methoxy; and
R 4 represents —CO 2 H,
or a salt or protected derivative thereof, wherein said protected derivative is a compound in which the carboxyl moiety of R 4 is protected as a C 1-8 alkyl ester.
2. A compound as claimed in claim 1 , wherein LG 1 represents phenoxy.
3. A compound as claimed in claim 1 , wherein Z 1 represents a structural fragment of formula Vp
wherein:
R 4′ represents a C 1-4 alkyl group; and
R 2 , R 3 , X 1 , X 2 , X 3 , L and R 5a are as defined in claim 1 .
4. A compound as claimed in claim 3 , wherein R 4′ represents a C 1-3 alkyl group.
5. A compound as claimed in claim 1 , wherein the carboxyl moiety of R 4 is protected as an ethyl or methyl ester.
6. A compound as claimed in claim 1 , wherein the carboxyl moiety of R 4 is protected as a methyl ester.