IP Library Granted Patent US 11,439,810
Granted Patent B2
US 11,439,810 · App. 16/039,071 · Granted Sep 13, 2022

Tunable neural electrode

Inventors: Corey Edward Cruttenden (Minneapolis, MN); Rajesh Rajamani (Saint Paul, MN); Wei Chen (Plymouth, MN); Xiao-Hong Zhu (Plymouth, MN); Mahdi Ahmadi (Minneapolis, MN)
Assignee: Regents of the University of Minnesota
A61N1/0534A61B5/24A61B5/7207A61N1/0551A61N1/086A61B5/6868A61B5/6877A61B2562/125A61N1/36003A61N1/36053A61N1/36062A61N1/36067A61N1/36103
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Quick Facts
Patent No.
US 11,439,810
App. No.
16/039,071
Granted
Sep 13, 2022
Kind
B2
Abstract

A device includes a substrate, an electrode, an electrical pad, and a signal line. The signal line is coupled to the substrate and covered by an insulation layer. The signal line is coupled to the electrical pad and the electrode. At least one of the electrode and the signal line includes a diamagnetic material and paramagnetic material, wherein a ratio of the diamagnetic material and the paramagnetic material is selected based on the susceptibility properties of a physiological tissue. The term paramagnetic herein refers to magnetic susceptibility greater than that of the surrounding tissue and diamagnetic refers to magnetic susceptibility lower than that of the tissue.

Claims (38)

1. A device comprising:

a substrate having a surface;

a signal line coupled to the substrate and covered by an insulation layer;

an electrical pad coupled to the signal line; and

an electrode coupled to the signal line, the electrode comprising a network of randomly oriented conductive nanorods of diamagnetic material and paramagnetic material, wherein diamagnetic and paramagnetic are relative to a physiological tissue, wherein a ratio of the diamagnetic material and the paramagnetic material is selected based on a physiological susceptibility property of the tissue.

2. The device of claim 1 , wherein the physiological tissue is a neural or spinal tissue, and the electrode is part of an array of neural electrodes.

3. The device of claim 1 , wherein the physiological tissue includes a muscular tissue.

4. The device of claim 1 , where the electrode is a recording electrode or a stimulating electrode.

5. The device of claim 1 , wherein the signal line includes a network of randomly oriented conductive materials configured to reduce eddy current generation in a MRI system.

6. A fabrication method comprising:

providing a substrate having a surface;

forming a signal line coupled to the substrate;

forming an electrical pad coupled to the signal line;

forming an electrode, such that the electrode is coupled to the signal line, the electrode comprises a network of randomly oriented conductive nanorods of diamagnetic material and paramagnetic in a ratio based on a physiological susceptibility property of a physiological tissue, wherein diamagnetic and paramagnetic are relative to the physiological tissue; and

applying an insulation layer to the signal line.

7. The method of claim 6 , wherein the ratio is a volumetric ratio.

8. The method of claim 6 , further comprising:

selecting the ratio to substantially match the magnetic susceptibility with that of the physiological tissue.

9. The method of claim 6 , wherein forming the electrode includes depositing layers of the diamagnetic and paramagnetic materials.

10. The method of claim 6 , wherein forming the electrode includes forming layers of diamagnetic material and paramagnetic material to substantially match the physiological susceptibility property of the physiological tissue.

11. The method of claim 6 , wherein forming the electrode includes diffusion of the paramagnetic and diamagnetic materials to substantially match the physiological susceptibility property of the physiological tissue.

12. The method of claim 6 , wherein forming the electrode includes evaporating and heating.

13. The method of claim 6 , wherein forming the electrode includes co-depositing the diamagnetic material and the paramagnetic material.

14. The method of claim 6 , wherein forming the signal line includes forming the signal line to include a network of randomly oriented conductive materials selected from the group consisting of: conductive nanorods, nanomaterials, and micro-structured conductive materials.

15. The method of claim 6 , further comprising:

forming a variety of MRI-compatible and biocompatible electrodes with particular susceptibility that substantially matches the tissue susceptibility for neural recording and brain stimulation with minimal MRI susceptibility artifacts or reduced eddy current and tissue heating.

16. A neural electrode array device comprising:

a substrate;

a signal line coupled to the substrate;

an insulation layer covering the signal line;

an electrical pad coupled to the signal line; and

an electrode coupled to the signal line,

wherein the electrode includes a network of randomly oriented conductive nanorods of diamagnetic material and paramagnetic material configured to reduce eddy current generation in a MRI system, wherein diamagnetic and paramagnetic are relative to a neural tissue.

17. The device of claim 16 , wherein the signal line is fabricated of a material having a susceptibility property corresponding to neural tissue.

18. The device of claim 16 , wherein the electrode includes a layer of carbon nanotubes at an exposed surface.

19. The device of claim 16 , wherein the electrode includes a layer of electrically conductive polymer at an exposed surface.

20. The device of claim 16 , wherein the electrode includes a layer of biocompatible conductive material at an exposed surface.

21. The device of claim 16 , wherein the substrate has a magnetic susceptibility that substantially matches that of the neural tissue.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2020
From: RAJAMANI, RAJESH
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 052882/0846 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 9, 2019
From: CHEN, WEI; ZHU, XIAO-HONG
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 050663/0777 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 4, 2019
From: CRUTTENDEN, COREY EDWARD; AHMADI, MAHDI
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 050626/0655 →
CONFIRMATORY LICENSE Recorded Feb 1, 2019
From: UNIVERSITY OF MINNESOTA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 048228/0885 →
Continuity (2)
Provisional Application 62533873 · Jul 18, 2017
Related Publication 20190022375A1 · Jan 24, 2019
Cited By (1)
US 12,437,189