IP Library › Granted Patent US 11,008,551
Granted Patent B2
US 11,008,551 · App. 16/054,590 · Granted May 18, 2021

Method to increase the infectivity of virus particles

Inventors: Thomas Shenk (Princeton, NJ); Nicole Gudleski O'Regan (Hatboro, PA); Todd M. Greco (Langhorne, PA); Ileana M. Cristea (Princeton, NJ)
Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
C12N7/00C12Q1/705A61K39/25C12N2710/16151
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Quick Facts
Patent No.
US 11,008,551
App. No.
16/054,590
Granted
May 18, 2021
Kind
B2
Abstract

A method for enhancing infectivity of HCMV virus particles is provided.

Claims (2)

1. An in vitro method for production of virus particles in a virus-infected host cell comprising the step of contacting the cell with siRNA that decreases activity of LRP1, wherein the virus particles produced in the cell in the presence of the siRNA display increased infectivity compared to virus particles produced in the cell in the absence of the siRNA, and wherein the siRNA decreases the level of LRP1 protein.

2. An in vitro method for production of virus particles in a virus-infected host cell comprising the step of contacting the cell with siRNA that increases intracellular cholesterol, wherein the virus particles produced in the cell in the presence of the siRNA display increased infectivity compared to virus particles produced in the cell in the absence of the siRNA, and wherein the siRNA decreases the level of LRP1 protein.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jan 31, 2019
From: PRINCETON UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 048199/0097 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2018
From: CRISTEA, ILEANA M.; GRECO, TODD M.; SHENK, THOMAS; O'REGAN, NICOLE GUDLESKI
To: THE TRUSTEES OF PRINCETON UNIVERSITY
Reel/Frame 046924/0371 →
Continuity (3)
Continuation 14233810
Provisional Application 61510298 · Jul 21, 2011
Related Publication 20180346885A1 · Dec 6, 2018