Intraocular delivery devices and methods therefor
Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.
1. A method of loading a drug into a drug reservoir, comprising:
providing a drug vial comprising a stopper and the drug within a vial cavity;
providing a drug reservoir injector comprising a distal port and the drug reservoir;
loading the drug reservoir with the drug from the vial through a needle assembly; removing the needle assembly from the drug reservoir system; and
connecting the drug reservoir injector with an injector attachment comprising:
a needle hub comprising a tubular body and comprising an input port on its proximal end for removable connection to the injector, and a distal stop surface;
a needle comprising a proximal portion and a distal portion, the proximal portion of the needle housed within the tubular body of the needle hub, and the distal end of the needle extending distally beyond the needle hub;
a rigid slidable shield comprising a distal opening, a proximal opening, and an uninterrupted sidewall between the distal opening and the proximal opening configured to protect the sterility of the needle and operatively coupled to the needle hub and having a fixed axial dimension, the slidable shield configured for axial movement along the needle hub between the input port and the distal stop surface and configured such that the needle is completely circumscribed by the shield and the distal portion of the needle hub when the shield is in a first, distal position with respect to the needle hub, and the distal portion of the needle extends distally beyond the shield when the shield is in a second, proximal position with respect to the needle hub,
a patient contact surface, the patient contact surface comprising a perimeter and located at a distal end of the slidable shield; and
a lever attached to the needle hub, the lever configured to prevent axial movement of the slidable shield and to maintain the shield in the first, distal position with respect to the needle hub by a locking shoulder at a distal end of the lever contacting a proximal end wall of the slidable shield thereby preventing proximal movement of the shield away from the first, distal position.
2. The method of claim 1 , wherein the input port comprises a luer lock.
3. The method of claim 1 , wherein the drug reservoir comprises a syringe.