Methods for decreasing chord length
The methods and assays described herein relate to the diagnosis, prognosis, and treatment of subjects with emphysema, COPD, and/or cigarette-induced lung damage. In some embodiments, the methods and assays relate to subjects with a decreased level of NLRX1 expression. In some embodiments, the methods and assays relate to the administration of an agonist of NLRX1 and/or an inhibitor of MAVS.
1. A method of decreasing chord length in the lung of a subject in need of treatment for alveoli loss, the method comprising administering an inhibitor of Mitochondrial AntiViral Signaling protein (MAVS), wherein the inhibitor of MAVS is a NOD-Like Receptor family member X1 (NLRX1) agonist comprising a nucleic acid encoding NLRX1, and
wherein the subject is a subject determined to have a decreased level of NLRX1 expression determined using a method selected from the group consisting of: RT-PCR; quantitative RT-PCR; Northern blot; microarray-based expression analysis; next-generation sequencing; and RNA in situ hybridization.
2. The method of claim 1 , wherein the level of NLRX1 is determined by measuring the level of NLRX1 RNA transcript.