Multi-site concurrent ultrasound blood flow velocity measurement for continuous hemodynamic management

1. A Doppler ultrasound device comprising:

a Doppler ultrasound instrument including:

ultrasound pulse control and data acquisition electronics configured to acquire Doppler ultrasound data;

an N-channel connector port configured to simultaneously operatively connect up to N ultrasound transducer patches with the ultrasound pulse control and data acquisition electronics where N is an integer equal to or greater than two, wherein each ultrasound transducer patch includes an ultrasound transducer array comprising ultrasound transducers; and

an electronic processor programmed to concurrently determine up to N blood flow velocities corresponding to up to N ultrasound transducer patches operatively connected to the N-channel connector port from Doppler ultrasound data acquired using the respective ultrasound transducer patches,

wherein the electronic processor is further programmed to determine the blood flow velocity for each ultrasound transducer patch by operations including:

determining a transducer blood flow velocity for each ultrasound transducer of an array of ultrasound transducers of the ultrasound transducer patch from Doppler ultrasound data acquired using the ultrasound transducer; and

determining the blood flow velocity for the ultrasound transducer patch as a highest determined transducer blood flow velocity of the array of ultrasound transducers or as an aggregation of a set of highest determined transducer blood flow velocities of the array of ultrasound transducers;

wherein the electronic processor of the Doppler ultrasound instrument is further programmed to determine a blood flow lumen by operations including:

mapping the array of ultrasound transducers of the ultrasound transducer patch that define an array area; and

determining the blood flow lumen from a map of the determined transducer blood flow velocities over the array area;

wherein the electronic processor of the Doppler ultrasound instrument is further programmed to determine flow mediated dilation (FMD) based on change in the determined blood flow lumen over time.

2. The Doppler ultrasound device of claim 1 wherein the ultrasound pulse control and data acquisition electronics includes one of:

(1) a multiplexor switchable to sequentially connect the ultrasound pulse control and data acquisition electronics with each channel of the N-channel connector port; and

(2) N electronics channels each connecting with a corresponding channel of the N-channel connector port.

3. The Doppler ultrasound device of claim 1 wherein the N-channel connector port includes one of:

(1) N connectors each configured to connect with a single ultrasound transducer patch; and

(2) one connector configured to connect with an N-to-1 pigtail connector of a bundle of N ultrasound transducer patches.

4. The Doppler ultrasound device of claim 1 wherein the electronic processor of the Doppler ultrasound instrument is further programmed to determine a blood flow in a trunk blood vessel connecting with B branch blood vessels where B is at least two and B is less than or equal to N by operations including:

determining B blood flow velocities corresponding to B ultrasound transducer patches operatively connected to the N-channel connector port from Doppler ultrasound data acquired using the respective ultrasound transducer patches; and

computing the blood flow in the trunk blood vessel using the determined B blood flow velocities and blood vessel lumens for the B branch blood vessels.

5. The Doppler ultrasound device of claim 1 wherein the electronic processor of the Doppler ultrasound instrument is further programmed to simultaneously assess hemodynamic response to a stimulus in K different blood vessels where K is at least two and K is less than or equal to N by operations including:

determining blood flow velocity as a function of time for K ultrasound transducer patches operatively connected to the N-channel connector port from Doppler ultrasound data acquired using the respective ultrasound transducer patches; and

determining the hemodynamic response to the stimulus for each of the K different blood vessels based on the K determined blood flow velocities as a function of time.

6. The Doppler ultrasound device of claim 1 further comprising:

N ultrasound transducer patches, each connectable to the N-channel connector port of the Doppler ultrasound instrument to operatively connect with the ultrasound pulse control and data acquisition electronics simultaneously with up to N−1 of the other N ultrasound transducer patches.

7. The Doppler ultrasound device of claim 1 further comprising:

between two and N ultrasound transducer patches simultaneously connected to the N-channel connector port of the Doppler ultrasound instrument and thereby simultaneously operatively connected with the ultrasound pulse control and data acquisition electronics.

8. The Doppler ultrasound device of claim 6 wherein each ultrasound transducer patch includes an adhesive by which the ultrasound transducer patch is operatively connectable to skin of a hemodynamic measurement subject.

9. A Doppler ultrasound method comprising:

affixing two or more ultrasound transducer patches, wherein each ultrasound transducer patch includes an ultrasound transducer array comprising ultrasound transducers, to different locations on a hemodynamic measurement subject;

concurrently acquiring Doppler ultrasound data using the two or more ultrasound transducer patches affixed to the different locations on the hemodynamic measurement subject; and

determining a blood flow velocity for each location using the Doppler ultrasound data acquired using the ultrasound transducer patch affixed to the location, wherein the blood flow velocity is determined for each location by operations including:

determining a transducer blood flow velocity for each ultrasound transducer of each array of ultrasound transducers using Doppler ultrasound data acquired using the ultrasound transducer; and

determining the blood flow velocity for the ultrasound transducer patch as a highest determined transducer blood flow velocity of the array of ultrasound transducers or as an aggregation of a set of highest determined transducer blood flow velocities of the array of ultrasound transducers; and

mapping the array of ultrasound transducers of the ultrasound transducer patch that define an array area; and

determining a blood flow lumen from a map of the determined transducer blood flow velocities over the array area; and

determining flow mediated dilation (FMD) based on change in the determined blood flow lumen over time.

10. The Doppler ultrasound method of claim 9 wherein the plurality of different locations on the hemodynamic measurement subject align with locations of branching blood vessels that connect with a trunk blood vessel and the method further comprises:

determining blood flows in the branching blood vessels from the blood flow velocities determined for the different locations on the hemodynamic measurement subject; and

computing a blood flow in the trunk blood vessel by adding together the determined blood flows in the branching blood vessels.

11. The Doppler ultrasound method of claim 9 further comprising:

applying a stimulus to the hemodynamic measurement subject;

determining the blood flow velocities for the different locations on the hemodynamic measurement subject as a function of time at least after applying the stimulus; and

determining a hemodynamic response to the stimulus for each of a plurality of different blood vessels based on the blood flow velocities as a function of time at the different locations on the hemodynamic measurement subject.

12. The Doppler ultrasound method of claim 11 wherein the stimulus is a fluid challenge.

13. The Doppler ultrasound method of claim 9 further comprising:

automatically repeating the concurrent acquiring and the determining at a programmed automatic repetition time interval; and

plotting a trend line for each determined blood flow velocity as a function of time.