IP Library › Granted Patent US 10,512,638
Granted Patent B2
US 10,512,638 · App. 16/062,500 · Granted Dec 24, 2019

3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor

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Quick Facts
Patent No.
US 10,512,638
App. No.
16/062,500
Granted
Dec 24, 2019
Kind
B2
Abstract

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine 5 receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Claims (8)

1. A compound which is:

or a pharmaceutically acceptable salt thereof.

2. A compound which is:

3. The compound of claim 1 which is substituted with a 11 C isotope.

4. The compound of claim 2 which is substituted with a 11 C isotope.

5. A compound which is:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 5 which is:

Assignments (7)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2018
From: BAO, JIANMING
To: MSD R & D (CHINA) CO., LTD
Reel/Frame 047827/0734 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2018
From: LI, CHUNSING
To: WUXI APP TEC (TIANJIN) CO., LTD.
Reel/Frame 047830/0644 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2018
From: WUXI APP TEC (TIANJIN) CO., LTD.
To: MERCK SHARP & DOHME CORP.
Reel/Frame 047831/0375 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2018
From: ACTON, JOHN J., III; KNOWLES, SANDRA L.; LO, MICHAEL MAN-CHU; MAZZOLA, ROBERT D., JR.; SELYUTIN, OLEG
To: MERCK SHARP & DOHME CORP.
Reel/Frame 047744/0497 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2018
From: EGBERTSON, MELISSA; HARRISON, SCOTT T.; RUDD, MICHAEL T.; TELLERS, DAVID M.; TONG, LING
To: MERCK SHARP & DOHME CORP.
Reel/Frame 047742/0738 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2018
From: GAO, XIAOLEI; MENG, ZHAOYANG; WAI, JENNY MIU-CHUN
To: MERCK SHARP & DOHME CORP.
Reel/Frame 047744/0010 →