Small molecules for inhibiting chemokine activity and/or cancer cells growth
Compounds capable of, or usable in, inducing death of cancer cells and/or modulating a biological activity of a chemokine e.g., cell migration, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or inhibiting a kinase and/or in treating a disease or disorder associated with an activity of a kinase, such as cancer and inflammatory diseases and disorders, are provided herein. The compounds are collectively represented by Formulae Ia or Ib: wherein A, B D, E, G and R 1 -R 5 are as defined in the specification.
1. A compound represented by Formula Ia and/or Ib:
wherein:
A is an alkyl being at least 4 carbon atoms in length;
B is selected from hydroxy and alkoxy;
D, E and G are each independently selected from hydrogen, hydroxy, alkoxy and alkyl, provided that (i) no more than one of D, E and G is said alkyl, (ii) at least one and no more than two of D, E and G are said alkoxy, and (iii) if two of D, E and G are said alkoxy, none of D, E and G is said alkyl;
R 1 is selected from hydrogen and alkyl; and
each of R 2 -R 5 is independently selected from hydrogen, hydroxy, halo, alkoxy, thioalkoxy, thiol, thioalkoxy and amine.
2. The compound of claim 1 , wherein B is alkoxy.
3. The compound of claim 1 , wherein E is alkoxy.
4. The compound of claim 2 , wherein E is alkoxy.
5. The compound of claim 1 , wherein D is alkoxy.
6. The compound of claim 2 , wherein D is alkoxy.
7. The compound of claim 3 , wherein D is alkoxy.
8. The compound of claim 4 , wherein D is alkoxy.
9. The compound of claim 1 , wherein G is alkoxy.
10. The compound of claim 1 , wherein G is hydrogen.
11. The compound of claim 1 , wherein B is alkoxy, E is alkoxy and G is alkoxy or hydrogen.
12. The compound of claim 11 , wherein D is alkoxy.
13. The compound of claim 1 , wherein D is said alkyl.
14. The compound of claim 13 , wherein G is hydrogen.
15. The compound of claim 13 , wherein B is alkoxy.
16. The compound of claim 13 , wherein B is alkoxy and E is alkoxy.
17. The compound of claim 1 , wherein when one of D, E and G is alkyl, said alkyl is at least 4 carbon atoms in length.
18. The compound of claim 1 , being:
19. The compound of claim 1 , being:
20. The compound of claim 1 , being:
21. The compound of claim 1 , being: