IP Library Granted Patent US 12,529,631
Granted Patent B2
US 12,529,631 · App. 16/065,254 · Granted Jan 20, 2026

Device for staining 3D biopsy tissue

Inventors: Pieter Jan Van Der Zaag (Waalre, NL); Roland Cornelis Martinus Vulders (Eindhoven, NL); Danielle Elisa Willemine Clout (Eindhoven, NL); Johannes Theodorus Wilhelmus Maria Van Eemeren (Helmond, NL); Anja Van De Stolpe (Vught, NL)
Assignee: KONINKLIJKE PHILIPS N.V.
G01N1/31A61B10/0096A61B10/0275A61B10/0283G01N21/11G01N2021/052
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Quick Facts
Patent No.
US 12,529,631
App. No.
16/065,254
Granted
Jan 20, 2026
Kind
B2
Abstract

A method and system for processing a 3D tissue sample is provided, comprising the steps of receiving a tube with an inner space and two open ends, wherein the tube is configured to retain the 3D tissue sample in the inner space, arranging the tube so that one of the two open ends of the tube is located at a fluid channel, and forcing or actively pressing a tissue processing agent through the fluid channel and into the tube so that the tissue processing agent passes through the tissue.

Claims (18)

1 . A system for processing an intact 3D tissue sample, comprising:

a tube, the tube having a first open end, a second open end and an inner space dimensioned to accommodate the 3D tissue sample,

a tube retainer, and

a pump arranged to supply a tissue processing fluid under pressure into the tube,

wherein, when the tube is retained by the tube retainer, one of the first and second open ends of the tube is arranged so that the tissue processing fluid is suppliable into the tube and the tissue processing fluid is forced through the 3D tissue sample while the 3D tissue sample is accommodated and retained in the tube;

wherein the tube has a length between 5 mm and 20 mm.

2 . A system for processing an intact 3D tissue sample, comprising:

a tube, the tube having a first open end, a second open end and an inner space dimensioned to accommodate the 3D tissue sample,

a tube retainer, and

a pump arranged to supply a tissue processing fluid under pressure into the tube,

wherein, when the tube is retained by the tube retainer, one of the first and second open ends of the tube is arranged so that the tissue processing fluid is suppliable into the tube and the tissue processing fluid is forced through the 3D tissue sample while the 3D tissue sample is accommodated and retained in the tube;

wherein the tube has an outer diameter of up to 2 mm.

3 . A system for processing an intact 3D tissue sample, comprising:

a tube, the tube having a first open end, a second open end and an inner space dimensioned to accommodate the 3D tissue sample,

a tube retainer, and

a pump arranged to supply a tissue processing fluid under pressure into the tube,

wherein, when the tube is retained by the tube retainer, one of the first and second open ends of the tube is arranged so that the tissue processing fluid is suppliable into the tube and the tissue processing fluid is forced through the 3D tissue sample while the 3D tissue sample is accommodated and retained in the tube;

wherein the tube has an outer diameter of up to 1 mm.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 22, 2018
From: VAN DER ZAAG, PIETER JAN; VULDERS, ROLAND CORNELIS MARTINUS; CLOUT, DANIELLE ELISA WILLEMINE; VAN EEMEREN, JOHANNNES THEODORUS WILHELMUS MARIA; VAN DE STOLPE, ANJA
To: KONINKLIJKE PHILIPS N.V.
Reel/Frame 046175/0257 →
Priority Claims (1)
EP 15202666 · Dec 24, 2015 · regional
Continuity (1)
Related Publication 20210270705A1 · Sep 2, 2021
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