IP Library › Granted Patent US 10,800,780

Granted Patent B2

US 10,800,780 · App. 16/065,397 · Granted Oct 13, 2020

TDO2 Inhibitors

Inventors: Xingyu Lin (Beijing, CN); Po-wai Yuen (Beijing, CN); Rohan Mendonca (South San Francisco, CA); Brendan Parr (South San Francisco, CA); Richard Pastor (South San Francisco, CA); Zhonghua Pei (South San Francisco, CA); Lewis Gazzard (South San Francisco, CA); Firoz Jaipuri (Ames, IA); Sanjeev Kumar (Ames, IA); Xiaokai Li (Ames, IA); Roheeth Pavana (Ames, IA); Hima Potturi (Ames, IA); Venkata Velvadapu (Ames, IA); Jesse Waldo (Ames, IA); Zuhui Zhang (Ames, IA); Guosheng Wu (Beijing, CN); Benjamin Douglas Sellers (South San Francisco, CA)

Assignees: Genentech, Inc.; NewLink Genetics Corporation

C07D487/04 A61K38/16 A61K45/06 A61P35/00 C07D519/00 A61K2300/00

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Quick Facts

Patent No.: US 10,800,780
App. No.: 16/065,397
Granted: Oct 13, 2020
Kind: B2

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Abstract

Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

Claims (1013)

1. A compound of formula (I):

or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof,

wherein

R 1 is

wherein the hydroxy moiety is bonded to the A ring, and each R a is independently a substituent of the A ring or the B ring;

ring A is C 3-8 cycloalkyl or 3-7 membered heterocyclyl, and

the hydroxy moiety is bonded to the A ring and each R a is independently a substituent of the A ring or the B ring;

wherein, unless stated otherwise above,

ring A is C 3-10 cycloalkyl or 3-7 membered heterocyclyl, and

ring B is C 3-7 cycloalkyl, 3-7 membered heterocyclyl, aryl or heteroaryl,

m is 0, 1, 2, 3 or 4,

R 4 is —OH,

each R a is independently selected from oxo, halogen, cyano, nitro, C 1-6 alkyl, —C 1-6 haloalkyl, C 1-6 alkyl-cyano, —OR, —NR 2 , —SR, —C(O)OR, —C(O)N(R) 2 , —C(O)R, —S(O)R, —S(O)OR, —S(O)N(R) 2 , —S(O) 2 R, —S(O) 2 OR, —S(O) 2 N(R) 2 , —OC(O)R, —OC(O)OR, —OC(O)N(R) 2 , —N(R)C(O)R, —N(R)C(O)OR, and —N(R)C(O)N(R) 2 ;

n is 0 or 1;

each R 2 is independently halogen, cyano, C 1-6 alkyl, C 3 cycloalkyl, —C 1-6 haloalkyl, —OR, —NR 2 or —SR; and

each R is independently hydrogen, C 1-6 alkyl or C 1-6 haloalkyl.

2. A compound of formula (I),

wherein R 1 is

wherein R 3 is methyl, ethyl, propyl, butyl, —O-methyl, —O-ethyl, —O-propyl, or —O-butyl;

wherein R 3 is a methyl, ethyl, propyl, or butyl;

R 4 is —OH;

n is 0 or 1;

each R 2 is independently hydrogen, C 1-6 alkyl or C 1-6 haloalkyl.

3. The compound of claim 1 , wherein each R a is independently selected from halogen, C 1-6 alkyl, —OR, —S(O) 2 R and —S(O) 2 N(R) 2 .

4. The compound of claim 1 , wherein n is 1.

5. The compound of claim 1 , wherein each R 2 is independently halogen.

6. The compound of claim 2 , wherein R 2 is halogen.

7. The compound of any of claim 1 , wherein n is 0.

8. The compound of claim 1 of formula (Ie):

9. A compound that is

2-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol,

7-(5H-imidazo[4,3-a]isoindol-5-yl)-5H,6H,7H,8H-imidazo[1,5-a]pyridin-8-ol,

6-(5H-imidazo[4,3-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol,

1-(3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethan-1-one,

tert-butyl 3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

tert-butyl 4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

1-(4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethan-1-one,

2-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

2-(4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

1-(ethylsulfonyl)-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

1-(ethylsulfonyl)-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

4,4-difluoro-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-2,3-dihydro-1H-inden-1-ol,

2-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclopentan-1-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

2-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

2-(3-hydroxy-4-(-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)pyrrolidine-1-sulfonamide,

9-hydroxy-8-(5H-imidazo[5,1-a]isoindol-5-yl)-6,7,8,9-tetrahydro-4H-quinolizin-4-one,

4-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-amine,

4-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol,

3-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-methylcyclobutan-1-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)bicyclo[2.2.2]octan-2-ol,

3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrothiophene 1,1-dioxide,

3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-sulfonamide,

1-(ethylsulfonyl)-4-(5H-imidazo[5,1-a]isoindol-5-yl)pyrrolidin-3-ol,

tert-butyl 7-hydroxy-6-(5H-imidazo[1,5-b]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)thietan-3-ol,

1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)oxetan-3-ol,

3,3-difluoro-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

4,4-difluoro-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

3,3-bis(fluoromethyl)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

2-(4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

3-(5H-imidazo[5,1-a]isoindol-5-yl)-4-methyltetrahydro-2H-pyran-4-ol,

5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol,

1-(5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

4-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

3-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

1-(cyclopropylsulfonyl)-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

3-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methylpiperidine-1-sulfonamide,

3-(7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

4-(7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

8-(ethylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

1-(cyclopropylsulfonyl)-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethylpiperidine-1-sulfonamide,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(isopropylsulfonyl)piperidin-3-ol,

1-(cyclopropylsulfonyl)-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(2,2,2-trifluoroethyl)piperidin-3-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-methylpiperidin-3-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2,5,5-tetramethyltetrahydrofuran-3-ol,

4-(5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(isopropylsulfonyl)piperidin-3-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-2,6,6-trimethylcyclohexan-1-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)azepan-4-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

2-(fluoromethyl)-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)thiochromane 1,1-dioxide,

5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

4-(9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)azepane-1-sulfonamide,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(oxetan-3-yl)piperidin-3-ol,

5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

8-hydroxy-7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

2,2-difluoro-6-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

8-hydroxy-7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile,

3-((5H-imidazo[5,1-a]isoindol-5-yl)methyl)-1-(ethylsulfonyl)azetidin-3-ol,

2-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

4-(7-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

2-amino-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

8-hydroxy-7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

7-(ethylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-7-azaspiro[3.5]nonan-1-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)pyrrolidin-3-ol,

7-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

3-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-4-ol,

4-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

4-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

2-amino-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

8-hydroxy-7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoxalin-5-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-5,6,7,8-tetrahydroquinazolin-5-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-4-ol,

7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol,

tert-Butyl 3-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

1-(5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

1-(5H-imidazo[5,1-a]isoindol-5-yl)-4,4-dimethylcyclohexan-1-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridin-4-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-7-ol,

4-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carboxamide,

8-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

2-(5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

3-(5H-Imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

4-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carbonitrile,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridin-4-ol,

7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-ol,

1-(5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

3,3-bis(fluoromethyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

3-fluoro-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

1-(hydroxy(5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carbonitrile,

3-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylpropanamide,

4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbonitrile,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

3-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutane-1,2-diol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

3-chloro-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

2-amino-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

1-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

1-(hydroxy(5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carboxamide,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]oxazol-4-ol,

8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

3-(9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

4-(8-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide,

2-(difluoromethyl)-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carbonitrile,

7-(5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-5,6,7,8-tetrahydroisoquinolin-8-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

6-(5H-imidazo[5,1-a]isoindol-5-yl)-3-(methylsulfonyl)-3-azabicyclo[3.1.1]heptan-6-ol,

5-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]oxazol-4-ol,

8-(methylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

1-hydroxy-2-(5H-imidazo[4,3-a]isoindol-5-yl)-7-azaspiro[3.5]nonane-7-sulfonamide,

8-(methylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol, or

6-(5H-imidazo[5,1-a]isoindol-5-yl)-2-(methylsulfonyl)-2-azaspiro[3.3]heptan-5-ol,

or a pharmaceutically acceptable salt thereof, or an enantiomer or diastereoisomer thereof, or a racemic mixture thereof.

10. A compound that is

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(7S,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(7S,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(7R,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(7R,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(7R,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(7R,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(7S,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(7S,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(3R,4R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

(3R,4R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

(3S,4S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol,

(3R,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol,

(3S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol,

(3R,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol,

(7S,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol,

(7R,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol,

(7S,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol,

(7R,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol,

(7S,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol,

(7R,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol,

(7R,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol,

(7S,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol,

(5S,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol;

(5R,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol;

(5R,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol,

(5S,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol,

(5R,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol,

(5S,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol,

(5S,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol,

(5R,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol,

1-(3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethan-1-one,

tert-butyl (3S,4S)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

tert-butyl (3R,4R)-3-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

tert-butyl (3R,4R)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

tert-butyl (3S,4S)-3-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

(3S,4R)-tert-butyl 4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

(3R,4S)-tert-butyl 4-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

tert-butyl (3R,4S)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

tert-butyl (3S,4R)-4-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

1-((3S,4R)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethanone,

1-((3R,4S)-4-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethanone,

1-((3R,4S)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethanone,

1-((3S,4R)-4-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethanone,

(1R,2S)-2-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2S)-2-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1R,2R)-2-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2R)-2-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2R)-2-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1R,2R)-2-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2S)-2-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1R,2S)-2-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

2-((3S,4R)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3R,4S)-4-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3R,4S)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3S,4R)-4-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

(3S,4R)-1-(ethylsulfonyl)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

(3R,4S)-1-(ethylsulfonyl)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

(3R,4S)-1-(ethylsulfonyl)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

(3S,4R)-1-(ethylsulfonyl)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

(3S,4S)-1-(ethylsulfonyl)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

(3R,4R)-1-(ethylsulfonyl)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

(3R,4R)-1-(ethylsulfonyl)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol,

(1S,2S)-4,4-difluoro-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,2S)-4,4-difluoro-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,2R)-4,4-difluoro-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,2R)-4,4-difluoro-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,2S)-4,4-difluoro-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,2S)-4,4-difluoro-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,2R)-4,4-difluoro-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,2R)-4,4-difluoro-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,3-dihydro-1H-inden-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,3-dihydro-1H-inden-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,3-dihydro-1H-inden-1-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,3-dihydro-1H-inden-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,3-dihydro-1H-inden-1-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,3-dihydro-1H-inden-1-ol,

(1S,2R)-2-[(5R)-8-fluoro-5H-imidazo[4,3-a]isoindol-5-yl]cyclopentan-1-ol,

(1S,2R)-2-[(5S)-8-fluoro-5H-imidazo[4,3-a]isoindol-5-yl]cyclopentan-1-ol,

(1R,2S)-2-[(5R)-8-fluoro-5H-imidazo[4,3-a]isoindol-5-yl]cyclopentan-1-ol,

(1R,2S)-2-[(5S)-8-fluoro-5H-imidazo[4,3-a]isoindol-5-yl]cyclopentan-1-ol,

(1R,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

(1R,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

(1R,4S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

(1R,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

(1S,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

(1S,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

(1S,4S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

(1S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(1R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclopentan-1-ol,

(1R,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclopentan-1-ol,

(1R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclopentan-1-ol,

(1S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclopentan-1-ol,

(1S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclopentan-1-ol,

(1S,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclopentan-1-ol,

(1R,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(1S,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(1R,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(1S,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(1R,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(1S,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(1R,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(1S,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(1R,2S)-2-[(5S)-8-fluoro-5H-imidazo[4,3-a]isoindol 5-yl]cyclohexan-1-ol,

(1S,2R)-2-[(5S)-8-fluoro-5H-imidazo[4,3-a]isoindol 5-yl]cyclohexan-1-ol,

(1S,2R)-2-[(5R)-8-fluoro-5H-imidazo[4,3-a]isoindol-5-yl]cyclohexan-1-ol,

(1R,2S)-2-[(5R)-8-fluoro-5H-imidazo[4,3-a]isoindol-5-yl]cyclohexan-1-ol,

(3R,4S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3S,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3R,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3S,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3S,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3R,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3S,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

2-((3S,4S)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3R,4R)-3-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3R,4R)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3S,4S)-3-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

(3R,4R)-3Hydroxy-4-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]pyrrolidine-1-sulfonamide,

(3R,4R)-3-hydroxy-4-[(5 S)-5H-imidazo[4,3-a]isoindol-5-yl]pyrrolidine-1-sulfonamide,

(3S,4S)-3-hydroxy-4-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]pyrrolidine-1-sulfonamide,

(3S,4S)-3-hydroxy-44(5S)-5H-imidazo[4,3-a]isoindol-5-yl]pyrrolidine-1-sulfonamide,

(3R,4S)-4-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3S,4R)-4-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3S,4R)-4-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3R,4S)-4-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(5R,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5S,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5R,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5S,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5R,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5S,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5R,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5S,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(3S,4S)-4-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]oxolan-3-amine,

(3R,4R)-4-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]oxolan-3-amine,

(3R,4R)-4-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]oxolan-3-amine,

(3S,4S)-4-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]oxolan-3-amine,

(3R,4R)-4-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol,

(3S,4S)-3-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

(3S,4S)-4-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol 5-yl)-tetrahydro-2H-pyran-3-ol,

(3S,4S)-4-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol,

(3R,4R)-3-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

(3R,4R)-3-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methylcyclobutan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methylcyclobutan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methylcyclobutan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methylcyclobutan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol 5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(2S,3S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)bicyclo[2.2.2]octan-2-ol,

(2S,3R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)bicyclo[2.2.2]octan-2-ol,

(2R,3R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)bicyclo[2.2.2]octan-2-ol,

(2S,3S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)bicyclo[2.2.2]octan-2-ol,

(2R,3S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)bicyclo[2.2.2]octan-2-ol,

(2R,3R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)bicyclo[2.2.2]octan-2-ol,

(3R,4R)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrothiophene 1,1-dioxide,

(3S,4S)-3-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrothiophene 1,1-dioxide,

(3R,4R)-3-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrothiophene 1,1-dioxide,

(3S,4S)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrothiophene 1,1-dioxide,

(3S,4S)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-sulfonamide,

(3R,4R)-3-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-sulfonamide,

(3R,4R)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-sulfonamide,

(3S,4S)-3-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-sulfonamide,

(3R,4R)-1-(ethylsulfonyl)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)pyrrolidin-3-ol,

(3S,4S)-1-(ethylsulfonyl)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)pyrrolidin-3-ol,

(3R,4R)-1-(ethylsulfonyl)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)pyrrolidin-3-ol,

(3S,4S)-1-(ethylsulfonyl)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)pyrrolidin-3-ol,

tert-butyl (5R,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

tert-butyl (5R,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

tert-butyl (5R,6S)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

tert-butyl (5R,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

tert-butyl (5S,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

tert-butyl (5S,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

tert-butyl (5S,6S)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

tert-butyl (5S,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate,

(R)-4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(S)-4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(R)-3-(5H-imidazo[5,1-a]isoindol-5-yl)thietan-3-ol,

(S)-3-(5H-imidazo[5,1-a]isoindol-5-yl)thietan-3-ol,

(R)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(S)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(R)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(S)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(R)-3-(5H-imidazo[5,1-a]isoindol-5-yl)oxetan-3-ol,

(S)-3-(5H-imidazo[5,1-a]isoindol-5-yl)oxetan-3-ol,

(R)-3,3-difluoro-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(S)-3,3-difluoro-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(R)-4,4-difluoro-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(S)-4,4-difluoro-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(R)-3,3-bis(fluoromethyl)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(S)-3,3-bis(fluoromethyl)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(R)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(S)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol 5-yl)-7-oxaspiro[3.5]nonan-1-ol,

2-((3S,4R)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3R,4S)-4-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3R,4S)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

2-((3S,4R)-4-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile,

(6R,7S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6S,7R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6R,7R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6S,7S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(5R,6S)-5-hydroxy-6((S)-5H-imidazo[5,1-a]isoindol 5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6R)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6S)-5-hydroxy-6((S)-5H-imidazo[5,1-a]isoindol 5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(3S,4R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4-methyltetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4-methyltetrahydro-2H-pyran-4-ol,

(3R,4R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4-methyltetrahydro-2H-pyran-4-ol,

(3R,4S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4-methyltetrahydro-2H-pyran-4-ol,

(5R,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(5R,6S)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(5R,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(5S,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(5S,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(5S,6S)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(5S,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(7S,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol,

(7R,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol,

(7S,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol,

(7R,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol,

(3S,4S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(3R,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(3S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(3R,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(4R,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol,

(4R,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol,

(4S,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol,

(1R,2R)-1-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol,

(1R,2S)-1-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol,

(1S,2S)-1-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol,

(1S,2R)-1-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol,

(1S,2R)-1-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[ 3.3]heptan-2-ol,

(1S,2S)-1-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol,

(1R,2R)-1-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol,

(1R,2S)-1-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol,

(3R,4R)-3-((S)-6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4S)-4-((S)-6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3S,4S)-3-((R)-6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3R,4R)-4-((R)-6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3R,4R)-3-((R)-6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4S)-4-((R)-6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3R,4R)-4-((S)-6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3S,4S)-3-((S)-6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4R)-1-(cyclopropylsulfonyl)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

(3R,4S)-1-(cyclopropylsulfonyl)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

(3S,4R)-1-(cyclopropylsulfonyl)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

(3R,4S)-1-(cyclopropylsulfonyl)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol,

(6S,7R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6R,7S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6S,7S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6R,7R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6R,7R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6S,7S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-01,

(6S,7R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol,

(6R,7S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-01,

(4R,5R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

(4R,5S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

(4S,5S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

(4S,5R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

(4R,5S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

(4R,5R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

(4S,5R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

(4S,5S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol,

(3R,4R)-3-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3R,4R)-3-((R)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((R)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3R,4R)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methylpiperidine-1-sulfonamide,

(3S,4S)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methylpiperidine-1-sulfonamide (31.7 mg, 32%) as a white solid, LCMS (ESI, m/z): 349.2,

(3R,4R)-3-((R)-7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3R,4R)-3-((S)-7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((R)-7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((S)-7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3R,4R)-4-((R)-7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3R,4R)-4-((S)-7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3S,4S)-4-((R)-7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3S,4S)-4-((S)-7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(1S,2R)-8-(ethylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(1R,2S)-8-(ethylsulfonyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(1R,2R)-8-(ethylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(1S,2S)-8-(ethylsulfonyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(1R,2S)-8-(ethylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(3R,4R)-1-(cyclopropylsulfonyl)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

(3S,4S)-1-(cyclopropylsulfonyl)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

(3R,4R)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethylpiperidine-1-sulfonamide,

(3S,4S)-3-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methylpiperidine-1-sulfonamide,

(3S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(3R,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(3S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(isopropylsulfonyl)piperidin-3-ol,

(3R,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(isopropylsulfonyl)piperidin-3-ol,

(3R,4R)-1-(cyclopropylsulfonyl)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

(3S,4S)-1-(cyclopropylsulfonyl)-4((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol,

(3R,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(2,2,2-trifluoroethyl)piperidin-3-ol,

(3S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(2,2,2-trifluoroethyl)piperidin-3-ol,

(3R,4R)-4-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]-1-methylpiperidin-3-ol,

(3S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methylpiperidin-3-ol,

(3S,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2,5,5-tetramethyltetrahydrofuran-3-ol,

(3R,4R)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2,5,5-tetramethyltetrahydrofuran-3-ol,

(3S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2,5,5-tetramethyltetrahydrofuran-3-ol,

(3R,4S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2,5,5-tetramethyltetrahydrofuran-3-ol,

(3S,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2,5,5-tetramethyltetrahydrofuran-3-ol,

(3R,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2,5,5-tetramethyltetrahydrofuran-3-ol,

(3S,4R)-4-((R)-5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

(3S,4R)-4-((S)-5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

(3S,4S)-4-((R)-5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

(3S,4S)-4-((S)-5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

(3R,4R)-4-((R)-5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

(3R,4R)-4-((S)-5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

(3R,4S)-4-((R)-5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

(3R,4S)-4-((S)-5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydrofuran-3-ol,

(3S,4R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol,

(3R,4S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol,

(3S,4S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol,

(3S,4R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol,

(3S,4S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol,

(3R,4R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol,

(3R,4R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol,

(5R,6R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

(5S,6R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

(5S,6S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

(5R,6R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

(5R,6S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

(5S,6S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

(5R,6S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

(5S,6R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol,

(7R,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

(7S,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

(7S,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

(7S,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

(7R,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

(7R,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

(7R,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

(7S,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol,

(3R,4R)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(isopropylsulfonyl)piperidin-3-ol,

(3S,4S)-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(isopropylsulfonyl)piperidin-3-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,6,6-trimethylcyclohexan-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,6,6-trimethylcyclohexan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,6,6-trimethylcyclohexan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,6,6-trimethylcyclohexan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,6,6-trimethylcyclohexan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,6,6-trimethylcyclohexan-1-ol,

(3S,4S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

(3R,4R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

(3R,4S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

(3S,4R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

(3R,4R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

(3S,4S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

(3S,4R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

(3R,4S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)azepan-4-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)azepan-4-ol,

(4R,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)azepan-4-ol,

(4S,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)azepan-4-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol,

(4R,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol,

(4S,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol,

(4S,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol,

(5S,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5R,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5R,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5S,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5R,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5S,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5S,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5R,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(4S,5S)-2-(fluoromethyl)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-2-(fluoromethyl)-5((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(3S,4R)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)thiochromane 1,1-dioxide,

(3S,4S)-4-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)thiochromane 1,1-dioxide,

(5R,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol 5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6R)-5-hydroxy-6((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6S)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6S)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6R)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6R)-5-hydroxy-6((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6S)-5-hydroxy-6((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6R)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6S)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6S)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5R,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(3R,4R)-4-((R)-9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3S,4S)-4-((S)-9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3S,4S)-4-((R)-9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3R,4R)-4-((S)-9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(5R,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(5R,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(5S,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide (5S,6S)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(5S,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(5R,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(5R,6S)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(5S,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(4R,5S)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)azepane-1-sulfonamide,

(4S,5R)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)azepane-1-sulfonamide,

(4R,5S)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)azepane-1-sulfonamide,

(4S,5R)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)azepane-1-sulfonamide,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1R,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1S,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(3S,4S)-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(oxetan-3-yl)piperidin-3-ol,

(5R,6S)-5-hydroxy-6((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

(5R,6R)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

(5S,6R)-5-hydroxy-6((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

(5S,6S)-5-hydroxy-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

(5R,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

(5S,6S)-5-hydroxy-6((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

(5R,6S)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

(5S,6R)-5-hydroxy-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide,

(7S,8R)-8-hydroxy-7((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(7S,8S)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(7R,8S)-8-hydroxy-7((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(7R,8R)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(7R,8R)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(7S,8R)-8-hydroxy-7((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(7S,8S)-8-hydroxy-7((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(7R,8S)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide,

(1R,6R)-2,2-difluoro-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,6S)-2,2-difluoro-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1S,6S)-2,2-difluoro-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(1R,6R)-2,2-difluoro-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol,

(7R,8S)-8-hydroxy-7((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile,

(7S,8S)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile (7S,8R)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile,

(7R,8S)-8-hydroxy-7((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile,

(7R,8R)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile,

(7S,8S)-8-hydroxy-7((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile,

(7S,8R)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile,

(7R,8R)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile,

(S)-3-((5H-imidazo[5,1-a]isoindol-5-yl)methyl)-1-(ethylsulfonyl)azetidin-3-ol,

(R)-3-((5H-imidazo[5,1-a]isoindol-5-yl)methyl)-1-(ethylsulfonyl)azetidin-3-ol,

(1S,2R)-2-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1S,2S)-2-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1R,2S)-2-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1R,2R)-2-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1R,2S)-2-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1R,2R)-2-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1S,2S)-2-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(1S,2R)-2-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol,

(3S,4R)-4-((S)-7-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3R,4S)-4-((R)-7-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3S,4R)-4-((R)-7-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3R,4S)-4-((S)-7-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(5R,6S)-2-amino-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5S,6S)-2-amino-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5R,6R)-2-amino-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5S,6R)-2-amino-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5R,6R)-2-amino-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5S,6R)-2-amino-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5S,6S)-2-amino-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol,

(5S,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

(5R,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

(5S,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

(5R,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

(5R,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

(5S,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

(5R,6S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

(5S,6R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol,

(7R,8R)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol 5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(7R,8R)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(7R,8S)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(7R,8S)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol 5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(7S,8R)-8-hydroxy-7((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(7S,8R)-8-hydroxy-7((S)-5H-imidazo[5,1-a]isoindol 5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(7S,8S)-8-hydroxy-7((R)-5H-imidazo[5,1-a]isoindol 5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile,

(1S,2R)-7-(ethylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-azaspiro[3.5]nonan-1-ol,

(1S,2S)-7-(ethylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol 5-yl)-7-azaspiro[3.5]nonan-1-ol,

(1R,2S)-7-(ethylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-azaspiro[3.5]nonan-1-ol,

(1R,2R)-7-(ethylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-azaspiro[3.5]nonan-1-ol,

(1S,2R)-7-(ethylsulfonyl)-2-((S)-5H-imidazo[5,1-a]isoindol 5-yl)-7-azaspiro[3.5]nonan-1-ol,

(1R,2R)-7-(ethylsulfonyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-azaspiro[3.5]nonan-1-ol,

(1S,2S)-7-(ethylsulfonyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-azaspiro[3.5]nonan-1-ol,

(1R,2S)-7-(ethylsulfonyl)-2-((S)-5H-imidazo[5,1-a]isoindol 5-yl)-7-azaspiro[3.5]nonan-1-ol,

(1R,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol,

(1S,2R)-2-((R)-5H-imidazo[5,1-a]isoindol 5-yl)cycloheptan-1-ol,

(1R,2S)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol,

(1S,2R)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol,

(R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)pyrrolidin-3-ol,

(S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)pyrrolidin-3-ol,

(R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)pyrrolidin-3-ol,

(S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)pyrrolidin-3-ol,

(7S,8S)-7-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(7R,8R)-7-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(3S,4R)-3-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-4-ol,

(3R,4S)-3-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-4-ol,

(3S,4R)-3-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-4-ol,

(3R,4S)-3-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-4-ol,

(3S,4S)-4-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(3R,4R)-4-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(3R,4R)-4-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(3S,4S)-4-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3R,4R)-4-((R)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3S,4S)-4-((R)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(3R,4R)-4-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(5S,6R)-2-amino-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5R,6S)-2-amino-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5R,6R)-2-amino-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5S,6S)-2-amino-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5S,6S)-2-amino-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5R,6R)-2-amino-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5S,6R)-2-amino-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5R,6S)-2-amino-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(7R,8R)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(7R,8R)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(7R,8S)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(7R,8S)-8-hydroxy-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(7S,8R)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(7S,8S)-8-hydroxy-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide,

(5S,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoxalin-5-ol,

(5R,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoxalin-5-ol,

(5S,6S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-5,6,7,8-tetrahydroquinazolin-5-ol,

(5R,6R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-5,6,7,8-tetrahydroquinazolin-5-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-4-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-4-ol,

(7S,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol,

(7R,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol,

tert-Butyl (R)-3-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

tert-Butyl (R)-3-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

tert-Butyl (S)-3-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate,

(R)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol,

(S)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol,

(S)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(R)-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(S)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

(4R,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

(4S,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

(4R,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

(4S,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol,

(R)-1-(5H-imidazo[5,1-a]isoindol-5-yl)-4,4-dimethylcyclohexan-1-ol,

(S)-1-(5H-imidazo[5,1-a]isoindol-5-yl)-4,4-dimethylcyclohexan-1-ol,

(4R,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

(4S,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

(4S,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

(4R,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol,

(R)-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol,

(7S,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol,

(7R,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol,

(7S,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol,

(7R,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol,

(7R,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol,

(7S,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol,

(7R,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridin-4-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridin-4-ol,

(6S,7R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-7-ol,

(6R,7S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-7-ol,

(6S,7R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-7-ol,

(6R,7S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-7-ol,

(1R,4r)-4-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carboxamide,

(1S,4r)-4-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carboxamide,

(1S,4s)-4-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carboxamide,

(1R,4s)-4-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carboxamide,

(R)-8-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(S)-8-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(R)-8-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(S)-8-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol,

(1R,2R)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol,

(S)-3-((R)-5H-Imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(S)-3-((S)-5H-Imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(R)-3-((R)-5H-Imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(R)-3-((S)-5H-Imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol,

(1R,4r)-4-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carbonitrile,

(1R,4s)-4-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carbonitrile,

(1S,4s)-4-hydroxy-4-((R)-5H-imidazo[5,1-a]isoindol 5-yl)cyclohexane-1-carbonitrile,

(1S,4r)-4-hydroxy-4-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carbonitrile,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridin-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridin-4-ol,

(7S,8R)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-ol,

(7R,8S)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-ol,

(7S,8S)-7-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-ol,

(7R,8R)-7-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-ol,

(R)-1-(5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(S)-1-(5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol,

(4R,5R)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol 5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4S,5S)-4-hydroxy-5((R)-5H-imidazo[5,1-a]isoindol 5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4R,5S)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4S,5R)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4R,5R)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4S,5R)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4R,5S)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4S,5S)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(1R,2R)-3,3-bis(fluoromethyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1R,2R)-3,3-bis(fluoromethyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2S)-3,3-bis(fluoromethyl)-2((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2R)-3,3-bis(fluoromethyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1R,2S)-3,3-bis(fluoromethyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(1S,2S)-3,3-bis(fluoromethyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol,

(4R,5R)-3-fluoro-5((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5S)-3-fluoro-5((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-3-fluoro-5((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5S)-3-fluoro-5((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

1-((R)-hydroxy((R)-5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carbonitrile,

1-((S)-hydroxy((R)-5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carbonitrile,

(R)-3-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylpropanamide,

(R)-3-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylpropanamide,

(S)-3-hydroxy-3-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylpropanamide,

(S)-3-hydroxy-3-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylpropanamide,

(4S,5R)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbonitrile,

(4R,5S)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbonitrile,

(4S,5R)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbonitrile,

(4R,5S)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbonitrile,

(4R,5R)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbonitrile,

(4S,5S)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbonitrile,

(6R,7R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

(6S,7S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

(6R,7R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

(6S,7R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

(6R,7S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

(6S,7R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

(6S,7S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

(6R,7S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5R)-3-chloro-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5S)-3-chloro-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5R)-3-chloro-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5S)-3-chloro-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-3-chloro-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5S)-3-chloro-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-2-amino-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5S)-2-amino-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5S)-2-amino-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5R)-2-amino-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5S)-2-amino-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-2-amino-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4S,5R)-2-amino-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4R,5R)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4S,5S)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4S,5S)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4R,5S)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4R,5S)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4S,5R)-4-hydroxy-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4S,5R)-4-hydroxy-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

(4R,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

(4R,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

(4R,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

(4S,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

(4S,5R)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

(4S,5S)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol,

(S)-1-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

(R)-1-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol,

1-((R)-hydroxy((R)-5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carboxamide,

1-((R)-hydroxy((S)-5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carboxamide,

1((S)-hydroxy((R)-5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carboxamide,

1-((S)-hydroxy((S)-5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carboxamide,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol,

(6R,7R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

(6S,7S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

(6R,7S)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

(6S,7R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

(6S,7R)-6-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

(6S,7S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

(6R,7R)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

(6R,7S)-6-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol,

(4S,5S)-5-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]oxazol-4-ol,

(4R,5R)-5-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]oxazol-4-ol,

(5S,6S)-6-((S)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(5R,6R)-6-((R)-8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol,

(3R,4R)-3-((S)-9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((R)-9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3R,4R)-3-((R)-9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4S)-3-((S)-9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol,

(3S,4R)-4-((S)-8-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3R,4S)-4-((R)-8-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3S,4R)-4-((R)-8-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(3R,4S)-4-((S)-8-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol,

(1S,2R)-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-7-methanesulfonyl-7-azaspiro[3.5]nonan-1-ol,

(1R,2S)-2-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]-7-methanesulfonyl-7-azaspiro[3.5]nonan-1-ol,

(1R,2R)-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-7-methanesulfonyl-7-azaspiro[3.5]nonan-1-ol,

(1S,2S)-2-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]-7-methanesulfonyl-7-azaspiro[3.5]nonan-1-ol,

(1R,2S)-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-7-methanesulfonyl-7-azaspiro[3.5]nonan-1-ol,

(1S,2R)-2-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]-7-methanesulfonyl-7-azaspiro[3.5]nonan-1-ol,

(1R,2R)-2-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]-7-methanesulfonyl-7-azaspiro[3.5]nonan-1-ol,

(1S,2S)-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-7-methanesulfonyl-7-azaspiro[3.5]nonan-1-ol,

(1S,2S)-8-(methylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(1R,2R)-8-(methylsulfonyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(1S,2S)-8-(methylsulfonyl)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(1R,2R)-8-(methylsulfonyl)-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol,

(1S,2R)-1-hydroxy-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-7-azaspiro[3.5]nonane-7-sulfonamide,

(1R,2S)-1-hydroxy-2-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]-7-azaspiro[3.5]nonane-7-sulfonamide,

(1R,2R)-1-hydroxy-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-7-azaspiro[3.5]nonane-7-sulfonamide,

(1S,2S)-1-hydroxy-2-((5S)-5H-imidazo[4,3-a]isoindol-5-yl]-7-azaspiro[3.5]nonane-7-sulfonamide,

(1R,2S)-1-hydroxy-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-7-azaspiro[3.5]nonane-7-sulfonamide,

(1S,2R)-1-hydroxy-2-[(5S)-5H-imidazo[4,3-a]isoindol-5-yl]-7-azaspiro[3.5]nonane-7-sulfonamide,

(1R,2R)-1-hydroxy-2-[(5 S)-5H-imidazo[4,3-a]isoindol-5-yl]-7-azaspiro[3.5]nonane-7-sulfonamide,

(1S,2S)-1-hydroxy-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-7-azaspiro[3.5]nonane-7-sulfonamide,

(1S,2S)-1-hydroxy-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-8-azaspiro[4.5]decane-8-sulfonamide,

(1R,2R)-1-hydroxy-2-[(5 S)-5H-imidazo[4,3-a]isoindol-5-yl]-8-azaspiro[4.5]decane-8-sulfonamide,

(1S,2S)-1-hydroxy-2-((5S)-5H-imidazo[4,3-a]isoindol-5-yl]-8-azaspiro[4.5]decane-8-sulfonamide, or

(1R,2R)-1-hydroxy-2-[(5R)-5H-imidazo[4,3-a]isoindol-5-yl]-8-azaspiro[4.5]decane-8-sulfonamide;

or a pharmaceutically acceptable salt thereof.

11. The compound of claim 1 , wherein ring A is C 3-10 cycloalkyl.

12. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable diluent, excipient, or carrier.

13. The pharmaceutical composition according to claim 12 , further comprising a second therapeutic agent.

14. A pharmaceutical composition comprising a compound according to claim 2 and a pharmaceutically acceptable diluent, excipient, or carrier.

15. A kit comprising compound according to claim 1 and a second therapeutic agent.

16. A method for treating tryptophan 2,3-dioxygenase (TDO2) mediated immunosuppression associated with a disease in a subject in need thereof, comprising administering an effective tryptophan 2,3-dioxygenase inhibiting amount of a compound according to claim 1 .

17. The method of claim 16 , wherein the administration is conducted simultaneously or serially with a second therapeutic treatment.

Assignments (4)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2018

From: LIN, XINGYU; YUEN, PO-WAI

To: PHARMARON BEIJING CO. LTD.

Reel/Frame 047456/0224 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2018

From: JAIPURI, FIROZ; KUMAR, SANJEEV; LI, XIAOKAI; PAVANNA, ROHEETH; POTTURI, HIMA; VELVADAPU, VENKATA; WALDO, JESSE; ZHANG, ZUHUI

To: NEWLINK GENETICS CORPORATION

Reel/Frame 047456/0244 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2018

From: PHARMARON BEIJING CO., LTD.

To: PHARMARON, INC.

Reel/Frame 047456/0272 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2018

From: PHARMARON, INC.

To: GENENTECH, INC.

Reel/Frame 047456/0304 →

Priority Claims (3)

WO PCT/CN2015/098685 · Dec 24, 2015 · international

WO PCT/CN2016/103358 · Oct 26, 2016 · international

WO PCT/CN2016/106624 · Nov 21, 2016 · international

Continuity (1)

Related Publication 20190016726A1 · Jan 17, 2019

Cited By (1)

US 12,583,858