Treatments and prevention of opioid neonatal abstinence syndrome
Disclosed is a method for reducing or preventing fetal opioid dependence in a drug dependent or opioid tolerant pregnant subject. The method involves administering to the pregnant subject a composition comprising an opioid antagonist in an amount effective to reduce or prevent fetal opioid dependence, wherein the opioid antagonist a) is orally available or delivered systemically and reaches the circulation of the pregnant subject, b) is substantially excluded from the subject's brain by the blood brain barrier, and c) penetrates the placenta and enters the fetal brain. The method also includes administering the opioid antagonist to the neonate in increasing amounts to facilitate weaning the neonate from continued opioid maintenance.
1. A method for reducing or preventing opioid dependence of a fetus carried by a drug dependent or opioid tolerant pregnant subject receiving opioid therapy or maintenance, comprising administering to the pregnant subject receiving opioid therapy or maintenance a composition comprising an opioid antagonist in an amount effective for reducing or preventing opioid dependence of the fetus, wherein the opioid antagonist is a neutral antagonist to μ-opioid receptor.
2. The method of claim 1 , wherein the opioid antagonist comprises 6β-naltrexol.
3. The method of claim 1 , wherein the opioid antagonist is delivered in two daily subdoses.
4. The method of claim 1 , wherein the opioid antagonist is delivered in a daily dosage range from about 0.1 mg to about 100 mg.
5. The method of claim 1 , wherein the composition comprises a sustained drug release formulation.
6. The method of claim 1 , wherein the opioid antagonist is orally available.