Aryl substituted pyrimidines for use in influenza virus infection
The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
1. A compound having the structural formula
a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof.
2. A pharmaceutical composition comprising the compound according to claim 1 , stereo-isomeric form, pharmaceutically acceptable salt, solvate or polymorph thereof, and one or more pharmaceutically acceptable excipients, diluents or carriers.
3. A method of treating viral influenza infection in a patient, said method comprising administering to the patient in need thereof an effective amount of a compound having the structural formula
a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof.
4. The method of claim 3 , wherein the compound, stereio-isomeric form, pharmaceutically acceptable salt, solvate or polymorph thereof, is administered as a pharmaceutical composition comprising one or more pharmaceutically acceptable excipients, diluents, or carriers.
5. The method of claim 3 , further comprising co-administering to said patient an additional therapeutic agent.
6. The method of claim 5 , wherein the additional therapeutic agent is selected from an antiviral agent or influenza vaccine, or both.
7. The method of claim 6 , wherein the additional therapeutic agent is an antiviral agent.
8. A method of inhibiting replication of influenza virus(es) in a biological sample, said method comprising administering to the biological sample a compound having the structural formula
a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof.