Solid preparation, method for producing solid reparation, and method for generating hydrogen
One solid preparation of the present invention mainly includes silicon fine particles, and has a capability of generating hydrogen. In addition, one specific example of the solid preparation mainly includes silicon fine particles having a crystallite diameter principally of 1 nm or more and 100 nm or less, and exhibits a capability of generating hydrogen in an amount of 3 ml/g or more when brought into contact with a water-containing liquid having a pH value of 7 or more. In this solid preparation, hydrogen is generated when the silicon fine particles are brought into contact with a water-containing liquid having a pH value of 7 or more. Therefore, taking advantage of the characteristics of the solid preparation, generation of hydrogen is promoted in, for example, a gastrointestinal tract where the pH value is 7 or more due to secretion of pancreatic fluid after passage through the stomach after oral ingestion.
1. A solid preparation comprising silicon fine particles and the following (a) or (b):
(a) an organic acid;
(b) a covering layer which is not dissolved in a stomach and is dissolved in a small intestine and/or a large intestine, and
the solid preparation has a capability of generating hydrogen.
2. A solid preparation which comprises silicon fine particles having a crystallite diameter of 1 nm or more and 100 nm or less, and exhibits a capability of generating hydrogen in an amount of 3 ml/g or more when brought into contact with a water-containing liquid having a pH value of 7 or more.
3. The solid preparation according to claim 2 , further comprising a pH value adjusting agent which causes the water-containing liquid to have a pH value of more than 7.4.
4. The solid preparation according to claim 3 , wherein the pH value adjusting agent is sodium hydrogencarbonate.
5. The solid preparation according to claim 1 , which is a capsule preparation in which the silicon fine particles are encapsulated, or a tablet formed so that the silicon fine particles are in a lump form.
6. A method for producing a solid preparation, the method comprising the step of finely dividing silicon particles having a crystal grain diameter of more than 1 μm by a physical grinding method, so that the silicon particles are formed into silicon fine particles,
the solid preparation comprising silicon fine particles and the following (a) or (b):
(a) an organic acid;
(b) a covering layer which is not dissolved in a stomach and is dissolved in a small intestine and/or a large intestine, and
the solid preparation has a capability of generating hydrogen.
7. The method for producing a solid preparation according to claim 6 , wherein the physical grinding method is selected from a bead mill grinding method, a planetary ball mill grinding method, a jet mill grinding method, and a combination thereof.
8. A method for generating hydrogen, the method comprising:
a first contact step of bringing a solid preparation, having a capability of generating hydrogen, which comprises silicon fine particles and the following (a) or (b):
(a) an organic acid;
(b) a covering layer which is not dissolved in a stomach and is dissolved in a small intestine and/or a large intestine,
into contact with a first water-containing liquid having a pH of less than 7; and
a second contact step of bringing the fine silicon particles into contact with a second water-containing liquid having a pH value of 7 or more after the first contact step.
9. The method for generating hydrogen according to claim 8 , wherein the solid preparation is brought into contact with the second water-containing liquid at 35° C. or higher and 45° C. or lower.
10. The method for generating hydrogen according to claim 8 , wherein the solid preparation is brought into contact with the second water-containing liquid having a pH value of 8 or more.
11. The method for generating hydrogen according to claim 8 , wherein the solid preparation is one selected from the group consisting of a capsule preparation in which the silicon fine particles are encapsulated, and a tablet formed so that the silicon fine particles are in a lump form.
12. The method for generating hydrogen according to claim 8 , the method further comprising the step of causing a rearing animal to ingest the solid preparation,
the solid preparation being disintegrated in gastrointestinal tracts of the rearing animal.