Methods of treatment using anti-c-met antibodies
The present disclosure provides a pharmaceutical composition for preventing or treating a variety of diseases through c-Met activation in cells induced by the anti-c-Met antibody described herein which functions as a c-Met agonist. The current invention concerns a method for preventing or treating various diseases through c-Met activation by the anti-c-Met antibody described herein.
1. A method for treating a disease selected from the group consisting of ischemic disorder, stroke, kidney injury or disease, retinal neovascularization disorder, amyotrophic lateral sclerosis, and wound healing, the method comprising administering to a subject in need thereof a therapeutically effective amount of a polypeptide or a pharmaceutical composition comprising the polypeptide, wherein the polypeptide comprises an immunoglobulin heavy chain variable domain which comprises a CDR1 of SEQ ID NO:5, a CDR2 of SEQ ID NO:6, a CDR3 of SEQ ID NO:7, and a light chain variable domain which comprises a CDR1 of SEQ ID NO:8, a CDR2 of SEQ ID NO:9, and a CDR3 of SEQ ID NO:10.
2. The method according to claim 1 , wherein the ischemic disorder is selected from the group consisting of ischemia of brain tissue, heart tissue, kidney tissue, or intestinal tissue.
3. The method according to claim 1 , wherein the stroke is an embolic stroke or a thrombotic stroke.
4. The method according to claim 1 , wherein the kidney injury or disease is a fibrotic condition.
5. The method according to claim 1 , wherein the kidney injury or disease is selected from the group consisting of renal fibrosis, chronic kidney fibrosis, chronic nephropathy associated with diabetes, lupus, scleroderma of the kidney, glomerular nephritis, focal segmental glomerular sclerosis, IgA nephropathyrenal fibrosis associated with human chronic kidney disease (CD), chronic progressive nephropathy (CPN), tubulointerstitial fibrosis, ureteral obstruction, chronic uremia, chronic interstitial nephritis, radiation nephropathy, glomerulosclerosis, progressive glomerulonephrosis (PGN), endothelial/thrombotic microangiopathy injury, HIV-associated nephropathy, and a fibrosis associated with exposure to a toxin, an irritant, or a chemotherapeutic agent.
6. The method according to claim 1 , wherein the retinal neovascularization disorder is caused by a member selected from the group consisting of macular degeneration, histoplasmosis, pathological myopia, angioid streaks, anterior ischemic optic neuropathy, bacterial endocarditis, Best's disease, birdshot retinochoroidopathy, choroidal hemangioma, choroidal nevi, choroidal nonperfusion, choroidal osteomas, choroidal rupture, choroideremia, chronic retinal detachment, coloboma of the retina, Drusen, endogenous Candida endophthalmitis , extrapapillary hamartomas of the retinal pigmented epithelium, fundus flavimaculatus, idiopathic, macular hole, malignant melanoma, membranoproliferative glomerulonephritis (type II), metallic intraocular foreign body, morning glory disc syndrome, multiple evanescent white-dot syndrome (MEWDS), neovascularization at or a serrata, operating microscope burn, optic nerve head pits, photocoagulation, punctuate inner choroidopathy, rubella, sarcoidosis, serpiginous or geographic choroiditis, subretinal fluid drainage, tilted disc syndrome, Taxoplasma retinochoroiditis, tuberculosis, Vogt-Koyanagi-Harada syndrome, diabetic retinopathy, non-diabetic retinopathy, branch vein occlusion, central retinal vein occlusion, retinopathy in premature infants, rubeosis iridis, neovascular glaucoma, periofoveal telangiectasis, sickle cell retinopathy, Eales disease, retinal vasculitis, Von Hippel Linau disease, radiation retinopathy, retinal cryoinjury, retinitis pigmentosa, retinochoroidal coloboma, corneal neovascularization due to herpes simplex keratitis, corneal ulcers, keratoplasty, pterigyia, and trauma.
7. The method according to claim 1 , wherein the retinal neovascularization disorder is choroidal neovascularization.
8. The method according to claim 1 , wherein the wound is a mechanical, chemical, bacterial, or thermal wound.
9. The method according to claim 1 , wherein the wound is selected from the group consisting of an incision, a laceration, an abrasion, a puncture wound, a penetration wound, and a gunshot wound.
10. The method according to claim 1 , wherein the wound is a skin wound.
11. The method according to claim 1 , wherein the heavy chain variable domain comprises SEQ ID NO:1 and the light chain variable domain comprises SEQ ID NO:2.
12. The method according to claim 1 wherein the polypeptide is an antibody or fragment thereof.
13. The method according to claim 12 , wherein the antibody or fragment thereof is a chimeric antibody, a humanized antibody, or a human antibody.
14. The method according to claim 1 , wherein the polypeptide comprises a scFv.
15. The method according to claim 14 , wherein the heavy chain variable domain comprises SEQ ID NO:1 and the light chain variable domain comprises SEQ ID NO:2.
16. The method according to claim 14 , wherein the scFv comprises SEQ ID NO:3.
17. The method according to claim 1 , wherein the administering is intravenous, intravitreal, intrathecal, parenteral, subcutaneous, topical, transdermal or by infusion.
18. The method according to claim 1 , wherein the subject is not suffering from a cancer.