IP Library › Granted Patent US 10,968,255
Granted Patent B2
US 10,968,255 · App. 16/081,581 · Granted Apr 6, 2021

Compositions comprising HIV envelopes to induce CH235 lineage antibodies

Inventors: Barton F. Haynes (Durham, NC); Mattia Bonsignori (Durham, NC); Hua-Xin Liao (Durham, NC); Bette T. Korber (Los Alamos, NM); Peter T. Hraber (Los Alamos, NM); Kevin Saunders (Durham, NC)
Assignees: Duke University; Triad National Security, LLC
C07K14/005A61K39/21A61K39/39A61K45/06C12N7/00A61K2039/545C12N2740/16122C12N2740/16134
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Quick Facts
Patent No.
US 10,968,255
App. No.
16/081,581
Granted
Apr 6, 2021
Kind
B2
Abstract

In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Claims (16)

1. A recombinant HIV-1 envelope polypeptide comprising all the consecutive amino acids after the signal peptide in HIV-1 envelope CH505TFchim.6R.SOSIP.664v4.1 (SEQ ID NO:260), CH505M5chim.6R.SOSIP.664v4.1 (SEQ ID NO:242), CH505M11chim.6R.SOSIP.664v4.1 (SEQ ID NO:244), CH505w20.14chim.6R.SOSIP.664v4.1 (SEQ ID NO:254), CH505w30.20.chim.6R.SOSIP.664v4.1 (SEQ ID NO:258), CH505w30.12chim.6R.SOSIP.664v4.1 (SEQ ID NO:256), or CH505w136.B18chim.6R.SOSIP.664v4.1 (SEQ ID NO:252).

2. A recombinant trimer comprising three identical polypeptides of claim 1 .

3. An immunogenic composition comprising the recombinant trimer of claim 2 and a carrier.

4. The composition of claim 3 further comprising an adjuvant.

5. The recombinant trimer of claim 2 comprising three polypeptides, each polypeptide comprising all the consecutive amino acids after the signal peptide in HIV-1 envelope CH505TFchim.6R.SOSIP644v4.1 (SEQ ID NO:260).

6. An immunogenic composition comprising the recombinant trimer of claim 5 and a carrier.

7. The immunogenic composition of claim 6 further comprising an adjuvant.

8. The recombinant trimer of claim 5 , wherein the trimer is comprised in a nanoparticle.

9. The recombinant trimer of claim 2 , wherein the trimer is comprised in a nanoparticle.

10. A method of inducing an immune response in a subject comprising administering a composition comprising a recombinant HIV-1 envelope polypeptide comprising all the consecutive amino acids after the signal peptide in HIV-1 envelope CH505TFchim.6R.SOSIP.664v4.1 (SEQ ID NO:260), CH505M5chim.6R.SOSIP.664v4.1 (SEQ ID NO:242), CH505M11chim.6R.SOSIP.664v4.1 (SEQ ID NO:244), CH505w20.14chim.6R.SOSIP.664v4.1 (SEQ ID NO:254), CH505w30.20.chim.6R.SOSIP.664v4.1 (SEQ ID NO:258), CH505w30.12chim.6R.SOSIP.664v4.1 (SEQ ID NO:256), or CH505w136.B18chim.6R.SOSIP.664v4.1 (SEQ ID NO:252).

11. The method of 10 , wherein the composition comprises a recombinant trimer comprising three identical polypeptides of claim 10 .

12. The method of claim 11 , comprising administering HIV-1 polypeptides CH505TFchim.6R.SOSIP.664v4.1 (SEQ ID NO:260) as the recombinant trimer.

13. The method of claim 12 , wherein the CH505TFchim.6R.SOSIP.664v4.1 (SEQ ID NO:260) recombinant trimer is administered as a nanoparticle.

14. The method of claim 10 , wherein the composition further comprises a carrier.

15. The method of claim 14 , further comprising administering an adjuvant.

16. The method of claim 10 , further comprising administering a nucleic acid encoding CH5050TFchim.6R.SOSIP.664v4.1 (SEQ ID NO:260).

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2020
From: LOS ALAMOS NATIONAL SECURITY, LLC
To: TRIAD NATIONAL SECURITY, LLC
Reel/Frame 053565/0774 →
CONFIRMATORY LICENSE Recorded Jun 15, 2020
From: TRIAD NATIONAL SECURITY, LLC
To: U.S. DEPARTMENT OF ENERGY
Reel/Frame 052937/0228 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 3, 2019
From: HAYNES, BARTON F.; BONSIGNORI, MATTIA; LIAO, HUA-XIN; SAUNDERS, KEVIN
To: DUKE UNIVERSITY
Reel/Frame 048777/0688 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 3, 2019
From: KORBER, BETTE T.; HRABER, PETER T.
To: LOS ALAMOS NATIONAL SECURITY, LLC
Reel/Frame 048777/0822 →
Continuity (3)
Provisional Application 62403503 · Oct 3, 2016
Provisional Application 62302017 · Mar 1, 2016
Related Publication 20200002383A1 · Jan 2, 2020