Prevention, treatment and reversal of disease using therapeutically effective amounts of dicarboxylic acid compounds
View Patent ↗Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include dicarboxylic acid compounds containing electron withdrawing groups, alkyl esters of dicarboxylic acids containing electron withdrawing groups, or compounds of Formulae I to X. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
1. A compound comprising a dicarboxylic acid having the structure:
wherein X is acyl, carboxylic acid, an ester, a halogen, fluoromethyl, —CN, sulfonyl, sulfone, sulfonic acid, primary ammonium, secondary ammonium, tertiary ammonium, or −NO 2 ,
m is from 1 to 10; and
n is from 1 to 10.
2. A compound comprising a dicarboxylic acid having the structure:
wherein X is acyl, carboxylic acid, an ester, a halogen, fluoromethyl, —CN, sulfonyl, sulfone, sulfonic acid, primary ammonium, secondary ammonium, tertiary ammonium, or —NO 2 ;
Y and Z are each, independently, hydrogen or a C 1 to C 10 alkyl;
m is from 1 to 10; and
n is from 1 to 10.
3. A compound comprising a dicarboxylic acid having the structure:
wherein X is an electron withdrawing group;
Y and Z are each, independently, hydrogen or C 1 to C 10 alkyl;
p and t are each, independently, 1 to 10;
s is absent or 1 to 10, and
r is 1.
4. A pharmaceutical composition comprising a therapeutically effective amount of a compound selected from a compound of Formulae III, VII or IX, and a pharmaceutically acceptable excipient, wherein Formulae III, VII or IX are:
wherein X is an electron withdrawing group,
m is from 1 to 10; and
n is from 1 to 10;
wherein X is an electron withdrawing group;
Y and Z are each, independently, hydrogen or a C 1 to C 10 alkyl;
m is from 1 to 10; and
n is from 1 to 10;
wherein X is an electron withdrawing group;
Y and Z are each, independently, hydrogen or C 1 to C 10 alkyl;
p and t are each, independently, 1 to 10;
s is absent or 1 to 10, and
r is 1 to 5.
5. The composition of claim 4 , wherein said therapeutically effective amount is from about 25 milligrams to less than 450 milligrams.
6. The composition of claim 4 , wherein said therapeutically effective amount is from about 100 milligrams to about 300 milligrams.
7. The composition of claim 4 , wherein said therapeutically effective amount is from about 100 milligrams to about 200 milligrams.
8. The composition of claim 4 , wherein said therapeutically effective amount is about 150 milligrams.
9. The compound of claim 1 , wherein X is NO 2 .
10. The compound of claim 2 , wherein X is NO 2 .
11. The compound of claim 3 , wherein X is NO 2 .
12. The compound of claim 1 , wherein m is 2 and n is 1.
13. The compound of claim 2 , wherein m is 2 and n is 1.
14. The compound of claim 2 , wherein Y is a C 1 -C 3 alkyl and Z is a C 1 -C 3 alkyl.
15. The compound of claim 10 , wherein Y is a C 1 -C 3 alkyl and Z is a C 1 -C 3 alkyl.
16. The compound of claim 2 , wherein Y is ethyl or methyl and Z is ethyl or methyl.
17. The compound of claim 10 , wherein Y is ethyl or methyl and Z is ethyl or methyl.
18. The compound of claim 1 , wherein X is CN.
19. The compound of claim 2 , wherein X is CN.
20. The compound of claim 3 , wherein X is CN.
21. The compound of claim 1 , wherein X is Cl, Br or F.
22. The compound of claim 1 , wherein X is Cl, Br or F.
23. The compound of claim 3 , wherein X is Cl, Br or F.
24. The compound of claim 12 , wherein X is NO 2 .
25. The composition of claim 4 , wherein X is NO 2 in Formulae III, VII or IX.
26. The composition of claim 4 , wherein X is CN in Formulae III, VII or IX.
27. The composition of claim 4 , wherein X is Cl, Br or F in Formulae III, VII or IX.
28. The composition of claim 4 , wherein m is 2 and n is 1 in Formulae III or VII.
29. The composition of claim 4 , wherein Y is a C 1 -C 3 alkyl and Z is a C 1 -C 3 alkyl in Formulae VII or IX.
30. The composition of claim 4 , wherein Y is ethyl or methyl and Z is ethyl or methyl in Formulae VII or IX.
31. The composition of claim 4 , wherein the compound is a compound of Formulae III.
32. The composition of claim 4 , wherein the compound is a compound of Formulae VII.
33. The composition of claim 4 , wherein the compound is a compound of Formulae IX.
34. The composition of claim 4 , wherein X is acyl, carboxylic acid, an ester, a halogen, fluoromethyl, —CN, sulfonyl, sulfone, sulfonic acid, primary ammonium, secondary ammonium, tertiary ammonium, or —NO 2 in Formulae III, VII or IX.
35. The composition of claim 25 , wherein the compound is a compound of Formulae III.
36. The composition of claim 25 , wherein the compound is a compound of Formulae VII.
37. The composition of claim 25 , wherein the compound is a compound of Formulae IX.