Compositions and methods for treating cancers
Compositions and methods for treating solid and hematological cancers, including Acute Myeloid Leukemia (AML), are provided herein. The methods include administering truncated, dominant-negative, forms of Galectin-3.
1. A truncated galectin-3 (Gal-3) protein consisting of the amino acid sequence of SEQ ID NO:7.
2. A pharmaceutical composition, comprising the protein of claim 1 ; and a pharmaceutically acceptable excipient.
3. The pharmaceutical composition of claim 2 , further comprising a second therapeutic agent, wherein the second therapeutic is a chemotherapeutic agent.
4. A polynucleotide encoding the protein of claim 1 , wherein the polynucleotide comprises the sequence of SEQ. ID NO: 8.
5. A nucleic acid vector, the vector comprising the polynucleotide of claim 4 .