IP Library › Granted Patent US 11,155,531
Granted Patent B2
US 11,155,531 · App. 16/083,924 · Granted Oct 26, 2021

N-lipoic-amino acid or peptide, derivatives and their uses

Inventors: Ruey J. Yu (Chalfont, PA); Eugene J. Vanscott (Abington, PA)
Assignee: Neostrata Company, Inc.
C07D339/04A61K8/44A61K8/4986A61K8/64A61K9/0014A61K45/06A61K47/64A61Q19/02A61Q19/08C07K5/06C07K5/06121C07K5/06165C07K5/08A61K38/00
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Quick Facts
Patent No.
US 11,155,531
App. No.
16/083,924
Granted
Oct 26, 2021
Kind
B2
Abstract

Novel compounds of N-Lipoic-amino acid, N-Lipoic-peptides and their derivatives are described. Also described are compositions and method of compositions containing the derivatives of the amino acids or peptides, and their uses including treating and preventing dermatological or cosmetic conditions or other disorders of the cutaneous system. Compositions and methods of using the compositions for skin lightening and cosmetics are also disclosed.

Claims (4)

1. A method of treating a cosmetic condition or dermatological disorder selected from the group consisting of fine lines, wrinkles, age spots, and for skin lightening comprising topically administering to a subject a composition comprising therapeutically effective amount of a compound selected from the group consisting of: N-Lp-Cys-NH 2 ; N-Lp-Tyr-NH 2 ; N-Lp-Tyr(OAc)-NH 2 ; N-Lp-Pro-NH 2 ; N-Lp-Cys-OEt; N-Lp-Cys-(SAc)-OEt; N-Lp-Cys-(SAc)-NH 2 ; N-Lp-Gly-Cys-NH 2 ; N-Lp-Pro-Cys-NH 2 ; N-Lp-Cys-Gy-NH 2 ; N-Lp-Tyr-Gy-NH 2 ; N-Lp-Gly-Tyr-NH 2 ; N-Lp-Tyr-Cys-NH 2 ; N-Lp-Tyr-Cys-OEt; N-Lp-Gly-Cys-OEt; N-Lp-Gly-Cys-Cys-NH 2 ; N-Lp-Cys-Cys-Cys-NH 2 ; N-Lp-Tyr-Cys-Cys-NH 2 ; N-Lp-Gly-Tyr-Cys-NH 2 ; and N-Lp-Pro-Cys-Cys-NH 2 .

2. The method of claim 1 , wherein the compound is selected from the group consisting of: N-Lp-Cys-NH 2 ; N-Lp-Tyr-NH 2 ; N-Lp-Tyr(OAc)-NH 2 ; N-Lp-Pro-NH 2 ; N-Lp-Cys-OEt; N-Lp-Cys-(SAc)-OEt; and N-Lp-Cys-(SAc)-NH 2 .

3. The method of claim 1 , wherein the compound is a lipoic dipeptide selected from the group consisting of: N-Lp-Gly-Cys-NH 2 ; N-Lp-Pro-Cys-NH 2 ; N-Lp-Cys-Gly-NH 2 ; N-Lp-Tyr-Gly-NH 2 ; N-Lp-Gly-Tyr-NH 2 ; N-Lp-Tyr-Cys-NH 2 ; N-Lp-Tyr-Cys-OEt; and N-Lp-Gly-Cys-OEt.

4. The method of claim 1 , wherein the compound is a lipoic tripeptide selected from the group consisting of: N-Lp-Gly-Cys-Cys-NH 2 ; N-Lp-Cys-Cys-Cys-NH 2 ; N-Lp-Tyr-Cys-Cys-NH 2 ; N-Lp-Gly-Tyr-Cys-NH 2 ; and N-Lp-Pro-Cys-Cys-NH 2 .

Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE CORRECT APPLICATION NUMBER PREVIOUSLY RECORDED AT REEL: 047386 FRAME: 0018. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Mar 12, 2019
From: VANSCOTT, EUGENE J.; YU, RUEY J.
To: NEOSTRATA COMPANY, INC.
Reel/Frame 048571/0385 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 1, 2018
From: VANSCOTT, EUGENE J.; YU, RUEY J.
To: NEOSTRATA COMPANY, INC.
Reel/Frame 047386/0018 →
Continuity (1)
Related Publication 20190161467A1 · May 30, 2019
Cited By (1)
US 12,435,056