Analgesic compounds
Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.
1. A method for reducing or at least partially preventing pain or fever comprising administering an effective amount of a medicament comprising any of the compound selected from the group consisting of:
or
a pharmaceutically acceptable salt of any of the foregoing.
2. The method of claim 1 , further comprising administering an opioid analgesic in combination.
3. The method of claim 2 , wherein the opioid analgesic is selected from the group consisting of morphine, codeine, hydrocodone, oxycodone, fentanyl, pethidine, methadone, pentazocine, sufentanil, levorphanol, dihydrocodeine, nalbuphine, butorphanol, tramadol, meptazinol, buprenorphine, dipipanone, alfentanil, remifentanil, oxymorphone, tapentadol, propoxyphene and hydromorphone.
4. The method of claim 1 , wherein the compound is administered intravenously, administered orally or administered intraperitoneally.
5. The method of claim 1 , wherein the pain is acute pain.
6. The method of claim 1 , wherein the pain is post-operative pain.
7. The method of claim 1 , wherein the pain is chronic pain.
8. The method of claim 1 , wherein the pain is nociceptive pain.
9. The method of claim 1 , wherein the pain is selected from the group consisting of osteoarthritis pain, rheumatoid arthritis pain, migraine pain, lower back pain, cancer pain and fibromyalgia pain.
10. The method of claim 1 , wherein the pain is neuropathic pain.
11. The method of claim 1 , wherein the pain is visceral pain.
12. The method of claim 1 , wherein the pain is mixed pain.