Conjugate of finasteride with peptide
A composition for preventing hair loss and, more specifically, to a compound having a structure in which finasteride and a peptide are linked through a covalent bond and a pharmaceutical composition or a cosmetic composition for preventing hair loss or promoting hair growth comprising the same. The compound having a structure in which finasteride and a peptide are linked through a covalent bond is excellent in physiological activities such as hair loss improvement, hair growth promotion, cell growth promotion, etc., is excellent in stability in water and skin permeation, and thus can be effectively used as a composition for preventing hair loss and promoting hair growth.
1. A compound having a finasteride moiety represented by
the following structure:
wherein the peptide is selected from the croup consisting of SEQ ID NOs: 1-3, wherein the peptide is water soluble peptide, and wherein the water soluble peptide of the compound increases the water solubility of the finasteride moiety.
2. A pharmaceutical composition for reducing hair loss or promoting hair growth comprising the compound of claim 1 .
3. A cosmetic composition for reducing hair loss or promoting hair growth comprising the compound of claim 1 .
4. The cosmetic composition of claim 3 , which has a formulation selected from the group consisting of skin lotion, milk lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray, powder, hair tonic, hear cream, lair lotion, hair shampoo, hair rinse, hair conditioner, hair spray, hair aerosol, pomade, solgel, emulsion, oil, wax and aerosol.