Purine inhibitors of human phosphatidylinositol 3-kinase delta

1. A compound of formula I or a pharmaceutically acceptable salt or stereoisomer thereof:

wherein

is selected from the group consisting of

R 1 is selected from the group consisting of hydrogen, a 5- to 6-membered heteroaryl, C 1-6 alkyl, and C 1-6 haloalkyl, wherein said heteroaryl and alkyl is substituted with 0, 1, 2, or 3 moieties each independently selected from the group consisting of C 1-6 alkyl, halogen, and OH;

R 2 is hydrogen or C 1-6 alkyl;

R 3 is selected the group consisting of from hydrogen, C 1-6 alkyl, and cyano;

R 4 is selected from the group consisting of

hydrogen,

cyano,

C 1-6 alkyl,

C 1-6 heteroalkyl,

C 3-12 heterocycloalkylC 0-6 alkyl,

C 3-12 cycloalkylC 0-6 alkyl,

arylC 0-6 alkyl,

heteroarylC 0-6 alkyl,

spirocyclylC 0-6 alkyl,

C 3-12 cycloalkylC 0-10 alkyloxy,

amino,

-amino(C 1-10 alkyl) 1-2 ,

C 3-12 cycloalkylC 0-10 alkylamino,

heteroarylC 0-10 alkylamino,

C 3-12 heterocycloalkylC 0-10 alkylamino,

arylC 0-10 alkylamino,

hydroxy,

—(C 1-10 alkyl)OH, and

C 1-10 alkoxy;

wherein R 4 is substituted with 0, 1, 2, or 3 groups selected from the group consisting of C 1-6 alkyl, cyano, halogen, hydroxy, —O—C 1-6 alkyl, and —(C 1-10 alkyl)OH;

further wherein, optionally, R 3 and R 4 along with the carbon to which they are attached may join together to form a 4 to 6 membered saturated ring system substituted with 0, 1, or 2 moieties selected from the group consisting of C 1-6 alkyl, halogen, hydroxy, —O—C 1-6 alkyl, —(C 1-10 alkyl)OH, —SO 2 C 1-6 alkyl, —SO 2 CF 3 , —SO 2 CF 2 H, and C 3-12 cycloalkylC 0-10 alkylcarbonyl;

R 5 is selected from the group consisting of

hydrogen,

C 1-6 alkyl,

C 1-10 alkylcarbonyl,

C 3-12 cycloalkylC 0-10 alkyl,

C 3-12 heterocycloalkylC 0-10 alkyl,

arylC 0-10 alkyl, and

—(C 1-10 alkyl)OH; and

R 6 is hydrogen, oxo (═O), or C 1-3 alkyl.

2. The compound according to claim 1 , wherein R 1 is selected from the group consisting of hydrogen, difluoromethyl, pyrimidinyl, pyrazolyl wherein said pyrimidinyl and said pyrazolyl are each substituted with 0, 1, 2, or 3 moieties each independently selected from the group consisting of C 1-6 alkyl, halogen and OH.

3. The compound according to claim 2 , wherein R 2 is selected from the group consisting of hydrogen and C 1-6 alkyl.

4. The compound according to claim 3 , wherein R 2 is selected from the group consisting of methyl, ethyl, and hydrogen.

5. The compound according to claim 3 , wherein R 2 is hydrogen.

6. The compound according to claim 1 , wherein R 3 is selected from the group consisting of hydrogen, C 1-6 alkyl, and cyano.

7. The compound according to claim 6 , wherein R 3 is selected from the group consisting of hydrogen, methyl, and cyano.

8. The compound according to claim 1 , wherein R 4 is selected from the group consisting of

hydrogen,

cyano,

C 1-6 alkyl,

C 3-12 heterocycloalkylC 0-6 alkyl,

C 3-12 cycloalkylC 0-6 alkyl,

arylC 0-6 alkyl,

heteroarylC 0-6 alkyl,

spirocyclylC 0-6 alkyl,

C 3-12 cycloalkylC 0-10 alkyloxy,

-amino(C 1-10 alkyl) 1-2 ,

C 3-12 cycloalkylC 0-10 alkylamino,

heteroarylC 0-10 alkylamino,

C 3-12 heterocycloalkylC 0-10 alkylamino, and

—(C 1-10 alkyl)OH;

wherein said aryl is a 6-membered aryl and said heteroaryl is a 5- to 6-membered heteroaryl and further wherein R 4 is substituted with 0, 1, 2, or 3 groups selected from the group consisting of C 1-6 alkyl, cyano, halogen, hydroxy, and methoxy.

9. The compound according to claim 6 , wherein R 4 is selected from the group consisting of 2-methylpropyl, oxetanylmethyl, oxetan-3-ylmethyl, cyclopropylmethyl, benzyl, methylpyrimidinyl, methylpyrimidin-5-yl, tetrahydro-2H-pyranyl, phenyl, ethyl, 2-hydroxy-2-methylpropyl, azetidinyl, azetidin-1-yl, morpholinyl, oxa-6-azaspiro[3.3]heptyl, 1-oxa-6-azaspiro[3.3]hept-6-yl, pyridinylamino, hexahydro-4H-furo[3,2-b]pyrrol-4-yl, (1-cyclopropylethyl)amino, (methyl)(ethyl)amino, (methyl)(isopropyl)amino, (ethyl)amino, (1-cyclobutylethyl)amino, (cyclobutylmethyl)amino, (tetrahydrofuranylmethyl)amino, (tetrahydrofuran-2-ylmethyl)amino, 8-oxa-5-azaspiro[3.5]non-5-yl, 6,7-dihydropyrazolo[1.5-a]pyrazin-5(4H)-yl, tetrahydropyranylamino, tetrahydro-2H-pyra-4-ylamino, 2-oxa-5-azabicyclo[2.2.1]hept-5-yl, oxaazabicyclo[2.2.1]heptyl, 6-oxa-2-azaspiro[3.4]oct-2-yl, cyclobutylamino, isopropylamino, (cyclopropylmethyl)amino, tetrahydrofuranylamino, tetrahydrofuran-3-ylamino, isobutylamino, propylamino, azetidinyl, azetidin-1-yl, isobutoxy, cycloproylmethoxy, pyrrolidinyl, (oxetanylmethyl)amino, (oxetan-3-ylmethyl)amino, isopropoxy, cyclobutoxy, hydrogen, and 1-phenylethyl; wherein R 4 is substituted with 0, 1, 2, or 3 groups selected from the group consisting of C 1-4 alkyl, cyano, halogen, hydroxy, and methoxy.

10. The compound according to claim 1 , wherein R 3 and R 4 along with the carbon to which they are attached may join together to form a 4- to 6-membered saturated ring system selected from the group consisting of pyrrolidinyl, pyrrolidin-2-yl, piperidinyl, tetrahydrofuranyl, and cyclopentyl, said 4- to 6-membered saturated ring system is substituted with 0, 1, or 2 moieties selected from the group consisting of C 1-6 alkyl, halogen, —SO 2 C 1-6 alkyl, C 3-6 cycloalkylcarbonyl, and —SO 2 CF 3 .

11. The compound according to claim 9 , wherein R 5 is selected from the group consisting of hydrogen, methyl, methylcarbonyl, ethyl, isopropyl, morpholinoethyl, 2-hydroxy-2-methylpropyl, 2-hydroxyethyl, 1-phenylethyl, benzyl, tetrahydro-2H-pyranylmethyl, 1-cyclopropylethyl, and tetrahydro-2H-pyranyl.

12. The compound according to claim 11 , wherein R 6 is hydrogen or oxo.

13. The compound according to claim 1 , wherein

14. The compound or a pharmaceutically acceptable salt, wherein the compound is selected from the group consisting of

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(2-methylpropyl)-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(2-methylpropyl)-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(2-methylpropyl)-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(oxetan-3-ylmethyl)-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(oxetan-3-ylmethyl)-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(oxetan-3-ylmethyl)-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[(3-methyloxetan-3-yl)methyl]-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[(3-methyloxetan-3-yl)methyl]-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[(3-methyloxetan-3-yl)methyl]-1,3-dihydro-2H-indol-2-one;

3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(R)-3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(S)-3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dimethylindolin-2-one;

(R)-3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dimethylindolin-2-one;

(S)-3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dimethylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-isobutyl-2-oxoindoline-3-carbo nitrile;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-isobutyl-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-isobutyl-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-isobutyl-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(R)-3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(S)-3-(cyclopropylmethyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

3-benzyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(R)-3-benzyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(S)-3-benzyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

6-(3-benzyl-3-methylindolin-5-yl)-9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purine;

1-(3-benzyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-1-yl)ethan-1-one;

3-benzyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dimethylindolin-2-one;

(R)-3-benzyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dimethylindolin-2-one;

(S)-3-benzyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dimethylindolin-2-one;

6-(3-benzyl-1,3-dimethylindolin-5-yl)-9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purine;

benzyl-5-(8-(difluoromethyl)-9-ethyl-9H-purin-6-yl)-3-methylindolin-2-one;

(R)-benzyl-5-(8-(difluoromethyl)-9-ethyl-9H-purin-6-yl)-3-methylindolin-2-one;

(S)-benzyl-5-(8-(difluoromethyl)-9-ethyl-9H-purin-6-yl)-3-methylindolin-2-one;

3-(cyclopropylmethyl)-5-(9-ethyl-8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(R)-3-(cyclopropylmethyl)-5-(9-ethyl-8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(S)-3-(cyclopropylmethyl)-5-(9-ethyl-8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

3-isobutyl-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(R)-3-isobutyl-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(S)-3-isobutyl-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

3-benzyl-3-methyl-5-(9-methyl-9H-purin-6-yl)indolin-2-one;

(R)-3-benzyl-3-methyl-5-(9-methyl-9H-purin-6-yl)indolin-2-one;

(S)-3-benzyl-3-methyl-5-(9-methyl-9H-purin-6-yl)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(oxetan-2-ylmethyl)indolin-2-one;

(R,R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(oxetan-2-ylmethyl)indolin-2-one;

(R,S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(oxetan-2-ylmethyl)indolin-2-one;

(S,S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(oxetan-2-ylmethyl)indolin-2-one;

(S,R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(oxetan-2-ylmethyl)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(pyrimidin-5-ylmethyl)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(tetrahydro-2H-pyran-4-yl)indolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(tetrahydro-2H-pyran-4-yl)indolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(tetrahydro-2H-pyran-4-yl)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-phenylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-phenylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-phenylindolin-2-one;

3-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(R)-3-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(S)-3-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(2-hydroxy-2-methylpropyl)-3-methylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(2-hydroxy-2-methylpropyl)-3-methylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(2-hydroxy-2-methylpropyl)-3-methylindolin-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(3-methoxy-3-methylazetidin-1-yl)-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(3-methoxy-3-methylazetidin-1-yl)-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(3-methoxy-3-methylazetidin-1-yl)-3-methyl-1,3-dihydro-2H-indol-2-one;

3-[2,6-dimethylmorpholin-4-yl]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-3-[(cis)-2,6-dimethylmorpholin-4-yl]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-3-[(cis)-2,6-dimethylmorpholin-4-yl]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

1-{5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl}-3-methylazetidine-3-carbonitrile;

(R)-1-{5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl}-3-methylazetidine-3-carbonitrile;

(S)-1-{5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl}-3-methylazetidine-3-carbonitrile;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(1-oxa-6-azaspiro[3.3]hept-6-yl)-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(1-oxa-6-azaspiro[3.3]hept-6-yl)-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(1-oxa-6-azaspiro[3.3]hept-6-yl)-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(pyridin-4-ylamino)-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(pyridin-4-ylamino)-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(pyridin-4-ylamino)-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(hexahydro-4H-furo[3,2-b]pyrrol-4-yl)-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(hexahydro-4H-furo[3,2-b]pyrrol-4-yl)-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(hexahydro-4H-furo[3,2-b]pyrrol-4-yl)-3-methyl-1,3-dihydro-2H-indol-2-one;

3-{[1-cyclopropylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

3-{[(1R)-1-cyclopropylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3 (R)-methyl-1,3-dihydro-2H-indol-2-one;

3-{[(1R)-1-cyclopropylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(S)-methyl-1,3-dihydro-2H-indol-2-one;

3-{[(1S)-1-cyclopropylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3 (R)-methyl-1,3-dihydro-2H-indol-2-one;

3-{[(1S)-1-cyclopropylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(S)-methyl-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-[(2-methoxyethyl)(methyl)amino]-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-[(2-methoxyethyl)(methyl)amino]-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-[(2-methoxyethyl)(methyl)amino]-3-methyl-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[methyl(2-methylethyl)amino]-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[methyl(1-methylethyl)amino]-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[methyl(1-methylethyl)amino]-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-[(2-methoxyethyl)amino]-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-[(2-methoxyethyl)amino]-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-[(2-methoxyethyl)amino]-3-methyl-1,3-dihydro-2H-indol-2-one;

3-{[1-cyclobutylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

3-{[(1R)-1-cyclobutylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3 (R)-methyl-1,3-dihydro-2H-indol-2-one;

3-{[(1S)-1-cyclobutylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(S)-methyl-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-{[(1-methylcyclobutyl)methyl]amino}-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-{[(1-methylcyclobutyl)methyl]amino}-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-{[(1-methylcyclobutyl)methyl]amino}-1,3-dihydro-2H-indol-2-one;

1-[({5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl}amino)methyl]cyclobutanecarbonitrile;

(R)-1-[({5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl}amino)methyl]cyclobutanecarbonitrile;

(S)-1-[({5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl}amino)methyl]cyclobutanecarbonitrile;

3-[(cyclobutylmethyl)amino]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-3-[(cyclobutylmethyl)amino]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-3-[(cyclobutylmethyl)amino]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-{[tetrahydrofuran-2-ylmethyl]amino}-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(R)-methyl-3-{[(2R)-tetrahydrofuran-2-ylmethyl]amino}-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(S)-methyl-3-{[(2R)-tetrahydrofuran-2-ylmethyl]amino}-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(8-oxa-5-azaspiro[3.5]non-5-yl)-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(8-oxa-5-azaspiro[3.5]non-5-yl)-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(8-oxa-5-azaspiro[3.5]non-5-yl)-1,3-dihydro-2H-indol-2-one;

3-(6,7-dihydropyrazolo[1,5-a]pyrazin-5 (4H)-yl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-3-(6,7-dihydropyrazolo[1,5-a]pyrazin-5 (4H)-yl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-3-(6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(tetrahydro-2H-pyran-4-ylamino)-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(tetrahydro-2H-pyran-4-ylamino)-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(tetrahydro-2H-pyran-4-ylamino)-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[2-oxa-5-azabicyclo[2.2.1]hept-5-yl]-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3 (R)-methyl-3-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(S)-methyl-3-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]-1,3-dihydro-2H-indol-2-one;

3-{[1-cyclobutylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

3-{[(1S)-1-cyclobutylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3 (R)-methyl-1,3-dihydro-2H-indol-2-one;

3-{[(1R)-1-cyclobutylethyl]amino}-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(S)-methyl-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(6-oxa-2-azaspiro[3.4]oct-2-yl)-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(6-oxa-2-azaspiro[3.4]oct-2-yl)-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(6-oxa-2-azaspiro[3.4]oct-2-yl)-1,3-dihydro-2H-indol-2-one;

3-(cyclobutylamino)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-3-(cyclobutylamino)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-3-(cyclobutylamino)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[(1-methylethyl)amino]-1,3-dihydro-2H-indol-2-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[(1-methylethyl)amino]-1,3-dihydro-2H-indol-2-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[(1-methylethyl)amino]-1,3-dihydro-2H-indol-2-one;

3-[(cyclopropylmethyl)amino]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(R)-3-[(cyclopropylmethyl)amino]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

(S)-3-[(cyclopropylmethyl)amino]-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-[tetrahydrofuran-3-ylamino]-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(R)-methyl-3-[(3 S)-tetrahydrofuran-3-ylamino]-1,3-dihydro-2H-indol-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3(S)-methyl-3-[(3 S)-tetrahydrofuran-3-ylamino]-1,3-dihydro-2H-indol-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methylindolin-2-one;

3-((5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-2-oxoindolin-3-yl)amino)-2,2-dimethylpropanenitrile;

(R)-3-((5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-2-oxoindolin-3-yl)amino)-2,2-dimethylpropanenitrile;

(S)-3-((5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-2-oxoindolin-3-yl)amino)-2,2-dimethylpropanenitrile;

3-((2,2-difluoropropyl)amino)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(R)-3-((2,2-difluoropropyl)amino)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(S)-3-((2,2-difluoropropyl)amino)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-((tetrahydrofuran-3-yl)amino)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(((S)-tetrahydrofuran-3-yl)amino)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(((S)-tetrahydrofuran-3-yl)amino)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((tetrahydrofuran-3-yl)amino)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(R)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(((S)-tetrahydrofuran-3-yl)amino)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(S)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(((S)-tetrahydrofuran-3-yl)amino)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-methoxy-3-methylazetidin-1-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-methoxy-3-methylazetidin-1-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-methoxy-3-methylazetidin-1-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

3-(cyclobutylamino)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(S)-3-(cyclobutylamino)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

(R)-3-(cyclobutylamino)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;

1-(5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methylazetidine-3-carbonitrile;

(S)-1-(5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methylazetidine-3-carbonitrile;

(R)-1-(5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methylazetidine-3-carbonitrile;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(2-fluoro-2-methylpropoxy)-3-methylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(2-fluoro-2-methylpropoxy)-3-methylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(2-fluoro-2-methylpropoxy)-3-methylindolin-2-one;

3-(cyclopropylmethoxy)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(R)-3-(cyclopropylmethoxy)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

(S)-3-(cyclopropylmethoxy)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(S)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

(R)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((2-fluoro-2-methylpropyl)amino)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;

3-(3,4-difluoropyrrolidin-1-yl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

3-(R)-((3R,4R)-3,4-difluoropyrrolidin-1-yl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

3-(S)-((3R,4R)-3,4-difluoropyrrolidin-1-yl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-fluoro-3-methylazetidin-1-yl)-3-methylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-fluoro-3-methylazetidin-1-yl)-3-methylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-fluoro-3-methylazetidin-1-yl)-3-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(isobutylamino)-3-methylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(isobutylamino)-3-methylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(isobutylamino)-3-methylindolin-2-one;

3-((2-fluoro-2-methylpropyl)amino)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)indolin-2-one;

(S)-3-((2-fluoro-2-methylpropyl)amino)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)indolin-2-one;

(R)-3-((2-fluoro-2-methylpropyl)amino)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)indolin-2-one;

3-((2,2-difluoropropyl)amino)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)indolin-2-one;

(R)-3-((2,2-difluoropropyl)amino)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)indolin-2-one;

(S)-3-((2,2-difluoropropyl)amino)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(((3-fluorooxetan-3-yl)methyl)amino)-3-methylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(((3-fluorooxetan-3-yl)methyl)amino)-3-methylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(((3-fluorooxetan-3-yl)methyl)amino)-3-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-isopropoxy-3-methylindolin-2-one;

3-cyclobutoxy-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methylindolin-2-one;

3-(cyclopropylmethoxy)-3-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-((tetrahydrofuran-3-yl)amino)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(R)-methyl-3-(((R)-tetrahydrofuran-3-yl)amino)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(S)-methyl-3-(((R)-tetrahydrofuran-3-yl)amino)indolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-methoxy-3-methylazetidin-1-yl)-2-oxoindoline-3-carbonitrile;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-methoxyazetidin-1-yl)-3-methylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-methoxyazetidin-1-yl)-3-(3-methoxyazetidin-methylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-methoxyazetidin-1-yl)-3-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-hydroxy-3-methyl azetidin-1-yl)-3-methylindolin-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-hydroxy-3-methylazetidin-1-yl)-3-methylindolin-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(3-hydroxy-3-methylazetidin-1-yl)-3-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-((3-methoxycyclobutyl)amino)-3-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(((1R,3R)-3-methoxycyclobutyl)amino)-3 (R)-methylindolin-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(((1R,3R)-3-methoxycyclobutyl)amino)-3(S)-methylindolin-2-one;

1′-(cyclopropylcarbonyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]spiro[indole-3,2′-pyrrolidin]-2(1H)-one;

(R)-1′-(cyclopropylcarbonyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]spiro[indole-3,2′-pyrrolidin]-2(1H)-one;

(S)-1′-(cyclopropylcarbonyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]spiro[indole-3,2′-pyrrolidin]-2(1H)-one;

1′-(cyclopropylcarbonyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1-methylspiro[indole-3,2′-pyrrolidin]-2(1H)-one;

(R)-1′-(cyclopropylcarbonyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1-methylspiro[indole-3,2′-pyrrolidin]-2(1H)-one;

(S)-1′-(cyclopropylcarbonyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1-methylspiro[indole-3,2′-pyrrolidin]-2(1H)-one;

1′-(cyclopropanecarbonyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,3′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,3′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,3′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-1-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-1-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-1-methyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-1-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-1-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-1-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-isopropylspiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-isopropylspiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-isopropylspiro[indoline-3,2′-pyrrolidin]-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-isopropylspiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-isopropylspiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-isopropylspiro[indoline-3,2′-pyrrolidin]-2-one;

1′-isopropyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-isopropyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-isopropyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-5-(8-(difluoromethyl)-9-ethyl-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-5-(8-(difluoromethyl)-9-ethyl-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-5-(8-(difluoromethyl)-9-ethyl-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-(2-morpholinoethyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-(2-morpholinoethyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-(2-morpholinoethyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-1-(2-hydroxy-2-methylpropyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-1-(2-hydroxy-2-methylpropyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-1-(2-hydroxy-2-methylpropyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-1-(2-hydroxyethyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-(cyclopropanecarbonyl)-1-(2-hydroxyethyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-(cyclopropanecarbonyl)-1-(2-hydroxyethyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-(methylsulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-(methylsulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-(methylsulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-((trifluoromethyl)sulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-((trifluoromethyl)sulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-((trifluoromethyl)sulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-methyl-1′-(methylsulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-methyl-1′-(methyl sulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1-methyl-1′-(methyl sulfonyl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-(cyclopropanecarbonyl)-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,4′-piperidin]-2-one;

1′-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-ethyl-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

1′-ethyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-1′-ethyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-1′-ethyl-5-(9-methyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

5′-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-4,5-dihydro-3H-spiro[furan-2,3′-indolin]-2′-one;

(R)-5′-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-4,5-dihydro-3H-spiro[furan-2,3′-indolin]-2′-one;

(S)-5′-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-4,5-dihydro-3H-spiro[furan-2,3′-indolin]-2′-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[indoline-3,2′-pyrrolidin]-2-one;

5′-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)spiro[cyclopentane-1,3′-indolin]-2′-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-isopropylspiro[indoline-3,3′-pyrrolidin]-2-one;

(R)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-isopropylspiro[indoline-3,3′-pyrrolidin]-2-one;

(S)-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-1′-isopropylspiro[indoline-3,3′-pyrrolidin]-2-one;

4-benzyl-6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,4-dihydro-2H-3,1-benzoxazin-2-one;

(R)-4-benzyl-6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,4-dihydro-2H-3,1-benzoxazin-2-one;

(S)-4-benzyl-6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,4-dihydro-2H-3,1-benzoxazin-2-one;

6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-4-methyl-4-(2-methylpropyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one;

(R)-6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-4-methyl-4-(2-methylpropyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one;

(S)-6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-4-methyl-4-(2-methylpropyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one;

9-ethyl-6-[3-methyl-3-(2-methylpropyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]-8-(2-methylpyrimidin-5-yl)-9H-purine;

(R)-9-ethyl-6-[3-methyl-3-(2-methylpropyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]-8-(2-methylpyrimidin-5-yl)-9H-purine;

(S)-9-ethyl-6-[3-methyl-3-(2-methylpropyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]-8-(2-methylpyrimidin-5-yl)-9H-purine;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(2-methylpropyl)-2,3-dihydro-1H-isoindol-1-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(2-methylpropyl)-2,3-dihydro-1H-isoindol-1-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-3-(2-methylpropyl)-2,3-dihydro-1H-isoindol-1-one;

3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-2,3-dihydro-1H-isoindol-1-one;

(R)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-2,3-dihydro-1H-isoindol-1-one;

(S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-2,3-dihydro-1H-isoindol-1-one;

3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2,3-dihydro-1H-isoindol-1-one;

(R)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2,3-dihydro-1H-isoindol-1-one;

(S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-2,3-dihydro-1H-isoindol-1-one;

3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-2,3-dimethyl-2,3-dihydro-1H-isoindol-1-one;

(R)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-2,3-dimethyl-2,3-dihydro-1H-isoindol-1-one;

(S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-2,3-dimethyl-2,3-dihydro-1H-isoindol-1-one;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-2-methyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide;

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)isoindolin-1-one;

6-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-4-methyl-4-phenyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(1-phenylethyl)-1,3-benzoxazol-2(3H)-one;

(R)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(1-phenylethyl)-1,3-benzoxazol-2(3H)-one;

(S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(1-phenylethyl)-1,3-benzoxazol-2(3H)-one;

3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,3-benzoxazol-2(3H)-one;

5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-(tetrahydro-2H-pyran-4-ylmethyl)-1,3-benzoxazol-2(3H)-one;

3-(1-cyclopropylethyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,3-benzoxazol-2(3H)-one;

(R)-3-(1-cyclopropylethyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,3-benzoxazol-2(3H)-one;

(S)-3-(1-cyclopropylethyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,3-benzoxazol-2(3H)-one;

1-(1-cyclopropylethyl)-6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,3-dihydro-2H-benzimidazol-2-one;

(R)-1-(1-cyclopropylethyl)-6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,3-dihydro-2H-benzimidazol-2-one;

(S)-1-(1-cyclopropylethyl)-6-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-1,3-dihydro-2H-benzimidazol-2-one; and

5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-(tetrahydro-2H-pyran-4-yl)benzo[d]oxazol-2(3H)-one.

15. The pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt or stereoisomer thereof and a pharmaceutically acceptable carrier.

16. The pharmaceutical composition according to claim 15 , further comprising one or more other therapeutic agents.

17. A method for the treatment of a PI3K-delta-mediated disease comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt or a stereoisomer thereof.

18. A method of treating a condition in a mammal that can be ameliorated by the selective inhibition of PI3K-delta which condition is selected from the group consisting of arthritis, asthma and obstructive airways diseases, autoimmune diseases or disorders, and cancer comprising administering to the mammal in need of such treatment, a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt or a stereoisomer thereof.

19. The method according to claim 18 , wherein said condition is arthritis.

20. The method according to claim 19 , wherein said condition is selected from the group consisting of rheumatoid arthritis, juvenile arthritis, and psoriatic arthritis.

21. The method according to claim 18 , wherein said condition is asthma or obstructive airways diseases.

22. The method according to claim 21 , wherein said condition is selected from the group consisting of chronic asthma, late asthma, airway hyper-responsiveness, bronchitis, bronchial asthma, allergic asthma, intrinsic asthma, extrinsic asthma, dust asthma, recurrent airway obstruction, and chronic obstruction pulmonary disease (COPD), and emphysema.

23. A method of treating asthma in a mammal in need thereof, comprising administering a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.

24. A method of treating arthritis in a mammal in need thereof, comprising administering a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.

25. A method of treating cancer in a mammal in need thereof, comprising administering a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.