Radiation mitigator and method of use thereof
Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.
1. A method for treating or preventing radiation-induced tissue injury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound represented by formula I
or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—, thereby treating or preventing radiation-induced tissue injury in the subject.
2. The method of claim 1 , wherein Z is —O—.
3. The method of claim 1 , wherein Z is —N(H)—.
4. The method of claim 1 , wherein the compound is administered prior to exposure of the subject to radiation.
5. The method of claim 1 , wherein the compound is administered after exposure of the subject to radiation.
6. The method of claim 1 , wherein the radiation-induced tissue injury is acute radiation-induced tissue injury.
7. The method of claim 1 , wherein the radiation-induced tissue injury is chronic radiation-induced tissue injury.
8. The method of claim 1 , wherein the tissue comprises gastrointestinal tissue.
9. The method of claim 1 , wherein the tissue comprises hematopoietic tissue.
10. The method of claim 1 , wherein the tissue comprises neural tissue.
11. The method of claim 1 , wherein the compound is administered orally.
12. The method of claim 1 , wherein the compound is administered parenterally.
13. The method of claim 1 , wherein the subject is a mammal.
14. The method of claim 1 , wherein the subject is a human.
15. The method of claim 1 , wherein the radiation-induced tissue injury is prevented.
16. The method of claim 1 , wherein the radiation-induced tissue injury is treated.