IP Library Granted Patent US 10,617,134
Granted Patent B2
US 10,617,134 · App. 16/093,923 · Granted Apr 14, 2020

Methods for improving agricultural production of fowl by administration of microbial compositions or purified strains thereof

Inventors: Mallory Embree (San Diego, CA); Grant Gogul (Cardiff, CA); Cameron Martino (San Diego, CA); Norm Pitt (San Diego, CA)
Assignee: Ascus Biosciences, Inc.
A23K10/18A23K40/30A23K50/75A61K9/0053A61K35/742C12N1/20C12R1/01A61K2035/115
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Quick Facts
Patent No.
US 10,617,134
App. No.
16/093,923
Granted
Apr 14, 2020
Kind
B2
Abstract

The disclosure relates to isolated microorganisms-including novel strains of the microorganisms-microbial consortia, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial consortia, and compositions comprising the same, in methods for modulating the production of poultry, disease resistance, and egg yield. In particular aspects, the disclosure provides methods of increasing feed efficiency, and methods of preventing colonization of pathogenic microbes.

Claims (24)

1. A method for decreasing incidence of mortality in a chicken, the method comprising:

(a) administering to the chicken an effective amount of a chicken feed composition comprising:

(i) chicken feed, and

(ii) a Bacillus sp. comprising the 16S nucleic acid sequence of SEQ ID NO: 13,

wherein the chicken administered the effective amount of the chicken feed composition exhibits a decrease in the incidence of mortality, as compared to a chicken not having been administered the composition.

2. The method of claim 1 , wherein the administering of the chicken feed composition is an oral administration.

3. The method of claim 1 , wherein the Bacillus sp. is in spore form.

4. The method of claim 1 , wherein the Bacillus sp. further comprises an exogenous starch.

5. The method of claim 1 , wherein the chicken feed composition is administered to the chicken at least once a day.

6. The method of claim 5 , wherein each administration of the chicken feed composition comprises at least 10 3 spores of the Bacillus sp.

7. The method of claim 1 , wherein the chicken is a broiler.

8. The method of claim 1 , wherein the chicken feed composition is dried.

9. The method of claim 8 , wherein the Bacillus sp. is freeze dried.

10. The method of claim 8 , wherein the chicken feed composition has a moisture content of less than 10%.

11. The method of claim 1 , wherein the chicken feed is in pellet form, capsule form, granulated, powdered, mash, liquid, or semi-liquid.

12. The method of claim 1 , wherein the chicken feed composition comprises premix, forage, fodder, beans, grains, oil, haylage, silage, syrup, fatty acid, sugar alcohol, and/or oyster shell; or mixtures thereof.

13. The method of claim 12 , wherein the chicken feed composition comprises the Bacillus sp. within or on pelleted feed.

14. The method of claim 1 , wherein the incidence of mortality decreases by at least 1%.

15. The method of claim 14 , wherein the incidence of mortality decreases by at least 5%.

16. The method of claim 1 , wherein the administration of the chicken feed composition shifts the gut microbiome of the chicken.

17. The method of claim 16 , wherein the gut microbiome shift is a decrease in the relative abundance of one or more microbes that were present in the gut prior to the administration of the chicken feed composition.

18. The method of claim 16 , wherein the gut microbiome shift is an increase in the relative abundance of one or more microbes that were present in the gut prior to the administration of the chicken feed composition.

19. The method of claim 18 , wherein the gut microbiome shift is an increase in the relative abundance of obligate anaerobes.

20. The method of claim 18 , wherein the gut microbiome shift is an increase in the relative abundance of lactic acid-producing microbes.

Assignments (3)
SECURITY INTEREST Recorded Jul 30, 2025
From: NATIVE MICROBIALS, INC.
To: WESTERN ALLIANCE BANK
Reel/Frame 072324/0001 →
CHANGE OF NAME Recorded Sep 9, 2020
From: ASCUS BIOSCIENCES, INC.
To: NATIVE MICROBIALS, INC.
Reel/Frame 053732/0496 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2019
From: EMBREE, MALLORY; GOGUL, GRANT; MARTINO, CAMERON; PITT, NORM
To: ASCUS BIOSCIENCES, INC.
Reel/Frame 048137/0014 →
Continuity (4)
Provisional Application 62323305 · Apr 15, 2016
Provisional Application 62335559 · May 12, 2016
Provisional Application 62425480 · Nov 22, 2016
Related Publication 20190269742A1 · Sep 5, 2019