IP Library Granted Patent US 11,597,706
Granted Patent B2
US 11,597,706 · App. 16/094,491 · Granted Mar 7, 2023

Compounds and compositions for treating conditions associated with NLRP activity

Inventors: Gary Glick (Ann Arbor, MI); Shomir Ghosh (Brookline, MA); William R. Roush (Jupiter, FL)
Assignee: Novartis AG
C07D263/46C07C317/22C07D213/34C07D213/71C07D277/36C07D295/096C07D307/64C07D311/54C07D333/34C07D405/12C07D417/12C07C2603/10
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Quick Facts
Patent No.
US 11,597,706
App. No.
16/094,491
Granted
Mar 7, 2023
Kind
B2
Abstract

In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured: Formulae (I) and (II), wherein the variables shown in Formulae (I) and (II) can be as defined anywhere herein.

Claims (65)

1. A compound selected from the group consisting of compounds in the Table below:

Com-

pound

Structure

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

131

135

136

137

138

142

143

144

145

146

147

148

149

151

153

154

155

157

158

159

160

161

163

164

166

167

168

169

170

and

171

or pharmaceutically acceptable salts thereof.

2. A pharmaceutical composition comprising a compound or salt as claimed in claim 1 and one or more pharmaceutically acceptable excipients.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 5, 2021
From: NOVARTIS INFLAMMASOME RESEARCH, INC.
To: NOVARTIS AG
Reel/Frame 055166/0306 →
EMPLOYMENT AGREEMENT Recorded Aug 7, 2019
From: GLICK, GARY D; GHOSH, SHOMIR; ROUSH, WILLIAM R
To: IFM THERAPEUTICS, INC.
Reel/Frame 049987/0946 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2019
From: IFM THERAPEUTICS, INC.
To: IFM THERAPEUTICS, LLC
Reel/Frame 049700/0073 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2019
From: IFM THERAPEUTICS, LLC
To: IFM INFLAMMATION, INC.
Reel/Frame 049700/0208 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2019
From: GLICK, GARY; GHOSH, SHOMIR; ROUSH, WILLIAM R.
To: IFM TRE, INC.
Reel/Frame 047988/0095 →
Continuity (3)
Provisional Application 62324071 · Apr 18, 2016
Provisional Application 62324081 · Apr 18, 2016
Related Publication 20190119203A1 · Apr 25, 2019