Anti-infective 2-aminothiophenes
2-Aminothiophene derivatives, uses of the same, and methods of making the same, are described.
1. A compound of Formula III:
wherein R 5 is NEt, R 6 is COPhF 5 , and R 7 is C 1 -C 8 alkyl, C 1 -C 8 alkoxy, or C 1 -C 8 alkylamino.
2. A compound of Formula 506:
3. A compound of Formula 507:
4. A compound of Formula 508:
5. A compound of Formula 509:
6. A compound of Formula 510:
7. A compound of Formula 511:
8. A compound of Formula 512:
9. A compound of Formula 513:
10. A compound of Formula 514:
11. A compound of Formula 515:
12. A compound of Formula V:
wherein:
R 1 is H, or substituted or unsubstituted C 1 -C 8 acyl, C 1 -C 8 alkyl, C 1 -C 8 aminoalkyl, C 1 -C 8 alkenyl, or Ph; and
R 2 is a substituted or substituted tetrazole, oxadiazole, thiadiazole, thiadiazole ketone, oxadiazolethione, amide, acylurea, or oxadiazole ketone;
and salts, stereoisomers, racemates, hydrates, solvates, prodrugs, and polymorphs thereof.