Method for aromatic fluorination
Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO 2 F 2 to a reaction mixture; reacting the SO 2 F 2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where A is an aryl or heteroaryl; providing SO 2 F 2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO 2 F 2 , the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.
1. A fluorination method comprising:
providing an aryl fluorosulfonate having the following structure to a reaction mixture:
wherein Ar is aryl or heteroaryl;
providing a fluorinating reagent to the reaction mixture; and
reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species having the following structure:
2. The fluorination method of claim 1 , wherein the solvent is selected from the group consisting of polar aprotic solvents, alkoxy ether solvents, nitrile solvents, and aromatic solvents.
3. The fluorination method of claim 1 , wherein the fluorinating reagent is selected from the group consisting of sodium fluoride, potassium fluoride, cesium fluoride, lithium fluoride, tetrabutylammonium fluoride, and tetramethylammonium fluoride.
4. A method according to claim 1 , further comprising providing a solvent to the reaction mixture.